| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Transformers: Revenge of the Fallen | $5,110,423 | - | 908 | - | $5,628 | $8,166,640 | 1 | Paramount Pictures International | true | false |
| 2 | 2 | Up | $1,058,730 | -36.7% | 751 | -34 | $1,409 | $12,482,674 | 4 | Walt Disney Pictures | false | false |
| 3 | 1 | Night at the Museum: Battle of the Smithsonian | $1,018,968 | -45.7% | 455 | -356 | $2,239 | $8,406,190 | 3 | 20th Century Fox International | false | false |
| 4 | 3 | The Proposal | $935,103 | -33.7% | 433 | -3 | $2,159 | $3,286,456 | 2 | Walt Disney Pictures | false | false |
| 5 | - | Ice Age: Dawn of the Dinosaurs | $494,937 | - | 116 | - | $4,266 | $494,937 | - | 20th Century Fox International | - | false |
| 6 | 4 | 17 Again | $409,883 | -35% | 309 | -1 | $1,326 | $1,392,555 | 2 | Gussi Films | false | false |
| 7 | - | My Sister's Keeper | $350,273 | - | 199 | - | $1,760 | $350,273 | 1 | Warner Bros. | true | false |
| 8 | 5 | Angels & Demons | $189,897 | -53.1% | 308 | -140 | $616 | $13,119,817 | 7 | Sony Pictures Releasing | false | false |
| 9 | 6 | X-Men Origins: Wolverine | $133,733 | -66.7% | 280 | -115 | $477 | $10,043,753 | 9 | 20th Century Fox International | false | false |
| 10 | 7 | Star Trek | $108,758 | -71.2% | 225 | -155 | $483 | $3,224,272 | 8 | Paramount Pictures International | false | false |
| 11 | 8 | State of Play | $54,783 | -27.6% | 75 | -15 | $730 | $1,473,037 | 4 | Universal Pictures International (UPI) | false | false |
| 12 | 9 | Hannah Montana: The Movie | $33,416 | -42.2% | 61 | -65 | $547 | $2,369,538 | 6 | Walt Disney Pictures | false | false |
| 13 | 12 | Push | $22,364 | -37.9% | 37 | -15 | $604 | $719,253 | 15 | N/A | false | false |
| 14 | 10 | The Last House on the Left | $22,356 | -57.4% | 46 | -49 | $486 | $393,169 | 6 | Universal Pictures International (UPI) | false | false |
| 15 | - | Happy-Go-Lucky | $20,230 | - | 10 | - | $2,023 | $20,230 | 1 | N/A | true | false |
| 16 | 13 | Ghosts of Girlfriends Past | $16,426 | -41.1% | 28 | -17 | $586 | $2,675,056 | 7 | Warner Bros. | false | false |
| 17 | - | Blame it on Fidel | $10,698 | - | 9 | - | $1,188 | $10,698 | 1 | N/A | true | false |
| 18 | 17 | Sin Nombre | $7,886 | -36.5% | 17 | -21 | $463 | $586,935 | 7 | Universal Pictures International (UPI) | false | false |
| 19 | 11 | Zack and Miri Make a Porno | $7,622 | -84.6% | 19 | -94 | $401 | $341,052 | 4 | Gussi Films | false | false |
| 20 | 26 | Boogeyman 2 | $7,485 | +9,496.2% | 25 | +23 | $299 | $82,216 | 8 | Gussi Films | false | false |
| 21 | 21 | Then She Found Me | $4,771 | +54.5% | 11 | -4 | $433 | $142,621 | 7 | Videocine | false | false |
| 22 | 16 | I'm Gonna Explode | $4,385 | -76.2% | 40 | - | $109 | $36,863 | 111 | Videocine | false | false |
| 23 | 19 | The Band's Visit | $4,035 | +0.7% | 9 | +4 | $448 | $48,503 | 4 | N/A | false | false |
| 24 | 20 | Three Monkeys | $4,016 | +17.8% | 3 | -1 | $1,338 | $18,587 | 3 | N/A | false | false |
| 25 | 25 | Personal Effects | $3,897 | +1,066.8% | 4 | +2 | $974 | $76,913 | 5 | Gussi Films | false | false |
| 26 | 22 | Earth | $1,158 | -39.1% | 11 | -4 | $105 | $937,823 | 7 | Walt Disney Pictures | false | false |
| 27 | 18 | Rachel Getting Married | $1,095 | -77.1% | 4 | -2 | $273 | $140,279 | 15 | Sony Pictures Releasing | false | false |
| 28 | 15 | 3:19 | $1,032 | -95% | 4 | -34 | $258 | $30,275 | 111 | N/A | false | false |
| 29 | 14 | While She Was Out | $292 | -98.9% | 3 | -60 | $97 | $178,981 | 3 | Gussi Films | false | false |
