| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Harry Potter and the Half-Blood Prince | $3,568,946 | - | 215 | - | $16,599 | $4,910,630 | 1 | Warner Bros. | true | false |
| 2 | 1 | Ice Age: Dawn of the Dinosaurs | $1,323,944 | -34.7% | 241 | - | $5,493 | $6,897,919 | 3 | 20th Century Fox International | false | false |
| 3 | 2 | Brüno | $496,408 | -47.7% | 94 | +1 | $5,280 | $1,794,013 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | 5 | Het geheim van Mega Mindy | $275,292 | -25.2% | 107 | - | $2,572 | $935,617 | 2 | Independent Films | false | false |
| 5 | 4 | The Proposal | $258,327 | -33.6% | 83 | -1 | $3,112 | $2,646,363 | 5 | Walt Disney Pictures | false | false |
| 6 | 6 | The Hangover | $250,550 | -25.8% | 66 | -1 | $3,796 | $3,433,929 | 6 | Warner Bros. | false | false |
| 7 | 3 | Transformers: Revenge of the Fallen | $177,026 | -57.8% | 88 | -20 | $2,011 | $3,327,186 | 4 | Universal Pictures International (UPI) | false | false |
| 8 | 7 | Angels & Demons | $81,935 | -45.9% | 47 | -26 | $1,743 | $7,639,610 | 10 | Sony Pictures Releasing | false | false |
| 9 | 8 | Drag Me to Hell | $79,201 | -42% | 28 | -12 | $2,828 | $527,805 | 3 | RCV Film Distribution | false | false |
| 10 | 9 | Coco Before Chanel | $35,468 | -23.4% | 29 | +2 | $1,223 | $848,544 | 8 | RCV Film Distribution | false | false |
| 11 | 13 | A Summer in Genoa | $19,600 | -22.3% | 7 | - | $2,800 | $59,304 | 2 | A-Film Distribution | false | false |
| 12 | - | In the Electric Mist | $18,120 | - | 11 | - | $1,647 | $21,997 | 1 | Benelux Film Distributors | true | false |
| 13 | - | 35 Shots of Rum | $15,775 | - | 6 | - | $2,629 | $21,071 | 1 | Cinéart | true | false |
| 14 | 15 | Beverly Hills Chihuahua | $15,317 | -27.8% | 32 | -19 | $478 | $1,019,753 | 13 | Walt Disney Pictures | false | false |
| 15 | 11 | State of Play | $15,130 | -50.7% | 8 | -14 | $1,891 | $363,448 | 5 | Universal Pictures International (UPI) | false | false |
| 16 | 12 | Disgrace | $14,416 | -43.9% | 9 | -2 | $1,601 | $229,549 | 7 | A-Film Distribution | false | false |
| 17 | 14 | The Reader | $14,309 | -39% | 18 | -1 | $794 | $1,965,429 | 16 | Benelux Film Distributors | false | false |
| 18 | - | Rudo y Cursi | $12,498 | - | 12 | - | $1,041 | $19,687 | 1 | A-Film Distribution | true | false |
| 19 | 10 | Night at the Museum: Battle of the Smithsonian | $11,147 | -66.9% | 20 | -27 | $557 | $2,317,341 | 9 | Warner Bros. | false | false |
| 20 | 16 | Management | $10,220 | -51.8% | 8 | - | $1,277 | $55,660 | 2 | RCV Film Distribution | false | false |
