| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Ugly Truth | $17,394 | - | 6 | - | $2,899 | $30,002 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Inglourious Basterds | $14,433 | -20.1% | 6 | - | $2,405 | $131,945 | 4 | United International Pictures | false | false |
| 3 | 2 | Ice Age: Dawn of the Dinosaurs | $9,742 | <0.1% | 9 | - | $1,082 | $373,736 | 11 | 20th Century Fox International | false | false |
| 4 | 3 | The Taking of Pelham 123 | $4,554 | -28.1% | 5 | - | $910 | $27,517 | 3 | Sony Pictures Releasing | false | false |
| 5 | 6 | G-Force | $3,945 | -15.8% | 5 | - | $789 | $22,695 | 3 | Walt Disney Pictures | false | false |
| 6 | 5 | The Proposal | $2,188 | -53.6% | 6 | - | $364 | $102,542 | 8 | Walt Disney Pictures | false | false |
| 7 | 7 | Harry Potter and the Half-Blood Prince | $1,734 | -35.5% | 8 | - | $216 | $184,981 | 9 | Warner Bros. | false | false |
| 8 | 4 | Two Lovers | $1,501 | -70.7% | 3 | - | $500 | $10,570 | 3 | N/A | false | false |
| 9 | 8 | Public Enemies | $1,279 | -43.6% | 5 | - | $255 | $74,986 | 11 | United International Pictures | false | false |
| 10 | 9 | The Hangover | $716 | -54.5% | 5 | - | $143 | $140,743 | 13 | Warner Bros. | false | false |
| 11 | 19 | Night at the Museum: Battle of the Smithsonian | $673 | +485.2% | 6 | - | $112 | $61,532 | 17 | 20th Century Fox International | false | false |
| 12 | - | Superhero Movie | $603 | - | 1 | - | $603 | $2,427 | 2 | N/A | false | false |
| 13 | 10 | Knowing | $559 | -46.4% | 4 | - | $139 | $26,112 | 7 | N/A | false | false |
| 14 | 13 | Coraline | $448 | -11.8% | 4 | - | $112 | $34,277 | 15 | United International Pictures | false | false |
| 15 | 11 | Brüno | $216 | -74.6% | 6 | +1 | $36 | $64,488 | 10 | N/A | false | false |
| 16 | 15 | Hannah Montana: The Movie | $215 | -13.7% | 5 | - | $43 | $32,471 | 14 | Walt Disney Pictures | false | false |
| 17 | 17 | Ghosts of Girlfriends Past | $79 | -65.5% | 5 | - | $15 | $58,720 | 14 | Warner Bros. | false | false |
| 18 | 14 | Transformers: Revenge of the Fallen | $69 | -78.8% | 8 | - | $8 | $82,148 | 12 | United International Pictures | false | false |
| 19 | 16 | Hotel for Dogs | $49 | -79.1% | 6 | - | $8 | $33,607 | 21 | United International Pictures | false | false |
| 20 | 18 | Terminator Salvation | $43 | -80.5% | 2 | -2 | $21 | $91,632 | 15 | Sony Pictures Releasing | false | false |
| 21 | 21 | Taken | $23 | - | 2 | - | $11 | $5,004 | 13 | N/A | false | false |
