| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Proposal | $198,248 | - | 30 | - | $6,608 | $265,562 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | G.I. Joe: The Rise of Cobra | $183,047 | -54% | 40 | - | $4,576 | $1,709,750 | 3 | United International Pictures | false | false |
| 3 | 4 | Orphan | $88,125 | -1.1% | 31 | - | $2,842 | $284,973 | 2 | Warner Bros. | false | false |
| 4 | 2 | The Taking of Pelham 123 | $86,307 | -52.6% | 25 | - | $3,452 | $348,332 | 2 | Sony Pictures Releasing | false | false |
| 5 | 3 | Up | $67,475 | -54.5% | 25 | -14 | $2,699 | $1,454,088 | 4 | Walt Disney Pictures | false | false |
| 6 | - | Land of the Lost | $43,795 | - | 15 | - | $2,919 | $47,245 | 1 | United International Pictures | true | false |
| 7 | 10 | Ice Age: Dawn of the Dinosaurs | $9,861 | +14% | 6 | +3 | $1,643 | $2,131,531 | 8 | 20th Century Fox International | false | false |
| 8 | 7 | Harry Potter and the Half-Blood Prince | $7,128 | -55.1% | 9 | -16 | $792 | $3,579,804 | 6 | Warner Bros. | false | false |
| 9 | 5 | Aliens in the Attic | $5,944 | -80.4% | 8 | -10 | $743 | $186,795 | 3 | 20th Century Fox International | false | false |
| 10 | 9 | Transformers: Revenge of the Fallen | $4,835 | -45.3% | 6 | +3 | $805 | $4,533,853 | 9 | United International Pictures | false | false |
| 11 | 8 | Public Enemies | $1,067 | -90.1% | 1 | -8 | $1,067 | $631,603 | 5 | United International Pictures | false | false |
