| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Public Enemies | $1,063,558 | -55.6% | 415 | +17 | $2,562 | $4,413,977 | 2 | Universal Pictures International (UPI) | false | false |
| 2 | 1 | Harry Potter and the Half-Blood Prince | $1,053,711 | -64.3% | 632 | -263 | $1,667 | $17,350,109 | 3 | Karo Premiere | false | false |
| 3 | - | Ghosts of Girlfriends Past | $1,023,322 | - | 316 | - | $3,238 | $1,023,322 | 8 | Karo Premiere | false | false |
| 4 | 3 | Ice Age: Dawn of the Dinosaurs | $641,885 | -49% | 200 | -507 | $3,209 | $43,211,488 | 5 | 20th Century Fox International | false | false |
| 5 | - | Aliens in the Attic | $487,443 | - | 351 | - | $1,388 | $487,443 | - | 20th Century Fox International | - | false |
| 6 | - | Funny People | $387,292 | - | 203 | - | $1,907 | $387,292 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 4 | Brüno | $220,147 | -52.9% | 233 | - | $944 | $954,443 | 2 | Central Partnership | false | false |
| 8 | 6 | Drag Me to Hell | $121,404 | -34% | 166 | -18 | $731 | $2,293,806 | 4 | West Video | false | false |
| 9 | 5 | City Island | $116,402 | -52% | 101 | -9 | $1,152 | $429,898 | 2 | Paradise Group | false | false |
| 10 | 7 | Get That Girl | $67,835 | -53.4% | 184 | -4 | $368 | $289,340 | 2 | N/A | false | false |
| 11 | 10 | Paul Blart: Mall Cop | $54,982 | -37.9% | 91 | - | $604 | $196,087 | 2 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | false | false |
| 12 | - | Oxygen | $48,721 | - | 50 | - | $974 | $48,721 | 1 | N/A | true | false |
| 13 | 9 | Broken Embraces | $25,013 | -79% | 28 | -18 | $893 | $984,737 | 4 | Paradise Group | false | false |
| 14 | 13 | The Proposal | $24,256 | -39.4% | 28 | -21 | $866 | $7,536,378 | 7 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | false | false |
| 15 | 8 | Sex Drive | $23,855 | -81.3% | 65 | -103 | $367 | $626,748 | 3 | Central Partnership | false | false |
| 16 | 12 | Fighting | $23,829 | -42% | 80 | -4 | $297 | $567,890 | 4 | Universal Pictures International (UPI) | false | false |
| 17 | - | Antichrist | $17,037 | - | 7 | - | $2,433 | $254,587 | - | CP Classics | - | false |
| 18 | - | Lyubov.ru | $16,948 | - | 50 | - | $338 | $16,948 | 1 | N/A | true | false |
| 19 | - | The Hangover | $15,771 | - | 23 | - | $685 | $5,209,415 | 1 | Karo Premiere | true | false |
| 20 | 11 | Transformers: Revenge of the Fallen | $11,754 | -72.4% | 60 | -46 | $195 | $18,360,396 | 6 | Central Partnership | false | false |
| 21 | 14 | Labor Pains | $8,599 | -64.5% | 47 | -17 | $182 | $671,966 | 4 | Cascade Film | false | false |
| 22 | - | Pete on the Way to Heaven | $6,815 | - | 5 | - | $1,363 | $6,815 | 1 | N/A | true | false |
| 23 | - | 9 1/2 Dates 2009 Re-release | $6,276 | - | 2 | - | $3,138 | $6,276 | 1 | N/A | true | false |
| 24 | 17 | Paris 36 | $6,227 | -50.3% | 13 | - | $479 | $26,156 | 12 | Volga | false | false |
| 25 | - | Splinter | $3,797 | - | 15 | - | $253 | $58,311 | 4 | - | false | false |
| 26 | 22 | Country Wedding | $3,352 | -3.6% | 2 | - | $1,676 | $8,503 | 2 | Russian Report | false | false |
| 27 | 21 | My Bloody Valentine | $2,563 | -37.2% | 3 | +2 | $854 | $2,091,837 | 17 | Central Partnership | false | false |
| 28 | 20 | Up | $2,548 | -42.2% | 12 | -2 | $212 | $12,109,867 | 10 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | false | false |
| 29 | 18 | Push | $1,970 | -63.9% | 11 | -12 | $179 | $642,295 | 7 | West Video | false | false |
| 30 | 19 | State of Play | $1,494 | -70.7% | 8 | -10 | $186 | $432,249 | 10 | Universal Pictures International (UPI) | false | false |
| 31 | 26 | Departures | $1,104 | -49.1% | 2 | - | $552 | $18,804 | 4 | Russian Report | false | false |
| 32 | 24 | Terminator Salvation | $785 | -68.5% | 8 | -4 | $98 | $14,534,418 | 9 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | false | false |
| 33 | - | The Secret of Moonacre | $587 | - | 10 | - | $58 | $373,270 | 8 | - | false | false |
| 34 | - | Palermo Shooting | $528 | - | 1 | - | $528 | $23,419 | 7 | N/A | false | false |
| 35 | 31 | Three Monkeys | $496 | +31.6% | 2 | - | $248 | $20,738 | 9 | N/A | false | false |
| 36 | 25 | The Haunting in Connecticut | $490 | -80.1% | 4 | -3 | $122 | $530,989 | 9 | N/A | false | false |
| 37 | 28 | Waltz with Bashir | $354 | -37.1% | 2 | - | $177 | $16,773 | 7 | Cinema Without Frontiers | false | false |
| 38 | 29 | Zift | $255 | -52.6% | 1 | -1 | $255 | $25,326 | 11 | Cinema Without Frontiers | false | false |
| 39 | 33 | Krabat and the Legend of the Satanic Mill | $214 | +48.6% | 1 | - | $214 | $186,069 | 10 | Volga | false | false |
| 40 | 30 | Wholetrain 2009 Re-release | $205 | -56.5% | 3 | - | $68 | $15,970 | 6 | - | false | false |
