| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Proposal | $83,425 | -51.3% | 30 | - | $2,780 | $665,002 | 3 | Walt Disney Pictures | false | false |
| 2 | 3 | The Hangover | $40,758 | -48.9% | 15 | - | $2,717 | $171,217 | 2 | Warner Bros. | false | false |
| 3 | 2 | G.I. Joe: The Rise of Cobra | $33,405 | -60.3% | 22 | -18 | $1,518 | $1,904,363 | 5 | United International Pictures | false | false |
| 4 | 4 | Orphan | $31,681 | -50% | 20 | -10 | $1,584 | $451,595 | 4 | Warner Bros. | false | false |
| 5 | 11 | Transformers: Revenge of the Fallen | $6,111 | +742.9% | 3 | +2 | $2,037 | $4,460,090 | 11 | United International Pictures | false | false |
| 6 | 7 | Up | $5,735 | -70.3% | 5 | -7 | $1,147 | $1,476,277 | 6 | Walt Disney Pictures | false | false |
| 7 | 5 | Land of the Lost | $3,961 | -89.5% | 6 | -9 | $660 | $114,678 | 3 | United International Pictures | false | false |
| 8 | 8 | Ice Age: Dawn of the Dinosaurs | $2,117 | -72% | 2 | - | $1,058 | $2,109,254 | 10 | 20th Century Fox International | false | false |
| 9 | 9 | Public Enemies | $1,417 | -68% | 1 | -1 | $1,417 | $629,496 | 7 | United International Pictures | false | false |
| 10 | 6 | The Taking of Pelham 123 | $1,177 | -95.3% | 5 | -17 | $235 | $389,762 | 4 | Sony Pictures Releasing | false | false |
| 11 | 10 | Harry Potter and the Half-Blood Prince | $1,041 | -64.4% | 2 | - | $520 | $3,522,641 | 8 | Warner Bros. | false | false |
| 12 | 12 | Aliens in the Attic | $508 | +257.7% | 1 | - | $508 | $185,232 | 5 | 20th Century Fox International | false | false |
