| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Final Destination | $61,181 | - | 6 | - | $10,196 | $69,285 | 1 | - | true | false |
| 3 | - | High Security Vacation | $21,569 | - | 4 | - | $5,392 | $21,569 | 1 | ACME | true | false |
| 4 | 2 | Inglourious Basterds | $21,387 | -39.4% | 6 | - | $3,564 | $86,551 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | - | Vortex | $9,289 | - | 3 | - | $3,096 | $9,289 | 13 | N/A | false | false |
| 2 | 1 | Up | $33,908 | -38.8% | 12 | - | $2,825 | $325,214 | 3 | Universal Pictures International (UPI) | false | false |
| 8 | 5 | My Sister's Keeper | $6,054 | -10.9% | 4 | - | $1,513 | $94,305 | 5 | - | false | false |
| 10 | 8 | Diary of a Nymphomaniac | $2,574 | -0.7% | 2 | - | $1,287 | $31,406 | 5 | ACME | false | false |
| 6 | 4 | District 9 | $8,080 | -40.9% | 7 | - | $1,154 | $85,133 | 4 | Sony Pictures Releasing | false | false |
| 7 | 3 | Ice Age: Dawn of the Dinosaurs | $7,074 | -49.5% | 7 | -3 | $1,010 | $1,358,217 | 10 | Universal Pictures International (UPI) | false | false |
| 11 | 7 | G.I. Joe: The Rise of Cobra | $2,277 | -47.7% | 4 | - | $569 | $50,105 | 4 | Universal Pictures International (UPI) | false | false |
| 9 | 6 | Harry Potter and the Half-Blood Prince | $3,186 | -37.3% | 7 | +2 | $455 | $308,537 | 7 | Garsu Pasaulio Irasai | false | false |
| 12 | - | Year One | $696 | - | 2 | - | $348 | $74,356 | 1 | Sony Pictures Releasing | true | false |
| 15 | 13 | Let the Right One In | $302 | -58.9% | 1 | - | $302 | $797 | 3 | Universal Pictures International (UPI) | false | false |
| 13 | - | The Hangover | $546 | - | 2 | - | $273 | $293,731 | 13 | - | false | false |
| 17 | 15 | Lorna's Silence | $228 | -66.7% | 1 | - | $228 | $2,081 | 2 | N/A | false | false |
| 14 | 11 | Brüno | $418 | -65.5% | 2 | -1 | $209 | $149,662 | 7 | ACME | false | false |
| 16 | 14 | Gomorrah | $245 | -66.2% | 2 | - | $122 | $25,348 | 8 | Universal Pictures International (UPI) | false | false |
| 20 | 10 | The Taking of Pelham 123 | $113 | -93.3% | 1 | -3 | $113 | $70,389 | 6 | Sony Pictures Releasing | false | false |
| 18 | 19 | Bolt | $221 | +118.8% | 2 | - | $110 | $335,275 | 28 | Universal Pictures International (UPI) | false | false |
| 19 | - | Public Enemies | $130 | - | 2 | - | $65 | $89,847 | 9 | Universal Pictures International (UPI) | false | false |
