| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | The Final Destination | $28,335,000 | $27,408,309 | -$926,691 | -3.3% | 3,121 | $28,335,000 | $27,408,309 | 1 | Warner Bros. | - |
| 2 | 2 | - | Inglourious Basterds | $20,041,000 | $19,303,653 | -$737,347 | -3.7% | 3,165 | $73,760,000 | $73,022,841 | 2 | The Weinstein Company | - |
| 3 | 3 | - | Halloween II | $17,405,000 | $16,349,565 | -$1,055,435 | -6.1% | 3,025 | $17,405,000 | $16,349,565 | 1 | Dimension Films | - |
| 4 | 4 | - | District 9 | $10,700,000 | $10,270,435 | -$429,565 | -4% | 3,180 | $90,813,000 | $90,383,712 | 3 | TriStar Pictures | - |
| 5 | 5 | - | G.I. Joe: The Rise of Cobra | $8,000,000 | $7,715,572 | -$284,428 | -3.6% | 3,467 | $132,436,000 | $132,151,954 | 4 | Paramount Pictures | - |
| 6 | 6 | - | Julie & Julia | $7,400,000 | $7,035,675 | -$364,325 | -4.9% | 2,503 | $70,992,000 | $70,628,063 | 4 | Sony Pictures Releasing | - |
| 7 | 7 | - | The Time Traveler's Wife | $6,745,000 | $6,452,270 | -$292,730 | -4.3% | 2,961 | $48,193,000 | $47,900,418 | 3 | Warner Bros. | - |
| 8 | 8 | - | Shorts | $4,870,000 | $4,511,345 | -$358,655 | -7.4% | 3,105 | $13,565,000 | $13,206,697 | 2 | Warner Bros. | - |
| 9 | 9 | - | Taking Woodstock | $3,749,000 | $3,457,760 | -$291,240 | -7.8% | 1,393 | $3,769,000 | $3,478,335 | 1 | Focus Features | - |
| 10 | 10 | - | G-Force | $2,845,000 | $2,824,808 | -$20,192 | -0.7% | 1,926 | $111,801,000 | $111,780,350 | 6 | Walt Disney Studios Motion Pictures | - |
| 11 | 11 | - | Harry Potter and the Half-Blood Prince | $2,615,000 | $2,466,423 | -$148,577 | -5.7% | 1,508 | $294,407,000 | $294,258,075 | 7 | Warner Bros. | - |
| 12 | 12 | - | 500 Days of Summer | $2,075,000 | $2,008,956 | -$66,044 | -3.2% | 909 | $25,270,000 | $25,203,886 | 7 | Fox Searchlight Pictures | - |
| 13 | 13 | - | Ponyo | $1,958,000 | $1,887,921 | -$70,079 | -3.6% | 880 | $11,103,000 | $11,033,256 | 3 | Walt Disney Studios Motion Pictures | - |
| 14 | 14 | - | The Ugly Truth | $1,700,000 | $1,587,710 | -$112,290 | -6.6% | 1,252 | $85,860,000 | $85,747,932 | 6 | Sony Pictures Releasing | - |
| 15 | 15 | - | Post Grad | $1,531,000 | $1,467,947 | -$63,053 | -4.1% | 1,959 | $5,371,000 | $5,307,922 | 2 | Twentieth Century Fox | - |
| 16 | 16 | - | The Hangover | $1,450,000 | $1,340,141 | -$109,859 | -7.6% | 801 | $270,348,000 | $270,237,753 | 13 | Warner Bros. | - |
| 17 | 17 | - | The Goods: Live Hard, Sell Hard | $1,215,000 | $1,188,109 | -$26,891 | -2.2% | 1,426 | $13,845,000 | $13,817,928 | 3 | Paramount Vantage | - |
| 18 | 18 | - | The Proposal | $650,000 | $664,375 | +$14,375 | +2.2% | 520 | $160,140,000 | $160,154,402 | 11 | Walt Disney Studios Motion Pictures | - |
| 19 | 19 | - | Up | $605,000 | $649,188 | +$44,188 | +7.3% | 392 | $289,596,000 | $289,639,811 | 14 | Walt Disney Studios Motion Pictures | - |
| 20 | 20 | - | Transformers: Revenge of the Fallen | $575,000 | $575,531 | +$531 | <0.1% | 622 | $399,415,000 | $399,416,040 | 10 | DreamWorks | - |
| 21 | 21 | - | Ice Age: Dawn of the Dinosaurs | $550,000 | $536,601 | -$13,399 | -2.4% | 432 | $193,264,000 | $193,250,211 | 9 | Twentieth Century Fox | - |
| 22 | 22 | - | Aliens in the Attic | $465,000 | $520,563 | +$55,563 | +11.9% | 574 | $22,932,000 | $22,987,502 | 5 | Twentieth Century Fox | - |
| 23 | 25 | +2 | Adam | $365,000 | $345,621 | -$19,379 | -5.3% | 177 | $1,380,000 | $1,360,487 | 5 | Fox Searchlight Pictures | - |
| 24 | 24 | - | A Perfect Getaway | $362,000 | $367,215 | +$5,215 | +1.4% | 544 | $14,996,000 | $15,001,695 | 4 | Universal Pictures | - |
| 25 | 26 | +1 | Funny People | $328,000 | $330,395 | +$2,395 | +0.7% | 413 | $51,322,000 | $51,324,370 | 5 | Universal Pictures | - |
| 26 | 27 | +1 | The Hurt Locker | $287,000 | $280,290 | -$6,710 | -2.3% | 306 | $11,603,000 | $11,595,912 | 10 | Summit Entertainment | - |
| 27 | 31 | +4 | The September Issue | $240,000 | $220,633 | -$19,367 | -8.1% | 6 | $240,000 | $220,633 | 1 | Roadside Attractions | - |
| 28 | 30 | +2 | Night at the Museum: Battle of the Smithsonian | $231,000 | $239,224 | +$8,224 | +3.6% | 232 | $176,454,000 | $176,461,908 | 15 | Twentieth Century Fox | - |
| 29 | 34 | +5 | In the Loop | $197,000 | $149,041 | -$47,959 | -24.3% | 84 | $1,828,000 | $1,779,340 | 6 | IFC Films | - |
| 30 | 32 | +2 | Star Trek | $180,000 | $182,482 | +$2,482 | +1.4% | 218 | $256,670,000 | $256,673,273 | 17 | Paramount Pictures | - |
| 31 | 33 | +2 | Public Enemies | $168,000 | $164,930 | -$3,070 | -1.8% | 264 | $97,033,000 | $97,030,725 | 9 | Universal Pictures | - |
| 32 | 35 | +3 | It Might Get Loud | $133,000 | $123,905 | -$9,095 | -6.8% | 30 | $363,000 | $354,350 | 3 | Sony Pictures Classics | - |
| 33 | 36 | +3 | Bandslam | $124,000 | $118,806 | -$5,194 | -4.2% | 207 | $4,941,000 | $4,935,870 | 3 | Summit Entertainment | - |
| 34 | 38 | +4 | Cold Souls | $100,000 | $97,200 | -$2,800 | -2.8% | 40 | $479,000 | $475,615 | 4 | The Samuel Goldwyn Company | - |
| 35 | 40 | +5 | My One and Only | $86,600 | $79,652 | -$6,948 | -8% | 10 | $173,000 | $165,641 | 2 | Freestyle Releasing | - |
| 36 | 44 | +8 | The Cove | $46,900 | $45,703 | -$1,197 | -2.6% | 25 | $626,000 | $619,467 | 5 | Roadside Attractions | - |
| 37 | 45 | +8 | Moon | $42,600 | $42,268 | -$332 | -0.8% | 49 | $4,653,000 | $4,652,960 | 12 | Sony Pictures Classics | - |
| 38 | 55 | +17 | Big Fan | $26,000 | $24,266 | -$1,734 | -6.7% | 2 | $26,000 | $24,266 | 1 | First Independent Pictures | - |
| 39 | 54 | +15 | Lorna's Silence | $22,500 | $25,362 | +$2,862 | +12.7% | 12 | $197,000 | $199,524 | 5 | Sony Pictures Classics | - |
| 40 | 60 | +20 | Whatever Works | $21,600 | $18,773 | -$2,827 | -13.1% | 21 | $5,223,000 | $5,220,351 | 11 | Sony Pictures Classics | - |
| 41 | 59 | +18 | Still Walking | $21,500 | $20,298 | -$1,202 | -5.6% | 2 | $21,500 | $20,298 | 1 | IFC Films | - |
| 42 | 74 | +32 | Tetro | $10,000 | $10,104 | +$104 | +1% | 8 | $455,000 | $454,823 | 12 | American Zoetrope | - |
| 43 | 80 | +37 | We Live in Public | $8,300 | $7,325 | -$975 | -11.7% | 1 | $8,300 | $7,325 | 1 | Abramorama | - |
| 44 | 78 | +34 | Mystery Team | $7,900 | $7,840 | -$60 | -0.8% | 1 | $7,900 | $7,840 | 1 | Roadside Attractions | - |
