| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Ice Age: Dawn of the Dinosaurs | $20,613 | -47.3% | 12 | -1 | $1,717 | $1,184,960 | 6 | Universal Pictures International (UPI) | false | false |
| 2 | - | My Sister's Keeper | $12,996 | - | 4 | - | $3,249 | $12,996 | 1 | - | true | false |
| 3 | - | Year One | $12,327 | - | 7 | - | $1,761 | $12,327 | - | Sony Pictures Releasing | - | false |
| 4 | 3 | Harry Potter and the Half-Blood Prince | $8,401 | -44% | 8 | - | $1,050 | $253,936 | 3 | Garsu Pasaulio Irasai | false | false |
| 5 | 2 | The Taking of Pelham 123 | $7,469 | -51% | 7 | - | $1,067 | $36,516 | 2 | Sony Pictures Releasing | false | false |
| 6 | 4 | Brüno | $6,178 | -54.6% | 7 | - | $882 | $117,998 | 3 | ACME | false | false |
| 7 | - | Diary of a Nymphomaniac | $3,186 | - | 2 | - | $1,593 | $3,896 | 1 | ACME | true | false |
| 8 | 7 | Easy Virtue | $1,814 | -44.9% | 2 | - | $907 | $10,398 | 2 | ACME | false | false |
| 9 | 5 | Hannah Montana: The Movie | $1,787 | -68.4% | 3 | - | $595 | $14,367 | 2 | Universal Pictures International (UPI) | false | false |
| 10 | - | Fly Me to the Moon 3D | $1,512 | - | 2 | - | $756 | $126,489 | 29 | Universal Pictures International (UPI) | false | false |
| 11 | 9 | Public Enemies | $1,478 | -38.3% | 6 | -1 | $246 | $83,509 | 5 | Universal Pictures International (UPI) | false | false |
| 12 | 6 | The Hangover | $1,475 | -66.9% | 4 | -1 | $368 | $284,982 | 9 | - | false | false |
| 13 | 8 | The Last House on the Left | $1,329 | -49.4% | 3 | - | $443 | $19,164 | 3 | Universal Pictures International (UPI) | false | false |
| 14 | 12 | The Proposal | $742 | -45.1% | 2 | -3 | $371 | $152,786 | 8 | Universal Pictures International (UPI) | false | false |
| 15 | 11 | Gomorrah | $543 | -63.4% | 2 | - | $271 | $20,408 | 4 | Universal Pictures International (UPI) | false | false |
| 16 | 10 | Transformers: Revenge of the Fallen | $532 | -71.9% | 4 | -1 | $133 | $218,420 | 7 | Universal Pictures International (UPI) | false | false |
| 17 | - | U2 3D | $419 | - | 2 | - | $209 | $61,083 | 29 | Universal Pictures International (UPI) | false | false |
| 18 | 13 | The Uninvited | $56 | -85.6% | 1 | - | $56 | $22,437 | 12 | Universal Pictures International (UPI) | false | false |
| 19 | - | Confessions of a Shopaholic | $41 | - | 1 | - | $41 | $82,855 | 18 | Universal Pictures International (UPI) | false | false |
| 20 | 16 | Beverly Hills Chihuahua | $10 | -41.2% | 1 | - | $10 | $135,949 | 27 | Universal Pictures International (UPI) | false | false |
