| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $8,501,995 | -73.7% | 586 | +2 | $14,508 | $54,310,458 | 2 | Warner Bros. | false | false |
| 2 | - | The Proposal | $5,336,815 | - | 428 | - | $12,469 | $5,336,815 | - | Walt Disney Pictures | - | false |
| 3 | 2 | Ice Age: Dawn of the Dinosaurs | $3,532,954 | -24.1% | 507 | +4 | $6,968 | $41,480,322 | 4 | 20th Century Fox International | false | false |
| 4 | 3 | Brüno | $1,991,495 | -47% | 445 | -12 | $4,475 | $21,601,920 | 3 | Universal Pictures International (UPI) | false | false |
| 5 | - | The Hangover | $1,129,513 | - | 354 | - | $3,190 | $32,000,378 | - | Warner Bros. | - | false |
| 6 | 5 | Transformers: Revenge of the Fallen | $684,139 | -38.3% | 360 | -45 | $1,900 | $42,511,076 | 6 | Paramount Pictures International | false | false |
| 7 | 6 | Public Enemies | $455,491 | -40.7% | 277 | -83 | $1,644 | $10,434,215 | 4 | Universal Pictures International (UPI) | false | false |
| 8 | 7 | My Sister's Keeper | $368,396 | -40.4% | 283 | -28 | $1,301 | $9,200,373 | 5 | Entertainment Film Distributors | false | false |
| 9 | 8 | Moon | $226,574 | -12.1% | 59 | +2 | $3,840 | $737,117 | 2 | Warner Bros. | false | false |
| 10 | - | Antichrist | $162,737 | - | 38 | - | $4,282 | $162,737 | 1 | Artificial Eye | true | false |
| 11 | - | Luck | $142,279 | - | 35 | - | $4,065 | $142,279 | 1 | Studio 18 | true | false |
| 12 | 10 | Night at the Museum: Battle of the Smithsonian | $58,771 | -27.4% | 138 | -65 | $425 | $32,289,043 | 10 | 20th Century Fox International | false | false |
| 13 | - | Race to Witch Mountain | $54,143 | - | 161 | - | $336 | $4,180,119 | 16 | Walt Disney Pictures | false | false |
| 14 | 13 | 35 Shots of Rum | $33,325 | -33.1% | 19 | -1 | $1,753 | $205,599 | 3 | New Wave Films | false | false |
| 15 | 11 | Kambakkht Ishq | $31,804 | -42% | 23 | -2 | $1,382 | $1,118,612 | 4 | Eros Worldwide | false | false |
| 16 | 14 | The Private Lives of Pippa Lee | $24,409 | -47.7% | 19 | -7 | $1,284 | $239,825 | 3 | Icon Film Distribution | false | false |
| 17 | 9 | Year One | $24,278 | -72% | 68 | -100 | $357 | $4,661,861 | 6 | Sony Pictures Releasing | false | false |
| 18 | 17 | Frozen River | $23,944 | -21.1% | 8 | +1 | $2,993 | $79,780 | 2 | Axiom Films | false | false |
| 19 | 24 | Hannah Montana: The Movie | $13,984 | -2.2% | 42 | -4 | $332 | $13,765,312 | 13 | Walt Disney Pictures | false | false |
| 20 | 18 | Terminator Salvation | $13,606 | -53.7% | 22 | -25 | $618 | $23,292,457 | 8 | Sony Pictures Releasing | false | false |
| 21 | 20 | Looking for Eric | $12,961 | -35.3% | 14 | -4 | $925 | $2,043,575 | 7 | Entertainment Film Distributors | false | false |
| 22 | 25 | Star Trek | $12,923 | +8.5% | 12 | -2 | $1,076 | $34,809,821 | 12 | Paramount Pictures International | false | false |
| 23 | 15 | Shortkut - The Con Is On | $11,271 | -71.1% | 8 | -15 | $1,408 | $273,477 | 3 | Studio 18 | false | false |
| 24 | 23 | Sunshine Cleaning | $8,893 | -42.5% | 7 | -1 | $1,270 | $625,445 | 5 | N/A | false | false |
| 25 | 19 | New York | $7,738 | -70.5% | 7 | -19 | $1,105 | $649,485 | 5 | Yash Raj Films | false | false |
| 26 | 21 | Angels & Demons | $7,694 | -61.1% | 5 | -3 | $1,538 | $30,477,031 | 11 | Sony Pictures Releasing | false | false |
| 27 | - | Skin | $7,008 | - | 2 | - | $3,504 | $7,008 | 1 | ICA Films | true | false |
| 28 | - | Once Upon a Time in the West 2009 Re-release | $6,925 | - | 2 | - | $3,462 | $6,925 | 1 | British Film Institute (BFI) | true | false |
| 29 | - | Modhi Vilayadu | $6,653 | - | 2 | - | $3,326 | $6,653 | 1 | Ayngaran International | true | false |
| 30 | 29 | Katyn | $6,487 | -23.8% | 6 | - | $1,081 | $207,807 | 6 | Artificial Eye | false | false |
| 31 | 26 | Rudo y Cursi | $5,707 | -45.1% | 6 | -2 | $951 | $248,639 | 5 | Optimum Releasing | false | false |
| 32 | 31 | Drag Me to Hell | $5,231 | -28.3% | 3 | -5 | $1,743 | $10,424,087 | 9 | Lionsgate Films | false | false |
| 33 | 16 | Monsters vs. Aliens | $5,150 | -85.5% | 28 | -63 | $183 | $34,697,647 | 17 | Paramount Pictures International | false | false |
| 34 | - | Just Another Love Story | $5,116 | - | 4 | - | $1,279 | $5,116 | 1 | Revolver Entertainment | true | false |
| 35 | 33 | Coraline | $5,081 | +7.9% | 25 | -2 | $203 | $11,985,711 | 12 | Universal Pictures International (UPI) | false | false |
| 36 | 30 | Last Chance Harvey | $4,981 | -36.2% | 3 | -2 | $1,660 | $3,322,900 | 8 | Momentum Pictures | false | false |
| 37 | 27 | The Informers | $4,835 | -51.8% | 4 | - | $1,208 | $23,693 | 2 | N/A | false | false |
| 38 | - | Charles Dickens's England | $4,454 | - | 2 | - | $2,227 | $4,454 | 1 | Guerilla Films | true | false |
| 39 | 22 | Fired Up! | $3,634 | -81.2% | 22 | -34 | $165 | $139,720 | 3 | Sony Pictures Releasing | false | false |
| 40 | - | Pierrot the Fool 2009 Re-release | $3,378 | - | 4 | - | $844 | $47,138 | 10 | British Film Institute (BFI) | false | false |
| 41 | 32 | Kisses | $3,153 | -51.7% | 6 | - | $525 | $15,009 | 36 | Element Films | false | false |
| 42 | 36 | Cloud 9 | $2,416 | -14.3% | 3 | - | $805 | $19,875 | 3 | Soda Pictures | false | false |
| 43 | 34 | Blood: The Last Vampire | $2,376 | -32.4% | 4 | -3 | $594 | $830,098 | 7 | Warner Bros. | false | false |
| 44 | 12 | Burma VJ: Reporting from a Closed Country | $1,923 | -96.3% | 3 | -3 | $641 | $62,502 | 2 | Periscoop Film | false | false |
| 45 | 44 | Anything for Her | $1,795 | +31.3% | 3 | - | $598 | $445,430 | 8 | - | false | false |
| 46 | 49 | Telstar: The Joe Meek Story | $1,744 | +133.8% | 3 | -1 | $581 | $100,969 | 6 | N/A | false | false |
| 47 | 35 | Synecdoche, New York | $1,570 | -54.6% | 1 | -3 | $1,570 | $864,413 | 11 | Revolver Entertainment | false | false |
| 48 | 37 | The Last House on the Left | $1,452 | -39% | 2 | -2 | $726 | $1,857,946 | 7 | Universal Pictures International (UPI) | false | false |
| 49 | 40 | Soul Power | $1,440 | -23.8% | 2 | - | $720 | $14,314 | 3 | Eureka Entertainment | false | false |
| 50 | 48 | State of Play | $862 | +14.5% | 2 | +1 | $431 | $9,206,492 | 14 | Universal Pictures International (UPI) | false | false |
| 51 | 45 | In the Loop | $749 | -36.2% | 1 | -1 | $749 | $3,518,155 | 15 | Optimum Releasing | false | false |
| 52 | - | Shadows in the Sun | $489 | - | 1 | - | $489 | $16,016 | 8 | Artificial Eye | false | false |
| 53 | 41 | Sleep Furiously | $289 | -83.1% | 1 | -5 | $289 | $121,187 | 9 | New Wave Films | false | false |
| 54 | 46 | The End of the Line | $33 | -96.9% | 1 | -3 | $33 | $85,362 | 7 | Periscoop Film | false | false |
| 55 | 54 | The Young Victoria | $28 | -92.2% | 1 | - | $28 | $8,132,263 | 21 | Momentum Pictures | false | false |
