| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | He's Just Not That Into You | $1,999,336 | - | 336 | - | $5,950 | $2,211,124 | 1 | TriPictures | true | false |
| 2 | - | Up | $1,143,801 | - | 457 | - | $2,502 | $32,126,814 | 6 | Walt Disney Pictures | false | false |
| 3 | - | Gamer | $922,360 | - | 302 | - | $3,054 | $922,360 | 1 | N/A | true | false |
| 4 | - | Year One | $747,769 | - | 222 | - | $3,368 | $2,552,267 | 2 | Sony Pictures Releasing | false | false |
| 5 | - | The Hangover | $734,002 | - | 317 | - | $2,315 | $7,014,030 | 4 | Warner Bros. | false | false |
| 6 | - | Public Enemies | $676,005 | - | 368 | - | $1,836 | $9,150,521 | 4 | United International Pictures | false | false |
| 7 | - | Case 39 | $674,123 | - | 221 | - | $3,050 | $2,294,068 | 2 | Paramount Pictures International | false | false |
| 8 | - | Map of the Sounds of Tokyo | $454,841 | - | 170 | - | $2,675 | $1,663,129 | 2 | Alta Films | false | false |
| 9 | - | Guts | $408,041 | - | 164 | - | $2,488 | $408,041 | 1 | Sony Pictures Releasing | true | false |
| 10 | - | Funny People | $362,296 | - | 182 | - | $1,990 | $362,296 | 1 | United International Pictures | true | false |
| 11 | - | Spread | $343,433 | - | 203 | - | $1,691 | $1,420,298 | 2 | - | false | false |
| 12 | - | Aliens in the Attic | $308,824 | - | 301 | - | $1,025 | $4,211,575 | 4 | 20th Century Fox International | false | false |
| 13 | - | Shorts | $249,761 | - | 165 | - | $1,513 | $865,240 | 2 | Warner Bros. | false | false |
| 14 | - | Frozen River | $154,193 | - | 36 | - | $4,283 | $154,193 | 1 | Sagrera TV | true | false |
| 15 | - | The Girl with the Dragon Tattoo | $119,803 | - | 91 | - | $1,316 | $12,458,324 | 15 | Vértigo Films | false | false |
| 16 | - | Ice Age: Dawn of the Dinosaurs | $86,199 | - | 118 | - | $730 | $30,732,173 | 10 | 20th Century Fox International | false | false |
| 17 | - | G.I. Joe: The Rise of Cobra | $76,930 | - | 131 | - | $587 | $6,427,226 | 5 | Paramount Pictures International | false | false |
| 18 | - | A French Gigolo | $73,920 | - | 50 | - | $1,478 | $73,920 | 1 | Vértigo Films | true | false |
| 19 | - | The Taking of Pelham 123 | $67,654 | - | 88 | - | $768 | $8,783,182 | 7 | Sony Pictures Releasing | false | false |
| 20 | - | Antichrist | $60,011 | - | 73 | - | $822 | $610,167 | 3 | Golem Distribución | false | false |
| 21 | - | Motherhood | $58,168 | - | 104 | - | $559 | $297,582 | 2 | DeAPlaneta | false | false |
| 22 | - | Ong Bak 2 | $51,451 | - | 111 | - | $463 | $1,079,676 | 3 | - | false | false |
| 23 | - | Harry Potter and the Half-Blood Prince | $38,634 | - | 77 | - | $501 | $19,947,062 | 8 | Warner Bros. | false | false |
| 24 | - | The Haunting in Connecticut | $35,777 | - | 70 | - | $511 | $2,384,040 | 5 | DeAPlaneta | false | false |
| 25 | - | Land of the Lost | $23,368 | - | 44 | - | $531 | $472,701 | 3 | United International Pictures | false | false |
| 26 | - | My Life in Ruins | $20,335 | - | 55 | - | $369 | $1,778,807 | 5 | Manga Entertainment | false | false |
| 27 | - | Ex | $16,788 | - | 18 | - | $932 | $1,017,239 | 7 | Notro Films | false | false |
| 28 | - | Departures | $15,684 | - | 11 | - | $1,425 | $559,568 | 10 | Golem Distribución | false | false |
| 29 | - | Drag Me to Hell | $12,451 | - | 37 | - | $336 | $3,641,653 | 6 | United International Pictures | false | false |
| 30 | - | Small Country | $11,367 | - | 5 | - | $2,273 | $348,105 | 7 | Alta Films | false | false |
| 31 | - | The First Day of the Rest of Your Life | $11,005 | - | 7 | - | $1,572 | $776,972 | 12 | N/A | false | false |
| 32 | - | Mid-August Lunch | $10,266 | - | 7 | - | $1,466 | $1,166,889 | 16 | Alta Films | false | false |
| 33 | - | The Year My Parents Went on Vacation | $6,678 | - | 8 | - | $834 | $123,551 | 4 | Vértigo Films | false | false |
| 34 | - | The Life Before Her Eyes | $5,883 | - | 16 | - | $367 | $126,239 | 3 | Manga Entertainment | false | false |
| 35 | - | Satin Rouge 2009 Re-release | $5,448 | - | 4 | - | $1,362 | $98,188 | 6 | Karma Films | false | false |
| 36 | - | V.O.S. | $4,779 | - | 6 | - | $796 | $257,455 | 9 | Alta Films | false | false |
| 37 | - | Friend Zone | $4,452 | - | 9 | - | $494 | $2,859,374 | 10 | Manga Entertainment | false | false |
| 38 | - | Three Days with the Family | $3,562 | - | 6 | - | $593 | $362,244 | 11 | N/A | false | false |
| 39 | - | A Boyfriend for My Wife | $2,997 | - | 3 | - | $999 | $506,010 | 9 | N/A | false | false |
| 40 | - | Tear This Heart Out | $2,697 | - | 5 | - | $539 | $484,292 | 7 | Wanda Visión S.A. | false | false |
| 41 | - | Owl and the Sparrow | $2,538 | - | 5 | - | $507 | $105,636 | 7 | N/A | false | false |
| 42 | - | Don't Look Down | $1,987 | - | 5 | - | $397 | $111,077 | 8 | Karma Films | false | false |
| 43 | - | Brüno | $1,954 | - | 2 | - | $977 | $2,537,920 | 9 | Sony Pictures Releasing | false | false |
| 44 | - | LOL (Laughing Out Loud) | $1,922 | - | 1 | - | $1,922 | $824,504 | 11 | Alta Films | false | false |
| 45 | - | Beyond a Reasonable Doubt | $1,903 | - | 5 | - | $380 | $2,257,921 | 9 | DeAPlaneta | false | false |
| 46 | - | Gran Torino | $1,872 | - | 4 | - | $468 | $18,323,921 | 27 | Warner Bros. | false | false |
| 47 | - | Lilly the Witch: The Dragon and the Magic Book | $1,789 | - | 5 | - | $357 | $3,405,041 | 13 | Walt Disney Pictures | false | false |
| 48 | - | Pandora's Box | $1,787 | - | 4 | - | $446 | $327,070 | 13 | Karma Films | false | false |
| 49 | - | Angels & Demons | $1,289 | - | 7 | - | $184 | $21,936,475 | 17 | Sony Pictures Releasing | false | false |
| 50 | - | Sex Drive | $1,016 | - | 1 | - | $1,016 | $703,313 | 6 | Paramount Pictures International | false | false |
| 51 | - | Lokas 2009 Re-release | $997 | - | 7 | - | $142 | $10,037 | 2 | N/A | false | false |
| 52 | - | Glory to the Filmmaker! | $725 | - | 3 | - | $241 | $6,082 | 2 | N/A | false | false |
| 53 | - | Transformers: Revenge of the Fallen | $516 | - | 5 | - | $103 | $8,698,257 | 11 | Paramount Pictures International | false | false |
| 54 | - | Ashes of Time | $505 | - | 3 | - | $168 | $57,060 | 6 | Vértigo Films | false | false |
| 55 | - | Labor Pains | $471 | - | 3 | - | $157 | $287,260 | 6 | DeAPlaneta | false | false |
| 56 | - | How to Lose Friends & Alienate People | $414 | - | 4 | - | $103 | $975,607 | 7 | Warner Bros. | false | false |
| 57 | - | The Visitor | $387 | - | 1 | - | $387 | $1,512,539 | 26 | Karma Films | false | false |
| 58 | - | Paranoid Park | $270 | - | 1 | - | $270 | $63,314 | 9 | N/A | false | false |
| 59 | - | The Last House on the Left | $226 | - | 2 | - | $113 | $2,886,802 | 10 | United International Pictures | false | false |
| 60 | - | Seraphine | $149 | - | 1 | - | $149 | $564,481 | 18 | Golem Distribución | false | false |
| 61 | - | My Führer 2009 Re-release | $128 | - | 1 | - | $128 | $84,287 | 5 | N/A | false | false |
| 62 | - | Coco Before Chanel | $34 | - | 1 | - | $34 | $2,448,911 | 14 | Warner Bros. | false | false |
