| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Up | $724,664 | -22.5% | 80 | -2 | $9,058 | $3,897,728 | 3 | Walt Disney Pictures | false | false |
| 2 | 2 | Terminator Salvation | $267,725 | -40.2% | 79 | - | $3,388 | $1,920,595 | 3 | Sony Pictures Releasing | false | false |
| 3 | 4 | The Unborn | $204,040 | -18.2% | 45 | +3 | $4,534 | $685,455 | 2 | United International Pictures | false | false |
| 4 | 3 | Night at the Museum: Battle of the Smithsonian | $194,936 | -29.7% | 58 | -4 | $3,360 | $3,787,861 | 5 | 20th Century Fox International | false | false |
| 5 | - | Duplicity | $128,112 | - | 36 | - | $3,558 | $135,261 | 1 | United International Pictures | true | false |
| 6 | 5 | Angels & Demons | $114,405 | -46.9% | 52 | -15 | $2,200 | $4,097,680 | 6 | Sony Pictures Releasing | false | false |
| 7 | - | War | $61,898 | - | 20 | - | $3,094 | $66,151 | 1 | N/A | true | false |
| 8 | 6 | Knowing | $46,171 | -34% | 20 | -7 | $2,308 | $709,892 | 4 | N/A | false | false |
| 9 | - | In Bruges | $26,792 | - | 10 | - | $2,679 | $26,792 | 1 | N/A | true | false |
| 10 | 9 | Flawless | $19,091 | +17.2% | 9 | +3 | $2,121 | $196,319 | 4 | N/A | false | false |
| 11 | 10 | Race to Witch Mountain | $14,405 | +4.1% | 17 | -2 | $847 | $1,807,781 | 8 | Walt Disney Pictures | false | false |
| 12 | 13 | Solstice | $10,813 | +51.5% | 4 | +1 | $2,703 | $223,244 | 5 | N/A | false | false |
| 13 | 8 | Swing Vote | $10,773 | -40.7% | 8 | +3 | $1,346 | $83,612 | 4 | N/A | false | false |
| 14 | 7 | Traitor | $6,696 | -88% | 6 | -17 | $1,116 | $119,681 | 2 | N/A | false | false |
| 15 | 11 | Paris, I Love You | $6,549 | -33.4% | 2 | - | $3,274 | $130,563 | 6 | N/A | false | false |
| 16 | 14 | The Diving Bell and the Butterfly | $3,626 | -40.2% | 1 | -1 | $3,626 | $68,100 | 5 | N/A | false | false |
| 17 | 12 | The Accidental Husband | $2,248 | -77% | 5 | -1 | $449 | $505,288 | 6 | Walt Disney Pictures | false | false |
| 18 | 15 | Swing con son | $2,031 | -45.6% | 4 | - | $507 | $79,165 | 9 | N/A | false | false |
| 19 | 17 | Coraline | $1,184 | -31.4% | 5 | -2 | $236 | $545,266 | 7 | United International Pictures | false | false |
| 20 | 19 | X-Men Origins: Wolverine | $495 | -20.8% | 3 | +1 | $165 | $2,524,914 | 8 | 20th Century Fox International | false | false |
| 21 | 18 | The Strangers | $56 | -91.3% | 1 | -1 | $56 | $485,189 | 9 | N/A | false | false |
