| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Up | $442,263 | - | 42 | - | $10,530 | $442,263 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Terminator Salvation | $176,599 | -52.3% | 55 | - | $3,210 | $768,502 | 2 | Sony Pictures Releasing | false | false |
| 3 | - | Motor Y Motivo | $151,123 | - | 35 | - | $4,317 | $151,123 | 1 | United International Pictures | true | false |
| 4 | 2 | Night at the Museum: Battle of the Smithsonian | $69,771 | -55.1% | 60 | - | $1,162 | $1,185,163 | 4 | 20th Century Fox International | false | false |
| 5 | - | Transporter 3 | $59,916 | - | 23 | - | $2,605 | $59,916 | 1 | N/A | true | false |
| 6 | 3 | The Unborn | $49,188 | -50.6% | 32 | - | $1,537 | $451,736 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | 4 | Angels & Demons | $25,737 | -58.9% | 26 | -16 | $989 | $1,315,610 | 5 | Sony Pictures Releasing | false | false |
| 8 | 7 | Dan in Real Life | $15,993 | -46.2% | 12 | - | $1,332 | $57,692 | 2 | N/A | false | false |
| 9 | 6 | The Accidental Husband | $12,106 | -64.8% | 24 | - | $504 | $167,510 | 3 | Walt Disney Pictures | false | false |
| 10 | 11 | Ghosts of Girlfriends Past | $8,585 | +4.7% | 22 | - | $390 | $277,705 | 5 | Warner Bros. | false | false |
| 11 | 5 | Sex Drive | $6,741 | -85.5% | 22 | - | $306 | $75,813 | 2 | N/A | false | false |
| 12 | 8 | Hannah Montana: The Movie | $6,530 | -71.6% | 26 | - | $251 | $522,149 | 6 | Walt Disney Pictures | false | false |
| 13 | 10 | Fireflies in the Garden 2008 Re-release | $6,334 | -34.2% | 5 | - | $1,266 | $38,138 | 3 | N/A | false | false |
| 14 | 9 | 17 Again | $3,107 | -77.3% | 20 | - | $155 | $303,754 | 7 | Warner Bros. | false | false |
| 15 | 20 | Funny Games | $35 | -36.4% | 15 | - | $2 | $50,033 | 4 | N/A | false | false |
