| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | G-Force | $32,152,000 | $31,706,934 | -$445,066 | -1.4% | 3,697 | $32,185,000 | $31,706,934 | 1 | Walt Disney Studios Motion Pictures | - |
| 2 | 2 | - | Harry Potter and the Half-Blood Prince | $30,000,000 | $29,462,187 | -$537,813 | -1.8% | 4,325 | $221,834,000 | $221,295,818 | 2 | Warner Bros. | - |
| 3 | 3 | - | The Ugly Truth | $27,000,000 | $27,605,576 | +$605,576 | +2.2% | 2,882 | $27,000,000 | $27,605,576 | 1 | Sony Pictures Releasing | - |
| 4 | 4 | - | Orphan | $12,770,000 | $12,871,483 | +$101,483 | +0.8% | 2,750 | $12,770,000 | $12,871,483 | 1 | Warner Bros. | - |
| 5 | 5 | - | Ice Age: Dawn of the Dinosaurs | $8,200,000 | $8,408,430 | +$208,430 | +2.5% | 3,300 | $171,291,000 | $171,499,101 | 4 | Twentieth Century Fox | - |
| 6 | 6 | - | Transformers: Revenge of the Fallen | $8,000,000 | $8,124,427 | +$124,427 | +1.6% | 3,237 | $379,090,000 | $379,214,172 | 5 | DreamWorks | - |
| 7 | 7 | - | The Hangover | $6,465,000 | $6,461,370 | -$3,630 | <0.1% | 2,285 | $247,077,000 | $247,073,766 | 8 | Warner Bros. | - |
| 8 | 8 | - | The Proposal | $6,423,000 | $6,379,926 | -$43,074 | -0.7% | 2,779 | $140,086,000 | $140,042,989 | 6 | Walt Disney Studios Motion Pictures | - |
| 9 | 9 | - | Public Enemies | $4,170,000 | $4,352,650 | +$182,650 | +4.4% | 2,291 | $88,096,000 | $88,278,880 | 4 | Universal Pictures | - |
| 10 | 10 | - | Brüno | $2,719,000 | $2,832,870 | +$113,870 | +4.2% | 1,895 | $56,516,000 | $56,629,390 | 3 | Universal Pictures | - |
| 11 | 12 | +1 | 500 Days of Summer | $1,630,000 | $1,635,772 | +$5,772 | +0.4% | 85 | $3,004,000 | $3,009,526 | 2 | Fox Searchlight Pictures | - |
| 12 | 11 | -1 | Up | $1,609,000 | $1,687,307 | +$78,307 | +4.9% | 1,070 | $283,612,000 | $283,690,231 | 9 | Walt Disney Studios Motion Pictures | - |
| 13 | 13 | - | The Hurt Locker | $1,457,000 | $1,438,355 | -$18,645 | -1.3% | 238 | $4,034,000 | $4,015,070 | 5 | Summit Entertainment | - |
| 14 | 14 | - | My Sister's Keeper | $1,285,000 | $1,341,466 | +$56,466 | +4.4% | 1,258 | $45,026,000 | $45,082,015 | 5 | Warner Bros. | - |
| 15 | 15 | - | I Love You, Beth Cooper | $735,000 | $719,468 | -$15,532 | -2.1% | 730 | $13,393,000 | $13,377,333 | 3 | Twentieth Century Fox | - |
| 16 | 16 | - | Night at the Museum: Battle of the Smithsonian | $635,000 | $649,994 | +$14,994 | +2.4% | 396 | $173,003,000 | $173,018,239 | 10 | Twentieth Century Fox | - |
| 17 | 18 | +1 | Star Trek | $425,000 | $439,445 | +$14,445 | +3.4% | 307 | $254,006,000 | $254,020,378 | 12 | Paramount Pictures | - |
| 18 | 19 | +1 | Moon | $406,000 | $391,260 | -$14,740 | -3.6% | 201 | $3,385,000 | $3,370,366 | 7 | Sony Pictures Classics | - |
| 19 | 21 | +2 | Whatever Works | $316,000 | $303,948 | -$12,052 | -3.8% | 176 | $4,136,000 | $4,440,243 | 6 | Sony Pictures Classics | - |
| 20 | 25 | +5 | Away We Go | $284,000 | $286,525 | +$2,525 | +0.9% | 206 | $8,867,000 | $8,865,132 | 8 | Focus Features | - |
| 21 | 27 | +6 | In the Loop | $201,000 | $191,866 | -$9,134 | -4.5% | 8 | $201,000 | $191,866 | 1 | IFC Films | - |
| 22 | 26 | +4 | Land of the Lost | $190,000 | $191,970 | +$1,970 | +1% | 243 | $48,969,000 | $48,971,155 | 8 | Universal Pictures | - |
| 23 | 28 | +5 | Chéri | $185,000 | $184,760 | -$240 | -0.1% | 188 | $2,347,000 | $2,346,767 | 5 | Miramax | - |
| 24 | 29 | +5 | Imagine That | $165,000 | $175,139 | +$10,139 | +6.1% | 221 | $15,528,000 | $15,537,936 | 7 | Paramount Pictures | - |
| 25 | 33 | +8 | Monsters vs. Aliens | $127,000 | $134,194 | +$7,194 | +5.7% | 210 | $197,770,000 | $197,777,362 | 18 | DreamWorks | - |
| 26 | 35 | +9 | Drag Me to Hell | $119,000 | $111,020 | -$7,980 | -6.7% | 150 | $41,913,000 | $41,905,070 | 9 | Universal Pictures | - |
| 27 | 43 | +16 | The Stoning of Soraya M. | $42,800 | $46,862 | +$4,062 | +9.5% | 30 | $514,000 | $519,730 | 5 | Roadside Attractions | - |
| 28 | 50 | +22 | Easy Virtue | $36,000 | $29,387 | -$6,613 | -18.4% | 34 | $2,544,000 | $2,537,150 | 10 | Sony Pictures Classics | - |
| 29 | 49 | +20 | The Brothers Bloom | $30,000 | $31,564 | +$1,564 | +5.2% | 49 | $3,478,000 | $3,479,844 | 11 | Summit Entertainment | - |
| 30 | 51 | +21 | Every Little Step | $27,000 | $28,045 | +$1,045 | +3.9% | 30 | $1,613,000 | $1,614,134 | 15 | Sony Pictures Classics | - |
| 31 | 54 | +23 | Tetro | $20,300 | $20,811 | +$511 | +2.5% | 16 | $346,000 | $346,359 | 7 | American Zoetrope | - |
| 32 | 59 | +27 | Shrink | $17,000 | $16,443 | -$557 | -3.3% | 2 | $17,000 | $16,443 | 1 | Roadside Attractions | - |
| 33 | 58 | +25 | Unmistaken Child | $15,200 | $17,381 | +$2,181 | +14.3% | 6 | $155,000 | $157,507 | 8 | Oscilloscope | - |
| 34 | 62 | +28 | Soul Power | $13,000 | $13,004 | +$4 | <0.1% | 7 | $82,000 | $81,963 | 3 | Sony Pictures Classics | - |
| 35 | 63 | +28 | The Answer Man | $13,000 | $12,998 | -$2 | <0.1% | 6 | $13,000 | $12,998 | 1 | Magnolia Pictures | - |
| 36 | 65 | +29 | War Eagle, Arkansas | $11,700 | $11,715 | +$15 | +0.1% | 2 | $74,300 | $74,280 | 7 | Hannover House | - |
| 37 | 71 | +34 | Herb & Dorothy | $3,620 | $8,117 | +$4,497 | +124.2% | 6 | $129,000 | $133,592 | 8 | Arthouse Films | - |
| 38 | 92 | +54 | Treeless Mountain | $1,550 | $1,560 | +$10 | +0.6% | 1 | $56,600 | $56,602 | 14 | Oscilloscope | - |
