| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Funny People | $23,440,000 | $22,657,780 | -$782,220 | -3.3% | 3,007 | $23,440,000 | $22,657,780 | 1 | Universal Pictures | - |
| 2 | 2 | - | Harry Potter and the Half-Blood Prince | $17,700,000 | $17,909,385 | +$209,385 | +1.2% | 4,393 | $255,463,000 | $255,672,245 | 3 | Warner Bros. | - |
| 3 | 3 | - | G-Force | $17,058,000 | $17,515,489 | +$457,489 | +2.7% | 3,697 | $66,461,000 | $66,918,912 | 2 | Walt Disney Studios Motion Pictures | - |
| 4 | 4 | - | The Ugly Truth | $13,000,000 | $13,187,433 | +$187,433 | +1.4% | 2,882 | $54,481,000 | $54,668,841 | 2 | Sony Pictures Releasing | - |
| 5 | 5 | - | Aliens in the Attic | $7,800,000 | $8,008,423 | +$208,423 | +2.7% | 3,106 | $7,800,000 | $8,008,423 | 1 | Twentieth Century Fox | - |
| 6 | 6 | - | Orphan | $7,250,000 | $7,525,419 | +$275,419 | +3.8% | 2,750 | $26,791,000 | $27,066,812 | 2 | Warner Bros. | - |
| 7 | 7 | - | Ice Age: Dawn of the Dinosaurs | $5,300,000 | $5,526,015 | +$226,015 | +4.3% | 2,757 | $181,843,000 | $182,068,804 | 5 | Twentieth Century Fox | - |
| 8 | 8 | - | The Hangover | $5,080,000 | $5,194,475 | +$114,475 | +2.3% | 2,071 | $255,776,000 | $255,890,892 | 9 | Warner Bros. | - |
| 9 | 9 | - | The Proposal | $4,848,000 | $4,931,064 | +$83,064 | +1.7% | 2,435 | $148,882,000 | $148,964,741 | 7 | Walt Disney Studios Motion Pictures | - |
| 10 | 10 | - | Transformers: Revenge of the Fallen | $4,600,000 | $4,688,329 | +$88,329 | +1.9% | 2,626 | $388,101,000 | $388,189,320 | 6 | DreamWorks | - |
| 11 | 11 | - | The Collector | $3,625,000 | $3,576,296 | -$48,704 | -1.3% | 1,325 | $3,625,000 | $3,576,296 | 1 | Freestyle Releasing | - |
| 12 | 12 | - | 500 Days of Summer | $2,750,000 | $2,776,891 | +$26,891 | +1% | 266 | $6,821,000 | $6,847,506 | 3 | Fox Searchlight Pictures | - |
| 13 | 13 | - | Public Enemies | $2,446,000 | $2,527,310 | +$81,310 | +3.3% | 1,620 | $93,119,000 | $93,199,665 | 5 | Universal Pictures | - |
| 14 | 14 | - | The Hurt Locker | $1,911,000 | $1,909,170 | -$1,830 | <0.1% | 523 | $6,757,000 | $6,755,335 | 6 | Summit Entertainment | - |
| 15 | 16 | +1 | Up | $1,135,000 | $1,174,631 | +$39,631 | +3.5% | 726 | $286,013,000 | $286,053,296 | 10 | Walt Disney Studios Motion Pictures | - |
| 16 | 17 | +1 | Brüno | $870,000 | $885,210 | +$15,210 | +1.7% | 747 | $59,082,000 | $59,097,200 | 4 | Universal Pictures | - |
| 17 | 18 | +1 | My Sister's Keeper | $645,000 | $658,003 | +$13,003 | +2% | 656 | $46,737,000 | $46,749,509 | 6 | Warner Bros. | - |
| 18 | 19 | +1 | Night at the Museum: Battle of the Smithsonian | $535,000 | $558,360 | +$23,360 | +4.4% | 349 | $173,990,000 | $174,013,037 | 11 | Twentieth Century Fox | - |
| 19 | 24 | +5 | In the Loop | $309,000 | $291,012 | -$17,988 | -5.8% | 35 | $590,000 | $571,602 | 2 | IFC Films | - |
| 20 | 21 | +1 | Star Trek | $307,000 | $327,377 | +$20,377 | +6.6% | 228 | $254,642,000 | $254,661,846 | 13 | Paramount Pictures | - |
| 21 | 26 | +5 | I Love You, Beth Cooper | $287,000 | $283,365 | -$3,635 | -1.3% | 304 | $14,195,000 | $14,191,592 | 4 | Twentieth Century Fox | - |
| 22 | 27 | +5 | Moon | $276,000 | $279,147 | +$3,147 | +1.1% | 194 | $3,915,000 | $3,919,083 | 8 | Sony Pictures Classics | - |
| 23 | 29 | +6 | Whatever Works | $208,000 | $202,168 | -$5,832 | -2.8% | 146 | $4,816,000 | $4,810,057 | 7 | Sony Pictures Classics | - |
| 24 | 31 | +7 | Away We Go | $148,000 | $157,538 | +$9,538 | +6.4% | 142 | $9,194,000 | $9,199,627 | 9 | Focus Features | - |
| 25 | 32 | +7 | Land of the Lost | $130,000 | $131,095 | +$1,095 | +0.8% | 186 | $49,240,000 | $49,240,760 | 9 | Universal Pictures | - |
| 26 | 33 | +7 | Imagine That | $109,000 | $114,916 | +$5,916 | +5.4% | 179 | $15,783,000 | $15,789,261 | 8 | Paramount Pictures | - |
| 27 | 34 | +7 | Chéri | $100,000 | $103,618 | +$3,618 | +3.6% | 107 | $2,552,000 | $2,556,260 | 6 | Miramax | - |
| 28 | 36 | +8 | Monsters vs. Aliens | $90,000 | $91,322 | +$1,322 | +1.5% | 155 | $197,986,000 | $197,987,264 | 19 | DreamWorks | - |
| 29 | 35 | +6 | Drag Me to Hell | $90,000 | $91,615 | +$1,615 | +1.8% | 111 | $42,055,000 | $42,057,340 | 10 | Universal Pictures | - |
| 30 | 40 | +10 | Shrink | $72,400 | $69,394 | -$3,006 | -4.2% | 27 | $96,300 | $93,250 | 2 | Roadside Attractions | - |
| 31 | 41 | +10 | Adam | $66,300 | $68,377 | +$2,077 | +3.1% | 4 | $94,800 | $96,888 | 1 | Fox Searchlight Pictures | - |
| 32 | 44 | +12 | The Cove | $55,500 | $57,640 | +$2,140 | +3.9% | 4 | $55,500 | $57,640 | 1 | Roadside Attractions | - |
| 33 | 45 | +12 | Thirst | $55,200 | $55,889 | +$689 | +1.2% | 4 | $55,200 | $55,889 | 1 | Focus Features | - |
| 34 | 52 | +18 | Lorna's Silence | $36,200 | $34,411 | -$1,789 | -4.9% | 6 | $36,200 | $34,411 | 1 | Sony Pictures Classics | - |
| 35 | 55 | +20 | The Stoning of Soraya M. | $26,500 | $25,837 | -$663 | -2.5% | 20 | $573,000 | $572,391 | 6 | Roadside Attractions | - |
| 36 | 57 | +21 | War Eagle, Arkansas | $22,600 | $22,421 | -$179 | -0.8% | 4 | $96,900 | $96,701 | 8 | Hannover House | - |
| 37 | 65 | +28 | Flame & Citron | $13,600 | $15,254 | +$1,654 | +12.2% | 2 | $13,600 | $15,254 | 1 | IFC Films | - |
| 38 | 67 | +29 | Tetro | $11,300 | $12,800 | +$1,500 | +13.3% | 9 | $371,000 | $372,122 | 8 | American Zoetrope | - |
| 39 | 72 | +33 | Herb & Dorothy | $10,300 | $9,968 | -$332 | -3.2% | 8 | $148,000 | $147,623 | 9 | Arthouse Films | - |
