| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Terminator Salvation | $76,485 | - | 10 | - | $7,648 | $76,485 | 1 | Sony Pictures Releasing | true | false |
| 2 | 2 | Angels & Demons | $16,372 | -0.9% | 8 | -1 | $2,046 | $250,857 | 4 | Sony Pictures Releasing | false | false |
| 3 | - | New in Town | $15,402 | - | 5 | - | $3,080 | $15,402 | 1 | ACME | true | false |
| 4 | 1 | Fighting | $14,044 | -29% | 7 | - | $2,006 | $50,859 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | 3 | Ghosts of Girlfriends Past | $11,858 | -13.4% | 7 | - | $1,694 | $42,898 | 2 | - | false | false |
| 6 | 4 | Night at the Museum: Battle of the Smithsonian | $11,247 | -8.6% | 8 | - | $1,405 | $70,657 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | 8 | Monsters vs. Aliens | $4,261 | +44.1% | 5 | -2 | $852 | $207,105 | 10 | Universal Pictures International (UPI) | false | false |
| 8 | 6 | 17 Again | $2,840 | -32.2% | 5 | -1 | $568 | $128,723 | 5 | - | false | false |
| 9 | 5 | Dark Planet: Rebellion | $2,323 | -57.8% | 4 | -1 | $580 | $11,096 | 2 | ACME | false | false |
| 10 | 9 | Coraline | $2,321 | +19.9% | 2 | - | $1,160 | $41,669 | 5 | Universal Pictures International (UPI) | false | false |
| 11 | - | Home | $1,422 | - | 1 | - | $1,422 | $1,422 | 1 | N/A | true | false |
| 12 | 10 | My Bloody Valentine | $1,338 | +22.1% | 3 | +1 | $446 | $120,351 | 7 | ACME | false | false |
| 13 | - | Milk | $1,326 | - | 1 | - | $1,326 | $1,326 | 1 | N/A | true | false |
| 14 | 23 | Race to Witch Mountain | $952 | +1,279.7% | 1 | -1 | $952 | $35,525 | 8 | Universal Pictures International (UPI) | false | false |
| 15 | 7 | The Uninvited | $885 | -72.4% | 2 | -1 | $442 | $18,790 | 3 | Universal Pictures International (UPI) | false | false |
| 16 | 14 | The Tale of Despereaux | $478 | -12.8% | 6 | - | $79 | $278,468 | 24 | Universal Pictures International (UPI) | false | false |
| 17 | 20 | Ice Age: The Meltdown | $431 | +239.4% | 2 | - | $215 | $663,262 | 166 | Universal Pictures International (UPI) | false | false |
| 18 | 11 | Star Trek | $306 | -70.5% | 1 | -1 | $306 | $24,433 | 5 | Universal Pictures International (UPI) | false | false |
| 19 | 18 | Delta | $243 | +35.8% | 1 | - | $243 | $726 | 2 | N/A | false | false |
| 20 | 21 | Ratatouille | $167 | +31.5% | 1 | - | $167 | $617,090 | 95 | Universal Pictures International (UPI) | false | false |
| 21 | 28 | Bolt | $144 | +526.1% | 1 | - | $144 | $327,631 | 15 | Universal Pictures International (UPI) | false | false |
| 22 | 22 | Madagascar: Escape 2 Africa | $142 | +57.8% | 1 | - | $142 | $750,415 | 28 | Universal Pictures International (UPI) | false | false |
| 23 | 24 | WALL·E | $113 | +66.2% | 2 | - | $56 | $448,891 | 47 | Universal Pictures International (UPI) | false | false |
| 24 | 13 | Observe and Report | $91 | -89.3% | 1 | -3 | $91 | $22,141 | 4 | - | false | false |
| 25 | 16 | Fast & Furious | $74 | -77.7% | 1 | -1 | $74 | $374,170 | 10 | Universal Pictures International (UPI) | false | false |
| 26 | 19 | Kung Fu Panda | $67 | -52.1% | 1 | - | $67 | $481,418 | 53 | Universal Pictures International (UPI) | false | false |
| 27 | - | Doubt | $64 | - | 1 | - | $64 | $12,740 | 19 | Universal Pictures International (UPI) | false | false |
| 28 | 27 | Gran Torino | $48 | +65.5% | 1 | - | $48 | $40,164 | 11 | - | false | false |
| 29 | 15 | I Love You, Man | $39 | -92.8% | 2 | -2 | $19 | $36,912 | 7 | Universal Pictures International (UPI) | false | false |
| 30 | 12 | X-Men Origins: Wolverine | $26 | -97.4% | 1 | -7 | $26 | $61,398 | 6 | Universal Pictures International (UPI) | false | false |
| 31 | 26 | Confessions of a Shopaholic | $12 | -69.2% | 1 | - | $12 | $81,170 | 9 | Universal Pictures International (UPI) | false | false |
| 32 | - | Hotel for Dogs | $6 | - | 1 | - | $6 | $49,657 | 12 | Universal Pictures International (UPI) | false | false |
