| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Ice Age: Dawn of the Dinosaurs | $14,430 | +14.3% | 9 | - | $1,603 | $291,979 | 6 | 20th Century Fox International | false | false |
| 2 | 3 | The Proposal | $9,126 | +17% | 6 | - | $1,521 | $53,455 | 3 | Walt Disney Pictures | false | false |
| 3 | 2 | Harry Potter and the Half-Blood Prince | $8,363 | -14.1% | 8 | - | $1,045 | $145,916 | 4 | Warner Bros. | false | false |
| 4 | 4 | Brüno | $3,744 | +9.2% | 6 | - | $624 | $52,646 | 5 | N/A | false | false |
| 5 | 5 | Knowing | $3,441 | +14.8% | 4 | +3 | $860 | $53,758 | 2 | N/A | false | false |
| 6 | 6 | The Hangover | $2,614 | +12.1% | 5 | - | $522 | $124,528 | 8 | Warner Bros. | false | false |
| 7 | 7 | Public Enemies | $1,942 | -9.6% | 5 | - | $388 | $51,501 | 6 | United International Pictures | false | false |
| 8 | 8 | Transformers: Revenge of the Fallen | $1,372 | +3.6% | 8 | - | $171 | $79,583 | 7 | United International Pictures | false | false |
| 9 | 12 | Angels & Demons | $588 | +62.9% | 3 | - | $196 | $161,969 | 13 | Sony Pictures Releasing | false | false |
| 10 | 13 | Coraline | $493 | +45.4% | 4 | - | $123 | $30,331 | 10 | United International Pictures | false | false |
| 11 | 9 | Terminator Salvation | $466 | +5.9% | 6 | - | $77 | $89,711 | 10 | Sony Pictures Releasing | false | false |
| 12 | 11 | Ghosts of Girlfriends Past | $423 | +10.4% | 5 | - | $84 | $54,807 | 9 | Warner Bros. | false | false |
| 13 | 14 | Hannah Montana: The Movie | $360 | +13.6% | 5 | - | $72 | $29,770 | 9 | Walt Disney Pictures | false | false |
| 14 | 18 | Slumdog Millionaire | $314 | +103.9% | 5 | - | $62 | $64,485 | 17 | N/A | false | false |
| 15 | - | Diamond 13 | $281 | - | 2 | - | $140 | $1,067 | 13 | N/A | false | false |
| 16 | 20 | 17 Again | $257 | +314.5% | 5 | - | $51 | $31,592 | 16 | Warner Bros. | false | false |
| 17 | 16 | Night at the Museum: Battle of the Smithsonian | $181 | -27.9% | 6 | - | $30 | $59,452 | 12 | 20th Century Fox International | false | false |
| 18 | 19 | State of Play | $173 | +27.2% | 4 | - | $43 | $26,568 | 9 | United International Pictures | false | false |
| 19 | 10 | Taken | $81 | -80.1% | 2 | - | $40 | $4,712 | 8 | N/A | false | false |
| 20 | 15 | Hotel for Dogs | $68 | -77.9% | 6 | - | $11 | $33,600 | 16 | United International Pictures | false | false |
| 21 | 21 | The Boat That Rocked | $63 | +70.3% | 6 | - | $10 | $7,549 | 8 | United International Pictures | false | false |
| 22 | - | Monsters vs. Aliens | $19 | - | 5 | - | $3 | $37,549 | 20 | United International Pictures | false | false |
