| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum: Battle of the Smithsonian | $2,686,396 | -27.4% | 397 | - | $6,766 | $7,201,408 | 2 | 20th Century Fox International | false | false |
| 2 | 2 | Angels & Demons | $1,658,319 | -38% | 425 | -9 | $3,901 | $10,828,830 | 3 | Sony Pictures Releasing | false | false |
| 3 | - | State of Play | $1,585,671 | - | 242 | - | $6,552 | $1,615,888 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | 3 | Star Trek | $989,042 | -36% | 286 | -16 | $3,458 | $10,806,745 | 4 | Paramount Pictures International | false | false |
| 5 | 4 | X-Men Origins: Wolverine | $480,235 | -40.6% | 231 | -49 | $2,078 | $14,223,548 | 5 | 20th Century Fox International | false | false |
| 6 | 5 | Ghosts of Girlfriends Past | $419,456 | -35.9% | 188 | -30 | $2,231 | $4,554,000 | 4 | Roadshow Films | false | false |
| 7 | - | I Love You, Man | $281,561 | - | 169 | - | $1,666 | $302,640 | - | Paramount Pictures International | - | false |
| 8 | 8 | Samson & Delilah | $218,910 | +20.2% | 19 | +3 | $11,521 | $981,175 | 4 | Paramount Pictures International | false | false |
| 9 | 17 | My Year Without Sex | $142,052 | +338.3% | 25 | +5 | $5,682 | $176,033 | 2 | Paramount Pictures International | false | false |
| 10 | 7 | Defiance | $115,982 | -45.2% | 106 | -32 | $1,094 | $2,758,168 | 5 | Roadshow Films | false | false |
| 11 | 9 | The Boy in the Striped Pajamas | $103,417 | -28.9% | 104 | - | $994 | $2,664,378 | 6 | Walt Disney Pictures | false | false |
| 12 | 6 | Observe and Report | $95,762 | -55.9% | 109 | -21 | $878 | $912,486 | 3 | Warner Bros. | false | false |
| 13 | 12 | Children of Winter | $92,170 | +16.2% | 3 | +1 | $30,723 | $184,708 | 2 | - | false | false |
| 14 | 10 | What Just Happened | $61,916 | -56% | 35 | - | $1,769 | $253,203 | 2 | Hopscotch Films | false | false |
| 15 | - | Adventureland | $48,742 | - | 41 | - | $1,188 | $48,742 | 1 | Roadshow Films | true | false |
| 16 | 13 | Gomorrah | $46,365 | -35.3% | 17 | +2 | $2,727 | $263,565 | 3 | Madman Entertainment | false | false |
| 17 | 11 | Fast & Furious | $41,043 | -59.9% | 54 | -47 | $760 | $13,665,948 | 8 | Universal Pictures International (UPI) | false | false |
| 18 | 14 | Monsters vs. Aliens | $27,607 | -48% | 35 | -48 | $788 | $16,388,658 | 9 | Paramount Pictures International | false | false |
| 19 | 16 | 17 Again | $25,537 | -37.4% | 41 | -35 | $622 | $10,079,700 | 8 | Roadshow Films | false | false |
| 20 | 15 | Vampire Killers | $24,954 | -52.9% | 39 | -1 | $639 | $100,104 | 2 | Paramount Pictures International | false | false |
| 21 | - | The Merchants of Bollywood | $20,691 | - | 21 | - | $985 | $20,691 | 1 | N/A | true | false |
| 22 | - | Is Anybody There? | $19,218 | - | 32 | - | $600 | $19,218 | - | Hopscotch Films | - | false |
| 23 | - | Katyn | $16,841 | - | 10 | - | $1,684 | $16,841 | 1 | N/A | true | false |
