| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Up | $1,046,622 | - | 112 | - | $9,344 | $1,437,463 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Terminator Salvation | $405,113 | -44.9% | 148 | -4 | $2,737 | $1,327,092 | 2 | Sony Pictures Releasing | false | false |
| 3 | 2 | Night at the Museum: Battle of the Smithsonian | $197,559 | -46.8% | 115 | +21 | $1,717 | $2,432,466 | 4 | 20th Century Fox International | false | false |
| 4 | 3 | Angels & Demons | $193,615 | -34.4% | 96 | -41 | $2,016 | $3,035,566 | 5 | Sony Pictures Releasing | false | false |
| 5 | - | State of Play | $160,460 | - | 35 | - | $4,584 | $200,270 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | - | Ghosts of Girlfriends Past | $155,274 | - | 42 | - | $3,697 | $199,433 | 1 | Distribution Company | true | false |
| 7 | - | Felicitas | $145,431 | - | 35 | - | $4,155 | $189,033 | 1 | Pachamama Cine | true | false |
| 8 | 4 | Last Chance Harvey | $103,281 | -27.3% | 22 | - | $4,694 | $300,293 | 2 | Distribution Company | false | false |
| 9 | 5 | The Unborn | $60,149 | -46.2% | 31 | -5 | $1,940 | $634,037 | 4 | Universal Pictures International (UPI) | false | false |
| 10 | 8 | Inspector Bellamy | $30,059 | -50.2% | 13 | -1 | $2,312 | $110,878 | 2 | Alfa Films | false | false |
| 11 | 9 | The Reader | $17,930 | -56.1% | 18 | -10 | $996 | $558,671 | 6 | Pachamama Cine | false | false |
| 12 | 7 | New in Town | $17,448 | -73.1% | 20 | -11 | $872 | $228,685 | 3 | Distribution Company | false | false |
| 13 | - | A Week Alone | $7,924 | - | 5 | - | $1,584 | $10,473 | 1 | Primer Plano Film Group | true | false |
| 14 | - | The Roses of the Desert 2009 Re-release | $6,695 | - | 4 | - | $1,673 | $8,946 | 1 | Primer Plano Film Group | true | false |
| 15 | 12 | Earth | $6,406 | -65.1% | 21 | -5 | $305 | $477,671 | 8 | Walt Disney Pictures | false | false |
| 16 | 14 | Race to Witch Mountain | $5,266 | -60% | 31 | -10 | $169 | $978,066 | 10 | Walt Disney Pictures | false | false |
| 17 | 10 | Adventureland | $3,176 | -84.8% | 2 | -8 | $1,588 | $30,044 | 2 | Walt Disney Pictures | false | false |
| 18 | 13 | Duplicity | $2,959 | -79.3% | 5 | -17 | $591 | $590,346 | 8 | Universal Pictures International (UPI) | false | false |
| 19 | 22 | Jardins en automne 2008 Re-release | $2,404 | -50.6% | 3 | -3 | $801 | $80,839 | 7 | IFA | false | false |
| 20 | 36 | Haroldo Conti, homo viator | $1,531 | +216.3% | 3 | +1 | $510 | $4,125 | 3 | N/A | false | false |
| 21 | 23 | The Artist | $1,329 | -69.3% | 2 | -2 | $664 | $23,635 | 3 | Primer Plano Film Group | false | false |
| 22 | 17 | Fast & Furious | $1,303 | -82.7% | 6 | -24 | $217 | $1,898,305 | 11 | Universal Pictures International (UPI) | false | false |
| 23 | 24 | The Class | $1,024 | -67.3% | 2 | -2 | $512 | $303,596 | 9 | Primer Plano Film Group | false | false |
| 24 | 21 | The Merry Widow | $803 | -84.4% | 2 | -7 | $401 | $152,563 | 9 | Alfa Films | false | false |
| 25 | 27 | Blood Appears | $801 | -50.2% | 1 | -1 | $801 | $25,069 | 5 | N/A | false | false |
| 26 | 11 | X-Men Origins: Wolverine | $777 | -96% | 3 | -24 | $259 | $1,725,070 | 7 | 20th Century Fox International | false | false |
| 27 | 15 | 17 Again | $743 | -93.3% | 3 | -22 | $247 | $422,471 | 6 | Distribution Company | false | false |
| 28 | 19 | Lorna's Silence | $730 | -87.6% | 3 | -5 | $243 | $87,454 | 5 | Distribution Company | false | false |
| 29 | 18 | The Accidental Husband | $674 | -88.6% | 4 | -4 | $168 | $225,274 | 7 | Walt Disney Pictures | false | false |
| 30 | 25 | Esperando la carroza 2: Se acabó la fiesta | $635 | -74.5% | 3 | -5 | $211 | $1,303,430 | 11 | Primer Plano Film Group | false | false |
| 31 | 31 | Dragonball Evolution | $495 | -38.8% | 3 | -4 | $165 | $578,067 | 10 | 20th Century Fox International | false | false |
| 32 | 38 | The Edge of Heaven | $363 | +23.9% | 1 | - | $363 | $155,977 | 13 | Alfa Films | false | false |
| 33 | 34 | Luisa | $356 | -42.8% | 1 | - | $356 | $13,787 | 6 | Primer Plano Film Group | false | false |
| 34 | 16 | Star Trek | $343 | -96.2% | 2 | -19 | $171 | $406,611 | 6 | Paramount Pictures International | false | false |
| 35 | 20 | Monsters vs. Aliens | $341 | -94.2% | 2 | -6 | $170 | $1,595,961 | 11 | Paramount Pictures International | false | false |
| 36 | 30 | Days of May | $210 | -75.4% | 1 | -1 | $210 | $17,291 | 4 | Primer Plano Film Group | false | false |
| 37 | 41 | Slumdog Millionaire | $101 | +34.7% | 1 | - | $101 | $1,543,030 | 18 | Distribution Company | false | false |
| 38 | 39 | Rumba | $80 | -70.9% | 1 | -1 | $80 | $67,944 | 11 | Distribution Company | false | false |
| 39 | 29 | Mundo alas | $76 | -92.4% | 1 | -1 | $76 | $35,429 | 12 | Distribution Company | false | false |
| 40 | 43 | Vicky Cristina Barcelona | $59 | +11.3% | 1 | - | $59 | $772,193 | 19 | Pachamama Cine | false | false |
| 41 | 35 | Knowing | $49 | -90.1% | 1 | -4 | $49 | $1,080,098 | 11 | Alfa Films | false | false |
| 42 | 44 | Gomorrah | $21 | -51.2% | 1 | - | $21 | $254,040 | 14 | Alfa Films | false | false |
