| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Orphan | $103,593 | - | 24 | - | $4,316 | $103,593 | 1 | Warner Bros. | true | false |
| 2 | 2 | The Hangover | $90,492 | -6.7% | 28 | +1 | $3,231 | $216,419 | 2 | Warner Bros. | false | false |
| 3 | 1 | G-Force | $72,897 | -24.9% | 44 | -1 | $1,656 | $1,350,097 | 6 | Walt Disney Pictures | false | false |
| 4 | - | Aliens in the Attic | $71,222 | - | 31 | - | $2,297 | $73,403 | 1 | 20th Century Fox International | true | false |
| 5 | 3 | The Maid | $55,303 | -34.7% | 20 | - | $2,765 | $284,961 | 3 | Andes Films | false | false |
| 6 | 5 | Ice Age: Dawn of the Dinosaurs | $36,608 | -25.3% | 43 | -6 | $851 | $7,032,474 | 9 | 20th Century Fox International | false | false |
| 7 | - | Last Chance Harvey | $36,244 | - | 10 | - | $3,624 | $36,244 | 1 | N/A | true | false |
| 8 | 7 | The Proposal | $28,160 | -32.7% | 24 | -4 | $1,173 | $258,638 | 4 | Walt Disney Pictures | false | false |
| 9 | 8 | Public Enemies | $25,632 | -37.8% | 21 | -6 | $1,220 | $470,651 | 5 | United International Pictures | false | false |
| 10 | 4 | G.I. Joe: The Rise of Cobra | $24,989 | -52.9% | 36 | -9 | $694 | $410,325 | 4 | United International Pictures | false | false |
| 11 | 6 | My Bloody Valentine | $19,795 | -58.9% | 22 | -5 | $899 | $80,718 | 2 | N/A | false | false |
| 12 | 10 | Shorts | $18,312 | -35.2% | 25 | -4 | $732 | $205,924 | 4 | Warner Bros. | false | false |
| 13 | 9 | Harry Potter and the Half-Blood Prince | $17,493 | -38.3% | 181 | +152 | $96 | $3,575,000 | 7 | Warner Bros. | false | false |
| 14 | - | Transporter 3 | $16,757 | - | 10 | - | $1,675 | $16,757 | 1 | N/A | true | false |
| 15 | 12 | State of Play | $10,627 | -31.8% | 13 | -3 | $817 | $74,555 | 3 | United International Pictures | false | false |
| 16 | 11 | Bangkok Dangerous | $5,888 | -62.7% | 10 | -6 | $588 | $73,896 | 3 | N/A | false | false |
| 17 | 15 | Up | $4,578 | -10.4% | 6 | -1 | $763 | $3,752,284 | 12 | Walt Disney Pictures | false | false |
| 18 | 13 | Grade 3 | $1,695 | -80.9% | 5 | -11 | $339 | $1,180,831 | 8 | N/A | false | false |
