| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Proposal | $457,149 | - | 45 | - | $10,158 | $569,036 | 1 | Walt Disney Pictures | true | false |
| 2 | - | The Hangover | $343,604 | - | 45 | - | $7,635 | $491,841 | 1 | Warner Bros. | true | false |
| 3 | 2 | Angels & Demons | $223,064 | -21.3% | 98 | - | $2,276 | $4,003,115 | 6 | Sony Pictures Releasing | false | false |
| 4 | 1 | Terminator Salvation | $197,294 | -32.7% | 77 | - | $2,562 | $1,322,659 | 3 | Sony Pictures Releasing | false | false |
| 5 | 3 | Night at the Museum: Battle of the Smithsonian | $184,733 | -10.4% | 65 | -10 | $2,842 | $2,023,959 | 5 | 20th Century Fox International | false | false |
| 6 | - | State of Play | $154,157 | - | 30 | - | $5,138 | $169,969 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 4 | Coraline | $111,032 | -19.7% | 58 | +3 | $1,914 | $288,988 | 2 | Universal Pictures International (UPI) | false | false |
| 8 | 5 | 17 Again | $51,362 | -31% | 30 | -6 | $1,712 | $1,165,931 | 7 | Kinepolis Film Distribution (KFD) | false | false |
| 9 | 7 | Looking for Eric | $43,093 | -28.6% | 18 | - | $2,394 | $141,680 | 2 | Cinéart | false | false |
| 10 | - | A Town Called Panic | $42,181 | - | 19 | - | $2,220 | $48,847 | 1 | Cinéart | true | false |
| 11 | 6 | The Girl with the Dragon Tattoo | $36,919 | -39.2% | 41 | - | $900 | $516,340 | 5 | Benelux Film Distributors | false | false |
| 12 | 9 | Beverly Hills Chihuahua | $31,166 | -34.8% | 34 | -4 | $916 | $1,313,106 | 12 | Walt Disney Pictures | false | false |
| 13 | 8 | X-Men Origins: Wolverine | $28,822 | -40.7% | 26 | -19 | $1,108 | $2,318,526 | 8 | 20th Century Fox International | false | false |
| 14 | 12 | Monsters vs. Aliens | $25,108 | -20.3% | 36 | -5 | $697 | $1,781,846 | 12 | Universal Pictures International (UPI) | false | false |
| 15 | 11 | My Bloody Valentine | $22,562 | -29.1% | 12 | -1 | $1,880 | $592,636 | 8 | Kinepolis Film Distribution (KFD) | false | false |
| 16 | 10 | He's Just Not That Into You | $19,285 | -50.8% | 12 | -7 | $1,607 | $1,169,793 | 9 | Paradiso Entertainment | false | false |
| 17 | 17 | Mid-August Lunch | $17,095 | <0.1% | 6 | - | $2,849 | $44,993 | 2 | ABC Distribution | false | false |
| 18 | 15 | Knowing | $16,620 | -36.5% | 8 | -3 | $2,077 | $2,693,567 | 12 | Belga Films | false | false |
| 19 | 14 | Sunshine Cleaning | $12,038 | -56.8% | 9 | -1 | $1,337 | $122,331 | 3 | A-Film Distribution | false | false |
| 20 | 13 | Star Trek | $11,917 | -62% | 18 | -21 | $662 | $1,012,513 | 7 | Universal Pictures International (UPI) | false | false |
| 21 | 16 | Sister Smile | $10,195 | -57.1% | 23 | -10 | $443 | $570,664 | 7 | Kinepolis Film Distribution (KFD) | false | false |
| 22 | 18 | The Last House on the Left | $8,734 | -34.6% | 7 | -1 | $1,247 | $392,109 | 9 | Universal Pictures International (UPI) | false | false |
| 23 | 19 | Slumdog Millionaire | $8,101 | -38.7% | 15 | -6 | $540 | $3,791,451 | 23 | Cinéart | false | false |
| 24 | 20 | Fast & Furious | $7,291 | -44.3% | 10 | -7 | $729 | $3,346,019 | 11 | Universal Pictures International (UPI) | false | false |
| 25 | 27 | Bolt | $6,662 | +6.4% | 2 | -2 | $3,331 | $3,284,544 | 19 | Walt Disney Pictures | false | false |
| 26 | 22 | Home | $4,852 | -55.5% | 8 | -1 | $606 | $52,023 | 3 | Belga Films | false | false |
| 27 | 21 | Coco Before Chanel | $4,758 | -56.7% | 18 | -3 | $264 | $640,800 | 9 | Kinepolis Film Distribution (KFD) | false | false |
| 28 | 29 | Incognito | $3,922 | -32.5% | 10 | -2 | $392 | $312,690 | 8 | Alternative Films | false | false |
| 29 | 30 | Hotel for Dogs | $3,778 | -23.1% | 2 | - | $1,889 | $1,301,518 | 18 | Universal Pictures International (UPI) | false | false |
| 30 | 24 | S&M Judge | $3,745 | -55.8% | 7 | -4 | $535 | $1,139,809 | 15 | Kinepolis Film Distribution (KFD) | false | false |
| 31 | 33 | The Boy in the Striped Pajamas | $2,113 | -40.4% | 3 | -3 | $704 | $135,110 | 8 | Walt Disney Pictures | false | false |
| 32 | 23 | Bank Error in Your Favour | $1,793 | -82.4% | 8 | -5 | $224 | $79,646 | 4 | Cinéart | false | false |
| 33 | 38 | Eden Is West | $1,572 | +7.8% | 3 | - | $524 | $13,973 | 4 | Alternative Films | false | false |
| 34 | 41 | Synecdoche, New York | $840 | -7% | 2 | -1 | $420 | $18,371 | 6 | Paradiso Entertainment | false | false |
| 35 | 43 | Twilight | $551 | +197.8% | 1 | - | $551 | $3,577,736 | 30 | Belga Films | false | false |
| 36 | 39 | The Reader | $423 | -62.9% | 9 | - | $47 | $884,059 | 16 | Benelux Film Distributors | false | false |
| 37 | 40 | In the Electric Mist | $314 | -69.9% | 5 | - | $62 | $249,071 | 9 | Benelux Film Distributors | false | false |
| 38 | 35 | Chéri | $154 | -92.5% | 6 | - | $25 | $261,427 | 11 | Benelux Film Distributors | false | false |
