| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Ice Age: Dawn of the Dinosaurs | $106,498 | -25.8% | 21 | - | $5,071 | $836,552 | 3 | 20th Century Fox International | false | false |
| 2 | - | Harry Potter and the Half-Blood Prince | $73,965 | - | 10 | - | $7,396 | $109,757 | 1 | Warner Bros. | true | false |
| 3 | 2 | Brüno | $51,125 | -45.1% | 10 | - | $5,112 | $211,632 | 2 | N/A | false | false |
| 4 | 3 | The Hangover | $13,794 | +2.4% | 6 | - | $2,299 | $268,658 | 6 | Warner Bros. | false | false |
| 5 | 5 | Drag Me to Hell | $4,699 | -0.5% | 4 | - | $1,174 | $48,565 | 4 | Walt Disney Pictures | false | false |
| 6 | 4 | Transformers: Revenge of the Fallen | $4,469 | -12.5% | 5 | - | $893 | $89,862 | 4 | United International Pictures | false | false |
| 7 | 6 | Angels & Demons | $2,867 | -23.8% | 2 | - | $1,433 | $449,546 | 10 | Sony Pictures Releasing | false | false |
| 8 | 7 | Hannah Montana: The Movie | $2,230 | -23.2% | 8 | - | $278 | $91,298 | 5 | Walt Disney Pictures | false | false |
| 9 | 10 | Knowing | $1,001 | -23.9% | 3 | - | $333 | $21,764 | 5 | N/A | false | false |
| 10 | 8 | Fighting | $899 | -52.9% | 6 | - | $149 | $40,705 | 5 | United International Pictures | false | false |
| 11 | 11 | The Boat That Rocked | $757 | +2.7% | 9 | - | $84 | $34,647 | 6 | United International Pictures | false | false |
| 12 | 9 | Terminator Salvation | $656 | -63% | 2 | -4 | $328 | $144,205 | 7 | Sony Pictures Releasing | false | false |
