| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Harry Potter and the Half-Blood Prince | $79,475,000 | $77,835,727 | -$1,639,273 | -2.1% | 4,325 | $159,662,000 | $158,022,354 | 1 | Warner Bros. | - |
| 2 | 2 | - | Ice Age: Dawn of the Dinosaurs | $17,700,000 | $17,561,406 | -$138,594 | -0.8% | 3,817 | $152,005,000 | $151,865,987 | 3 | Twentieth Century Fox | - |
| 3 | 3 | - | Transformers: Revenge of the Fallen | $13,750,000 | $13,691,487 | -$58,513 | -0.4% | 3,857 | $363,867,000 | $363,808,123 | 4 | DreamWorks | - |
| 4 | 4 | - | Brüno | $8,374,000 | $8,318,385 | -$55,615 | -0.7% | 2,759 | $49,588,000 | $49,533,475 | 2 | Universal Pictures | - |
| 5 | 6 | +1 | The Hangover | $8,315,000 | $8,177,272 | -$137,728 | -1.7% | 2,667 | $235,882,000 | $235,744,423 | 7 | Warner Bros. | - |
| 6 | 5 | -1 | The Proposal | $8,294,000 | $8,289,707 | -$4,293 | <0.1% | 3,043 | $128,087,000 | $128,083,273 | 5 | Walt Disney Studios Motion Pictures | - |
| 7 | 7 | - | Public Enemies | $7,592,000 | $7,748,235 | +$156,235 | +2.1% | 3,118 | $79,483,000 | $79,639,205 | 3 | Universal Pictures | - |
| 8 | 8 | - | Up | $3,147,000 | $3,172,014 | +$25,014 | +0.8% | 1,706 | $279,559,000 | $279,583,282 | 8 | Walt Disney Studios Motion Pictures | - |
| 9 | 9 | - | My Sister's Keeper | $2,825,000 | $2,828,367 | +$3,367 | +0.1% | 1,967 | $41,504,000 | $41,507,695 | 4 | Warner Bros. | - |
| 10 | 10 | - | I Love You, Beth Cooper | $2,665,000 | $2,766,863 | +$101,863 | +3.8% | 1,872 | $10,261,000 | $10,363,239 | 2 | Twentieth Century Fox | - |
| 11 | 11 | - | The Taking of Pelham 123 | $885,000 | $889,259 | +$4,259 | +0.5% | 610 | $62,896,000 | $62,900,310 | 6 | Sony Pictures Releasing | - |
| 12 | 12 | - | 500 Days of Summer | $838,000 | $834,501 | -$3,499 | -0.4% | 27 | $838,000 | $834,501 | 1 | Fox Searchlight Pictures | - |
| 13 | 14 | +1 | The Hurt Locker | $764,000 | $740,224 | -$23,776 | -3.1% | 94 | $2,172,000 | $2,148,619 | 4 | Summit Entertainment | - |
| 14 | 13 | -1 | Night at the Museum: Battle of the Smithsonian | $760,000 | $759,571 | -$429 | <0.1% | 515 | $171,821,000 | $171,820,365 | 9 | Twentieth Century Fox | - |
| 15 | 15 | - | Star Trek | $677,000 | $690,639 | +$13,639 | +2% | 505 | $253,151,000 | $253,164,613 | 11 | Paramount Pictures | - |
| 16 | 16 | - | Moon | $538,000 | $525,740 | -$12,260 | -2.3% | 251 | $2,666,000 | $2,654,338 | 6 | Sony Pictures Classics | - |
| 17 | 18 | +1 | Whatever Works | $517,000 | $471,288 | -$45,712 | -8.8% | 228 | $3,937,000 | $3,890,755 | 5 | Sony Pictures Classics | - |
| 18 | 17 | -1 | Away We Go | $498,000 | $496,917 | -$1,083 | -0.2% | 299 | $8,285,000 | $8,283,525 | 7 | Focus Features | - |
| 19 | 24 | +5 | Chéri | $294,000 | $275,822 | -$18,178 | -6.2% | 191 | $2,025,000 | $2,006,919 | 4 | Miramax | - |
| 20 | 26 | +6 | Land of the Lost | $223,000 | $240,300 | +$17,300 | +7.8% | 267 | $48,591,000 | $48,608,305 | 7 | Universal Pictures | - |
| 21 | 28 | +7 | X-Men Origins: Wolverine | $190,000 | $192,096 | +$2,096 | +1.1% | 226 | $179,191,000 | $179,193,521 | 12 | Twentieth Century Fox | - |
| 22 | 29 | +7 | Monsters vs. Aliens | $183,000 | $185,191 | +$2,191 | +1.2% | 230 | $197,481,000 | $197,482,447 | 17 | DreamWorks | - |
| 23 | 30 | +7 | Drag Me to Hell | $138,000 | $150,705 | +$12,705 | +9.2% | 192 | $41,691,000 | $41,703,805 | 8 | Universal Pictures | - |
| 24 | 31 | +7 | Imagine That | $108,000 | $114,198 | +$6,198 | +5.7% | 144 | $15,300,000 | $15,305,582 | 6 | Paramount Pictures | - |
| 25 | 32 | +7 | Dance Flick | $84,000 | $85,271 | +$1,271 | +1.5% | 113 | $25,615,000 | $25,615,792 | 9 | Paramount Pictures | - |
| 26 | 34 | +8 | The Stoning of Soraya M. | $77,900 | $73,582 | -$4,318 | -5.5% | 34 | $440,000 | $435,505 | 4 | Roadside Attractions | - |
| 27 | 39 | +12 | Easy Virtue | $62,700 | $47,656 | -$15,044 | -24% | 48 | $2,489,000 | $2,473,685 | 9 | Sony Pictures Classics | - |
| 28 | 47 | +19 | The Brothers Bloom | $47,000 | $34,250 | -$12,750 | -27.1% | 68 | $3,439,000 | $3,426,422 | 10 | Summit Entertainment | - |
| 29 | 51 | +22 | Tetro | $31,500 | $28,201 | -$3,299 | -10.5% | 16 | $306,000 | $312,827 | 6 | American Zoetrope | - |
| 30 | 55 | +25 | Soul Power | $21,000 | $19,927 | -$1,073 | -5.1% | 9 | $57,000 | $55,944 | 2 | Sony Pictures Classics | - |
| 31 | 50 | +19 | Every Little Step | $18,700 | $29,194 | +$10,494 | +56.1% | 35 | $1,559,000 | $1,569,549 | 14 | Sony Pictures Classics | - |
| 32 | 62 | +30 | Death in Love | $16,000 | $14,296 | -$1,704 | -10.6% | 4 | $16,000 | $14,296 | 1 | Screen Media Films | - |
| 33 | 64 | +31 | War Eagle, Arkansas | $13,900 | $13,812 | -$88 | -0.6% | 2 | $60,300 | $60,260 | 6 | Hannover House | - |
