| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | G.I. Joe: The Rise of Cobra | $56,200,000 | $54,713,046 | -$1,486,954 | -2.6% | 4,007 | $56,200,000 | $54,713,046 | 1 | Paramount Pictures | - |
| 2 | 2 | - | Julie & Julia | $20,100,000 | $20,027,956 | -$72,044 | -0.4% | 2,354 | $20,100,000 | $20,027,956 | 1 | Sony Pictures Releasing | - |
| 3 | 3 | - | G-Force | $9,804,000 | $9,870,594 | +$66,594 | +0.7% | 3,482 | $86,116,000 | $86,183,076 | 3 | Walt Disney Studios Motion Pictures | - |
| 4 | 4 | - | Harry Potter and the Half-Blood Prince | $8,880,000 | $8,928,349 | +$48,349 | +0.5% | 3,455 | $273,800,000 | $273,848,633 | 4 | Warner Bros. | - |
| 5 | 5 | - | Funny People | $7,866,000 | $7,986,435 | +$120,435 | +1.5% | 3,008 | $40,417,000 | $40,537,755 | 2 | Universal Pictures | - |
| 6 | 6 | - | The Ugly Truth | $7,000,000 | $6,750,125 | -$249,875 | -3.6% | 2,975 | $69,088,000 | $68,838,257 | 3 | Sony Pictures Releasing | - |
| 7 | 7 | - | A Perfect Getaway | $5,765,000 | $5,948,555 | +$183,555 | +3.2% | 2,159 | $5,765,000 | $5,948,555 | 1 | Universal Pictures | - |
| 8 | 8 | - | Aliens in the Attic | $4,000,000 | $4,021,478 | +$21,478 | +0.5% | 3,108 | $16,293,000 | $16,314,371 | 2 | Twentieth Century Fox | - |
| 9 | 10 | +1 | Orphan | $3,730,000 | $3,674,306 | -$55,694 | -1.5% | 2,270 | $34,822,000 | $34,766,199 | 3 | Warner Bros. | - |
| 10 | 9 | -1 | 500 Days of Summer | $3,725,000 | $3,739,702 | +$14,702 | +0.4% | 817 | $12,343,000 | $12,357,265 | 4 | Fox Searchlight Pictures | - |
| 11 | 11 | - | The Hangover | $3,400,000 | $3,369,178 | -$30,822 | -0.9% | 1,690 | $262,010,000 | $261,979,331 | 10 | Warner Bros. | - |
| 12 | 12 | - | Transformers: Revenge of the Fallen | $3,000,000 | $3,008,825 | +$8,825 | +0.3% | 1,948 | $393,701,000 | $393,709,339 | 7 | DreamWorks | - |
| 13 | 13 | - | The Proposal | $2,874,000 | $2,825,483 | -$48,517 | -1.7% | 1,870 | $154,799,000 | $154,751,286 | 8 | Walt Disney Studios Motion Pictures | - |
| 14 | 14 | - | Ice Age: Dawn of the Dinosaurs | $2,550,000 | $2,670,160 | +$120,160 | +4.7% | 1,727 | $187,751,000 | $187,871,005 | 6 | Twentieth Century Fox | - |
| 15 | 15 | - | The Collector | $1,477,000 | $1,275,753 | -$201,247 | -13.6% | 1,270 | $6,553,000 | $6,351,293 | 2 | Freestyle Releasing | - |
| 16 | 16 | - | The Hurt Locker | $1,260,000 | $1,260,820 | +$820 | <0.1% | 535 | $8,987,000 | $8,987,925 | 7 | Summit Entertainment | - |
| 17 | 17 | - | Public Enemies | $992,000 | $987,665 | -$4,335 | -0.4% | 906 | $95,496,000 | $95,491,810 | 6 | Universal Pictures | - |
| 18 | 19 | +1 | Up | $620,000 | $624,966 | +$4,966 | +0.8% | 431 | $287,387,000 | $287,392,452 | 11 | Walt Disney Studios Motion Pictures | - |
| 19 | 20 | +1 | Night at the Museum: Battle of the Smithsonian | $460,000 | $467,057 | +$7,057 | +1.5% | 329 | $174,850,000 | $174,856,646 | 12 | Twentieth Century Fox | - |
| 20 | 21 | +1 | Star Trek | $421,000 | $438,654 | +$17,654 | +4.2% | 375 | $255,310,000 | $255,327,784 | 14 | Paramount Pictures | - |
| 21 | 25 | +4 | Paper Heart | $206,000 | $219,494 | +$13,494 | +6.6% | 38 | $206,000 | $219,494 | 1 | Overture Films | - |
| 22 | 27 | +5 | Brüno | $201,000 | $193,030 | -$7,970 | -4% | 199 | $59,795,000 | $59,786,610 | 5 | Universal Pictures | - |
| 23 | 29 | +6 | Moon | $171,000 | $165,430 | -$5,570 | -3.3% | 139 | $4,258,000 | $4,252,965 | 9 | Sony Pictures Classics | - |
| 24 | 31 | +7 | The Cove | $158,000 | $161,732 | +$3,732 | +2.4% | 56 | $240,000 | $244,062 | 2 | Roadside Attractions | - |
| 25 | 34 | +9 | Adam | $104,000 | $104,178 | +$178 | +0.2% | 20 | $242,000 | $242,251 | 2 | Fox Searchlight Pictures | - |
| 26 | 36 | +10 | Whatever Works | $101,000 | $94,649 | -$6,351 | -6.3% | 84 | $5,015,000 | $5,008,979 | 8 | Sony Pictures Classics | - |
| 27 | 35 | +8 | Imagine That | $97,000 | $95,192 | -$1,808 | -1.9% | 137 | $15,975,000 | $15,972,486 | 9 | Paramount Pictures | - |
| 28 | 38 | +10 | Monsters vs. Aliens | $81,000 | $78,316 | -$2,684 | -3.3% | 140 | $198,139,000 | $198,135,894 | 20 | DreamWorks | - |
| 29 | 39 | +10 | Land of the Lost | $73,000 | $73,140 | +$140 | +0.2% | 125 | $49,392,000 | $49,392,095 | 10 | Universal Pictures | - |
| 30 | 40 | +10 | Away We Go | $68,600 | $72,169 | +$3,569 | +5.2% | 97 | $9,355,000 | $9,358,424 | 10 | Focus Features | - |
| 31 | 41 | +10 | Cold Souls | $63,300 | $63,302 | +$2 | <0.1% | 7 | $63,300 | $63,302 | 1 | The Samuel Goldwyn Company | - |
| 32 | 43 | +11 | Thirst | $51,800 | $54,916 | +$3,116 | +6% | 8 | $138,000 | $140,718 | 2 | Focus Features | - |
| 33 | 49 | +16 | Chéri | $33,700 | $34,427 | +$727 | +2.2% | 54 | $2,643,000 | $2,643,292 | 7 | Miramax | - |
| 34 | 53 | +19 | Lorna's Silence | $22,900 | $21,931 | -$969 | -4.2% | 9 | $75,800 | $74,754 | 2 | Sony Pictures Classics | - |
| 35 | 57 | +22 | Shrink | $19,800 | $19,937 | +$137 | +0.7% | 25 | $146,000 | $146,543 | 3 | Roadside Attractions | - |
| 36 | 60 | +24 | Tetro | $12,500 | $13,324 | +$824 | +6.6% | 14 | $392,000 | $393,013 | 9 | American Zoetrope | - |
| 37 | 63 | +26 | The Stoning of Soraya M. | $11,800 | $11,268 | -$532 | -4.5% | 12 | $599,000 | $598,669 | 7 | Roadside Attractions | - |
| 38 | 65 | +27 | War Eagle, Arkansas | $10,200 | $10,439 | +$239 | +2.3% | 3 | $110,000 | $109,788 | 9 | Hannover House | - |
| 39 | 77 | +38 | Unmistaken Child | $3,800 | $5,337 | +$1,537 | +40.4% | 3 | $188,000 | $189,708 | 10 | Oscilloscope | - |
| 40 | 102 | +62 | Burma VJ: Reporting from a Closed Country | $1,400 | $1,146 | -$254 | -18.1% | 2 | $50,700 | $50,436 | 12 | Oscilloscope | - |
