| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Transformers: Revenge of the Fallen | $721,314 | - | 60 | - | $12,021 | $1,025,206 | 1 | Paramount Pictures International | true | false |
| 2 | 1 | Up | $251,577 | -22.6% | 42 | - | $5,989 | $1,233,177 | 3 | Walt Disney Pictures | false | false |
| 3 | 2 | Knowing | $151,075 | -36.7% | 35 | - | $4,316 | $474,040 | 2 | N/A | false | false |
| 4 | - | Righteous Kill | $68,179 | - | 24 | - | $2,840 | $68,179 | 1 | N/A | true | false |
| 5 | 3 | Terminator Salvation | $32,829 | -59.1% | 34 | -18 | $965 | $977,457 | 4 | Sony Pictures Releasing | false | false |
| 6 | 4 | Motor Y Motivo | $30,171 | -58.4% | 35 | - | $862 | $341,776 | 3 | United International Pictures | false | false |
| 7 | 5 | Duplicity | $24,569 | -48.6% | 23 | - | $1,068 | $91,898 | 2 | Universal Pictures International (UPI) | false | false |
| 8 | 9 | Ghosts of Girlfriends Past | $6,382 | -54.1% | 22 | - | $290 | $306,625 | 7 | Warner Bros. | false | false |
| 9 | 6 | Night at the Museum: Battle of the Smithsonian | $3,307 | -86.1% | 60 | - | $55 | $1,234,546 | 6 | 20th Century Fox International | false | false |
| 10 | 8 | The Unborn | $2,254 | -84.4% | 32 | - | $70 | $492,130 | 5 | Universal Pictures International (UPI) | false | false |
| 11 | 10 | Angels & Demons | $839 | -91.8% | 1 | -8 | $839 | $1,339,785 | 7 | Sony Pictures Releasing | false | false |
| 12 | 12 | Hannah Montana: The Movie | $465 | -88.6% | 26 | - | $17 | $528,485 | 8 | Walt Disney Pictures | false | false |
| 13 | 18 | Sex Drive | $69 | +86.5% | 5 | - | $13 | $78,841 | 4 | N/A | false | false |
