| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Inglourious Basterds | $46,800 | - | 5 | - | $9,360 | $82,169 | 1 | United International Pictures | true | false |
| 2 | - | Up | $39,930 | - | 10 | - | $3,993 | $46,303 | 1 | Walt Disney Pictures | true | false |
| 3 | 2 | The Girl with the Dragon Tattoo | $9,962 | -18.2% | 4 | - | $2,490 | $276,591 | 6 | N/A | false | false |
| 4 | 1 | Drag Me to Hell | $7,666 | -57.2% | 3 | - | $2,555 | $54,513 | 2 | N/A | false | false |
| 5 | 5 | The Proposal | $5,098 | -49.5% | 6 | - | $849 | $209,672 | 5 | Walt Disney Pictures | false | false |
| 6 | 4 | The Taking of Pelham 123 | $3,825 | -64.7% | 4 | - | $956 | $27,187 | 2 | Sony Pictures Releasing | false | false |
| 7 | 6 | G.I. Joe: The Rise of Cobra | $3,329 | -63.6% | 5 | - | $665 | $69,796 | 3 | United International Pictures | false | false |
| 8 | 8 | Public Enemies | $2,857 | -52.5% | 5 | - | $571 | $138,365 | 4 | United International Pictures | false | false |
| 9 | 10 | Ice Age: Dawn of the Dinosaurs | $2,572 | -41.4% | 7 | - | $367 | $262,972 | 9 | 20th Century Fox International | false | false |
| 10 | 3 | G-Force | $2,569 | -78.4% | 4 | +1 | $642 | $109,812 | 4 | Walt Disney Pictures | false | false |
| 11 | 9 | The Time Traveler's Wife | $2,356 | -51.7% | 2 | - | $1,178 | $11,996 | 2 | N/A | false | false |
| 12 | 7 | The Goods: Live Hard, Sell Hard | $1,682 | -73.6% | 2 | - | $841 | $14,241 | 2 | N/A | false | false |
| 13 | 11 | Harry Potter and the Half-Blood Prince | $884 | -78.7% | 2 | -2 | $442 | $320,358 | 7 | Warner Bros. | false | false |
| 14 | 13 | The Hangover | $868 | +15.4% | 1 | - | $868 | $411,116 | 12 | Warner Bros. | false | false |
| 15 | 12 | My Sister's Keeper | $587 | -47.6% | 1 | -2 | $587 | $90,406 | 8 | N/A | false | false |
| 16 | 14 | Funny Games | $226 | -31.1% | 1 | - | $226 | $10,930 | 4 | N/A | false | false |
