| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Ice Age: Dawn of the Dinosaurs | $12,629 | - | 9 | - | $1,403 | $263,167 | 5 | 20th Century Fox International | false | false |
| 2 | - | Harry Potter and the Half-Blood Prince | $9,733 | - | 8 | - | $1,216 | $127,134 | 3 | Warner Bros. | false | false |
| 3 | - | The Proposal | $7,801 | - | 6 | - | $1,300 | $33,991 | 2 | Walt Disney Pictures | false | false |
| 4 | - | Brüno | $3,430 | - | 6 | - | $571 | $46,939 | 4 | N/A | false | false |
| 5 | - | Knowing | $2,997 | - | 1 | - | $2,997 | $3,977 | 1 | N/A | true | false |
| 6 | - | The Hangover | $2,332 | - | 5 | - | $466 | $117,974 | 7 | Warner Bros. | false | false |
| 7 | - | Public Enemies | $2,149 | - | 5 | - | $429 | $46,902 | 5 | United International Pictures | false | false |
| 8 | - | Transformers: Revenge of the Fallen | $1,324 | - | 8 | - | $165 | $76,532 | 6 | United International Pictures | false | false |
| 9 | - | Terminator Salvation | $440 | - | 6 | - | $73 | $88,908 | 9 | Sony Pictures Releasing | false | false |
| 10 | - | Taken | $407 | - | 2 | - | $203 | $4,265 | 7 | N/A | false | false |
| 11 | - | Ghosts of Girlfriends Past | $383 | - | 5 | - | $76 | $53,835 | 8 | Warner Bros. | false | false |
| 12 | - | Angels & Demons | $361 | - | 3 | - | $120 | $161,111 | 12 | Sony Pictures Releasing | false | false |
| 13 | - | Coraline | $339 | - | 4 | - | $84 | $29,165 | 9 | United International Pictures | false | false |
| 14 | - | Hannah Montana: The Movie | $317 | - | 5 | - | $63 | $28,660 | 8 | Walt Disney Pictures | false | false |
| 15 | - | Hotel for Dogs | $308 | - | 6 | - | $51 | $33,508 | 15 | United International Pictures | false | false |
| 16 | - | Night at the Museum: Battle of the Smithsonian | $251 | - | 6 | - | $41 | $58,685 | 11 | 20th Century Fox International | false | false |
| 17 | - | The Belgrade Phantom | $177 | - | 5 | - | $35 | $137,569 | 18 | N/A | false | false |
| 18 | - | Slumdog Millionaire | $154 | - | 5 | - | $30 | $64,159 | 16 | N/A | false | false |
| 19 | - | State of Play | $136 | - | 4 | - | $34 | $26,266 | 8 | United International Pictures | false | false |
| 20 | - | 17 Again | $62 | - | 5 | - | $12 | $31,255 | 15 | Warner Bros. | false | false |
| 21 | - | The Boat That Rocked | $37 | - | 6 | - | $6 | $7,481 | 7 | United International Pictures | false | false |
| 22 | - | Star Trek | $17 | - | 5 | - | $3 | $43,749 | 13 | United International Pictures | false | false |
