| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Up | $68,200,000 | $68,108,790 | -$91,210 | -0.1% | 3,766 | $68,200,000 | $68,108,790 | 1 | Walt Disney Studios Motion Pictures | - |
| 2 | 2 | - | Night at the Museum: Battle of the Smithsonian | $25,500,000 | $24,353,868 | -$1,146,132 | -4.5% | 4,101 | $105,296,000 | $104,150,268 | 2 | Twentieth Century Fox | - |
| 3 | 4 | +1 | Drag Me to Hell | $16,628,000 | $15,825,480 | -$802,520 | -4.8% | 2,508 | $16,628,000 | $15,825,480 | 1 | Universal Pictures | - |
| 4 | 3 | -1 | Terminator Salvation | $16,140,000 | $16,433,365 | +$293,365 | +1.8% | 3,602 | $90,657,000 | $90,949,924 | 2 | Warner Bros. | - |
| 5 | 5 | - | Star Trek | $12,800,000 | $12,613,727 | -$186,273 | -1.5% | 3,507 | $209,500,000 | $209,313,884 | 4 | Paramount Pictures | - |
| 6 | 6 | - | Angels & Demons | $11,200,000 | $11,353,340 | +$153,340 | +1.4% | 3,464 | $104,760,000 | $104,913,439 | 3 | Sony Pictures Releasing | - |
| 7 | 7 | - | Dance Flick | $4,900,000 | $4,743,636 | -$156,364 | -3.2% | 2,459 | $19,241,000 | $19,084,907 | 2 | Paramount Pictures | - |
| 8 | 8 | - | X-Men Origins: Wolverine | $3,900,000 | $3,873,377 | -$26,623 | -0.7% | 2,263 | $170,870,000 | $170,843,712 | 5 | Twentieth Century Fox | - |
| 9 | 9 | - | Ghosts of Girlfriends Past | $1,905,000 | $1,911,401 | +$6,401 | +0.3% | 1,450 | $50,015,000 | $50,021,779 | 5 | Warner Bros. | - |
| 10 | 10 | - | Obsessed | $665,000 | $657,001 | -$7,999 | -1.2% | 679 | $67,508,000 | $67,500,481 | 6 | Screen Gems | - |
| 11 | 11 | - | The Brothers Bloom | $652,000 | $627,971 | -$24,029 | -3.7% | 148 | $1,384,000 | $1,360,130 | 3 | Summit Entertainment | - |
| 12 | 12 | - | The Soloist | $500,000 | $485,215 | -$14,785 | -3% | 412 | $30,266,000 | $30,251,623 | 6 | DreamWorks | - |
| 13 | 14 | +1 | 17 Again | $338,000 | $339,549 | +$1,549 | +0.5% | 405 | $61,232,000 | $61,233,890 | 7 | Warner Bros. | - |
| 14 | 16 | +2 | Monsters vs. Aliens | $315,000 | $320,040 | +$5,040 | +1.6% | 566 | $194,417,000 | $194,421,864 | 10 | DreamWorks | - |
| 15 | 18 | +3 | Fast & Furious | $233,000 | $242,190 | +$9,190 | +3.9% | 299 | $153,937,000 | $153,945,790 | 9 | Universal Pictures | - |
| 16 | 21 | +5 | State of Play | $208,000 | $193,200 | -$14,800 | -7.1% | 240 | $36,582,000 | $36,566,450 | 7 | Universal Pictures | - |
| 17 | 22 | +5 | Summer Hours | $208,000 | $183,197 | -$24,803 | -11.9% | 38 | $578,000 | $554,165 | 3 | IFC Films | - |
| 18 | 20 | +2 | Next Day Air | $190,000 | $202,652 | +$12,652 | +6.7% | 235 | $9,467,000 | $9,479,286 | 4 | Summit Entertainment | - |
| 19 | 23 | +4 | Easy Virtue | $187,000 | $165,964 | -$21,036 | -11.2% | 26 | $361,000 | $339,881 | 2 | Sony Pictures Classics | - |
| 20 | 24 | +4 | Rudo y Cursi | $154,000 | $155,830 | +$1,830 | +1.2% | 108 | $1,443,000 | $1,445,429 | 4 | Sony Pictures Classics | - |
| 21 | 26 | +5 | I Love You, Man | $135,000 | $136,228 | +$1,228 | +0.9% | 228 | $71,346,000 | $71,347,010 | 11 | DreamWorks | - |
| 22 | 29 | +7 | Every Little Step | $131,000 | $125,475 | -$5,525 | -4.2% | 57 | $921,000 | $915,028 | 7 | Sony Pictures Classics | - |
| 23 | 30 | +7 | Is Anybody There? | $128,000 | $125,292 | -$2,708 | -2.1% | 119 | $1,760,000 | $1,756,479 | 7 | - | - |
| 24 | 28 | +4 | Knowing | $124,000 | $127,943 | +$3,943 | +3.2% | 195 | $79,391,000 | $79,395,115 | 11 | Summit Entertainment | - |
| 25 | 27 | +2 | Fighting | $117,000 | $134,425 | +$17,425 | +14.9% | 168 | $22,864,000 | $22,881,910 | 6 | Universal Pictures | - |
| 26 | 33 | +7 | Departures | $72,700 | $74,945 | +$2,245 | +3.1% | 9 | $72,700 | $74,945 | 1 | Regent Releasing | - |
| 27 | 34 | +7 | Valentino: The Last Emperor | $63,000 | $68,343 | +$5,343 | +8.5% | 35 | $1,225,000 | $1,193,635 | 11 | Truly Indie | - |
| 28 | 36 | +8 | Sin Nombre | $56,800 | $57,161 | +$361 | +0.6% | 53 | $2,375,000 | $2,374,932 | 11 | Focus Features | - |
| 29 | 40 | +11 | Sugar | $51,900 | $48,178 | -$3,722 | -7.2% | 51 | $906,000 | $901,906 | 9 | Sony Pictures Classics | - |
| 30 | 41 | +11 | Tyson | $41,900 | $40,713 | -$1,187 | -2.8% | 27 | $686,000 | $684,799 | 6 | Sony Pictures Classics | - |
| 31 | 43 | +12 | Anvil: The Story of Anvil | $34,100 | $34,100 | $0 | - | 20 | $493,000 | $492,513 | 8 | Abramorama | - |
| 32 | 45 | +13 | The Limits of Control | $28,200 | $28,155 | -$45 | -0.2% | 20 | $317,000 | $316,339 | 5 | Focus Features | - |
| 33 | 53 | +20 | Adoration | $21,200 | $18,254 | -$2,946 | -13.9% | 18 | $169,000 | $166,367 | 4 | Sony Pictures Classics | - |
| 34 | 50 | +16 | Paris 36 | $18,000 | $20,059 | +$2,059 | +11.4% | 31 | $810,000 | $812,429 | 9 | Sony Pictures Classics | - |
| 35 | 54 | +19 | Coraline | $15,500 | $17,886 | +$2,386 | +15.4% | 36 | $75,193,000 | $75,195,256 | 17 | Focus Features | - |
| 36 | 57 | +21 | O'Horten | $14,800 | $14,502 | -$298 | -2% | 9 | $55,900 | $55,646 | 2 | Sony Pictures Classics | - |
