| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Brüno | $8,103,574 | - | 456 | - | $17,770 | $8,103,574 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | Ice Age: Dawn of the Dinosaurs | $7,699,209 | -38.3% | 522 | -4 | $14,749 | $24,992,757 | 2 | 20th Century Fox International | false | false |
| 3 | 3 | Transformers: Revenge of the Fallen | $2,348,765 | -35% | 469 | -22 | $5,008 | $38,214,967 | 4 | Paramount Pictures International | false | false |
| 4 | - | The Hangover | $1,991,634 | - | 402 | - | $4,954 | $26,730,781 | - | Warner Bros. | - | false |
| 5 | 2 | Public Enemies | $1,699,013 | -53.3% | 455 | -3 | $3,734 | $7,470,451 | 2 | Universal Pictures International (UPI) | false | false |
| 6 | 5 | My Sister's Keeper | $1,095,469 | -12% | 351 | -2 | $3,120 | $6,605,466 | 3 | Entertainment Film Distributors | false | false |
| 7 | 6 | Year One | $393,735 | -50.8% | 299 | -81 | $1,316 | $4,274,206 | 4 | Sony Pictures Releasing | false | false |
| 8 | 8 | Night at the Museum: Battle of the Smithsonian | $172,469 | -29.8% | 283 | -204 | $609 | $31,562,656 | 8 | 20th Century Fox International | false | false |
| 9 | 7 | Kambakkht Ishq | $169,923 | -65.3% | 52 | -4 | $3,267 | $893,449 | 2 | Eros Worldwide | false | false |
| 10 | - | Shortkut - The Con Is On | $130,442 | - | 34 | - | $3,836 | $130,442 | 1 | Studio 18 | true | false |
| 11 | 9 | Terminator Salvation | $111,085 | -54.6% | 125 | -107 | $888 | $22,874,674 | 6 | Sony Pictures Releasing | false | false |
| 12 | - | The Private Lives of Pippa Lee | $72,136 | - | 25 | - | $2,885 | $72,136 | 1 | Icon Film Distribution | true | false |
| 13 | - | Fired Up! | $49,739 | - | 82 | - | $606 | $49,739 | 1 | Sony Pictures Releasing | true | false |
| 14 | 12 | Angels & Demons | $45,969 | -46.5% | 35 | -45 | $1,313 | $29,996,694 | 9 | Sony Pictures Releasing | false | false |
| 15 | 14 | Looking for Eric | $43,676 | -14.5% | 55 | -6 | $794 | $1,917,979 | 5 | Entertainment Film Distributors | false | false |
| 16 | - | 35 Shots of Rum | $43,652 | - | 15 | - | $2,910 | $43,652 | 1 | New Wave Films | true | false |
| 17 | 10 | Sunshine Cleaning | $36,152 | -59.1% | 25 | -46 | $1,446 | $555,282 | 3 | N/A | false | false |
| 18 | 13 | New York | $34,259 | -60.1% | 13 | -19 | $2,635 | $572,853 | 3 | Yash Raj Films | false | false |
| 19 | 16 | Hannah Montana: The Movie | $27,830 | -39.3% | 76 | -71 | $366 | $13,528,671 | 11 | Walt Disney Pictures | false | false |
| 20 | 15 | Star Trek | $26,497 | -42.5% | 23 | -32 | $1,152 | $34,296,616 | 10 | Paramount Pictures International | false | false |
| 21 | 18 | Rudo y Cursi | $18,462 | -43.1% | 11 | -17 | $1,678 | $206,709 | 3 | Optimum Releasing | false | false |
| 22 | 11 | Blood: The Last Vampire | $17,026 | -80.5% | 28 | -139 | $608 | $804,207 | 5 | Warner Bros. | false | false |
| 23 | 17 | Drag Me to Hell | $15,662 | -64.3% | 28 | -42 | $559 | $10,261,220 | 7 | Lionsgate Films | false | false |
| 24 | 22 | Last Chance Harvey | $15,647 | +27.3% | 22 | -2 | $711 | $3,235,858 | 6 | Momentum Pictures | false | false |
| 25 | 19 | Katyn | $11,771 | -32.4% | 11 | -4 | $1,070 | $167,882 | 4 | Artificial Eye | false | false |
| 26 | 21 | Coraline | $11,555 | -21.9% | 39 | -24 | $296 | $11,802,888 | 10 | Universal Pictures International (UPI) | false | false |
| 27 | - | Cloud 9 | $5,847 | - | 6 | - | $974 | $5,847 | 1 | Soda Pictures | true | false |
| 28 | 26 | Monsters vs. Aliens | $5,604 | +18.5% | 29 | -8 | $193 | $34,284,662 | 15 | Paramount Pictures International | false | false |
| 29 | 25 | Anything for Her | $4,946 | -23.3% | 7 | -1 | $706 | $428,875 | 6 | - | false | false |
| 30 | 23 | Synecdoche, New York | $4,497 | -37.3% | 4 | -5 | $1,124 | $838,375 | 9 | Revolver Entertainment | false | false |
| 31 | - | Soul Power | $3,689 | - | 6 | - | $614 | $3,689 | 1 | Eureka Entertainment | true | false |
| 32 | 30 | State of Play | $3,238 | -0.4% | 4 | -2 | $809 | $9,081,115 | 12 | Universal Pictures International (UPI) | false | false |
| 33 | 48 | Sleep Furiously | $2,873 | +271.2% | 5 | +1 | $574 | $109,672 | 7 | New Wave Films | false | false |
| 34 | 27 | In the Loop | $2,736 | -33.5% | 3 | -4 | $912 | $3,461,756 | 13 | Optimum Releasing | false | false |
| 35 | 36 | Shirin | $2,481 | +20.8% | 1 | - | $2,481 | $16,986 | 3 | British Film Institute (BFI) | false | false |
| 36 | 37 | Let the Right One In | $2,037 | +2% | 9 | +6 | $226 | $1,827,744 | 14 | Momentum Pictures | false | false |
| 37 | 20 | The Last House on the Left | $2,037 | -88% | 9 | -21 | $226 | $1,827,744 | 5 | Universal Pictures International (UPI) | false | false |
| 38 | 35 | Gigantic | $2,010 | -5.3% | 5 | +1 | $402 | $19,739 | 3 | The Works UK Distribution | false | false |
| 39 | 39 | Sugar | $1,888 | +20.7% | 3 | +2 | $629 | $33,834 | 6 | Axiom Films | false | false |
| 40 | 54 | Chéri | $1,797 | +244.9% | 6 | +3 | $299 | $663,229 | 10 | Warner Bros. | false | false |
| 41 | 34 | Lake Tahoe | $1,744 | -24.5% | 3 | +1 | $581 | $10,750 | 3 | - | false | false |
| 42 | 29 | Telstar: The Joe Meek Story | $1,632 | -50.8% | 4 | +1 | $408 | $91,926 | 4 | N/A | false | false |
| 43 | 31 | A Girl Cut in Two | $1,425 | -48.6% | 4 | +2 | $356 | $113,513 | 8 | Artificial Eye | false | false |
| 44 | - | Vicky Cristina Barcelona | $1,243 | - | 1 | - | $1,243 | $4,330,962 | 23 | Optimum Releasing | false | false |
| 45 | 40 | Fireflies in the Garden 2008 Re-release | $1,104 | -24% | 2 | -5 | $552 | $97,167 | 7 | The Works UK Distribution | false | false |
| 46 | - | Encounters at the End of the World | $1,092 | - | 1 | - | $1,092 | $236,908 | 12 | Revolver Entertainment | false | false |
| 47 | 56 | The End of the Line | $1,018 | +125.7% | 4 | +1 | $254 | $81,051 | 5 | Periscoop Film | false | false |
| 48 | 46 | Fugitive Pieces | $963 | +4.6% | 2 | -2 | $481 | $22,182 | 7 | Soda Pictures | false | false |
| 49 | 43 | Fermat's Room 2009 Re-release | $812 | -31.3% | 1 | - | $812 | $42,691 | 7 | Revolver Entertainment | false | false |
| 50 | - | Mishima: A Life in Four Chapters 2009 Re-release | $548 | - | 1 | - | $548 | $548 | 1 | ICA Films | true | false |
| 51 | 55 | Shadows in the Sun | $370 | -24.6% | 1 | -1 | $370 | $10,721 | 6 | Artificial Eye | false | false |
| 52 | - | Ichi | $285 | - | 1 | - | $285 | $285 | 1 | Manga Entertainment | true | false |
| 53 | - | Awaydays | $235 | - | 1 | - | $235 | $129,261 | 8 | Optimum Releasing | false | false |
| 54 | - | Echoes of Home 2009 Re-release | $175 | - | 1 | - | $175 | $175 | 1 | ICA Films | true | false |
