| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Ice Age: Dawn of the Dinosaurs | $10,497 | -27.3% | 9 | - | $1,166 | $314,500 | 7 | 20th Century Fox International | false | false |
| 2 | 3 | Harry Potter and the Half-Blood Prince | $6,354 | -24% | 8 | - | $794 | $159,809 | 5 | Warner Bros. | false | false |
| 3 | 2 | The Proposal | $6,078 | -33.4% | 6 | - | $1,013 | $67,835 | 4 | Walt Disney Pictures | false | false |
| 4 | 7 | Public Enemies | $3,101 | +59.7% | 5 | - | $620 | $57,877 | 7 | United International Pictures | false | false |
| 5 | 6 | The Hangover | $2,525 | -3.4% | 5 | - | $505 | $129,489 | 9 | Warner Bros. | false | false |
| 6 | 5 | Knowing | $2,447 | -28.9% | 4 | - | $611 | $17,213 | 3 | N/A | false | false |
| 7 | 4 | Brüno | $2,283 | -39% | 6 | - | $380 | $58,387 | 6 | N/A | false | false |
| 8 | 9 | Angels & Demons | $833 | +41.7% | 6 | +3 | $138 | $163,136 | 14 | Sony Pictures Releasing | false | false |
| 9 | 8 | Transformers: Revenge of the Fallen | $759 | -44.7% | 8 | - | $94 | $80,907 | 8 | United International Pictures | false | false |
| 10 | 10 | Coraline | $560 | +13.6% | 4 | - | $140 | $31,667 | 11 | United International Pictures | false | false |
| 11 | 11 | Terminator Salvation | $415 | -10.9% | 4 | -2 | $103 | $90,391 | 11 | Sony Pictures Releasing | false | false |
| 12 | 13 | Hannah Montana: The Movie | $305 | -15.3% | 5 | - | $61 | $30,801 | 10 | Walt Disney Pictures | false | false |
| 13 | 12 | Ghosts of Girlfriends Past | $217 | -48.7% | 5 | - | $43 | $55,581 | 10 | Warner Bros. | false | false |
| 14 | 18 | State of Play | $178 | +2.9% | 4 | - | $44 | $26,949 | 10 | United International Pictures | false | false |
| 15 | 17 | Night at the Museum: Battle of the Smithsonian | $127 | -29.8% | 6 | - | $21 | $60,222 | 13 | 20th Century Fox International | false | false |
| 16 | 16 | 17 Again | $107 | -58.4% | 5 | - | $21 | $31,706 | 17 | Warner Bros. | false | false |
| 17 | 15 | Diamond 13 | $85 | -69.8% | 2 | - | $42 | $1,451 | 14 | N/A | false | false |
| 18 | 14 | Slumdog Millionaire | $68 | -78.3% | 5 | - | $13 | $64,685 | 18 | N/A | false | false |
| 19 | - | The Belgrade Phantom | $52 | - | 5 | - | $10 | $137,698 | 20 | N/A | false | false |
| 20 | 19 | Taken | $42 | -48.1% | 2 | - | $21 | $4,927 | 9 | N/A | false | false |
| 21 | 20 | Hotel for Dogs | $22 | -67.6% | 6 | - | $3 | $33,647 | 17 | United International Pictures | false | false |
