| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Angels & Demons | $482,767 | -44.8% | 98 | - | $4,926 | $2,822,769 | 3 | Sony Pictures Releasing | false | false |
| 2 | 2 | Night at the Museum: Battle of the Smithsonian | $372,948 | -42.7% | 85 | - | $4,387 | $1,071,989 | 2 | 20th Century Fox International | false | false |
| 3 | 3 | 17 Again | $108,810 | -43.1% | 36 | - | $3,022 | $845,456 | 4 | Kinepolis Film Distribution (KFD) | false | false |
| 4 | 4 | X-Men Origins: Wolverine | $103,720 | -45.7% | 100 | - | $1,037 | $2,034,552 | 5 | 20th Century Fox International | false | false |
| 5 | 5 | Star Trek | $81,037 | -41.1% | 43 | +1 | $1,884 | $827,862 | 4 | Universal Pictures International (UPI) | false | false |
| 6 | 6 | The Girl with the Dragon Tattoo | $76,217 | -33.9% | 42 | - | $1,814 | $257,815 | 2 | Benelux Film Distributors | false | false |
| 7 | 8 | He's Just Not That Into You | $43,305 | -35.3% | 24 | - | $1,804 | $992,299 | 6 | Paradiso Entertainment | false | false |
| 8 | 7 | My Bloody Valentine | $43,049 | -40.6% | 14 | -1 | $3,074 | $464,014 | 5 | Kinepolis Film Distribution (KFD) | false | false |
| 9 | 9 | Sister Smile | $34,278 | -44.1% | 33 | - | $1,038 | $450,482 | 4 | Kinepolis Film Distribution (KFD) | false | false |
| 10 | 11 | Knowing | $30,682 | -26% | 17 | - | $1,804 | $2,509,758 | 9 | Belga Films | false | false |
| 11 | 10 | Fast & Furious | $28,297 | -45.1% | 33 | -7 | $857 | $3,173,182 | 8 | Universal Pictures International (UPI) | false | false |
| 12 | - | Bank Error in Your Favour | $26,454 | - | 14 | - | $1,889 | $27,870 | 1 | Cinéart | true | false |
| 13 | 13 | Beverly Hills Chihuahua | $21,763 | -44.8% | 40 | +4 | $544 | $1,132,935 | 9 | Walt Disney Pictures | false | false |
| 14 | 14 | Coco Before Chanel | $18,353 | -46.6% | 29 | - | $632 | $567,090 | 6 | Kinepolis Film Distribution (KFD) | false | false |
| 15 | 18 | The Last House on the Left | $17,910 | -11.8% | 16 | +1 | $1,119 | $336,217 | 6 | Universal Pictures International (UPI) | false | false |
| 16 | 12 | Monsters vs. Aliens | $17,149 | -56.9% | 56 | -7 | $306 | $1,606,393 | 9 | Universal Pictures International (UPI) | false | false |
| 17 | 15 | Incognito | $16,984 | -39.7% | 15 | +1 | $1,132 | $273,446 | 5 | Alternative Films | false | false |
| 18 | 16 | Slumdog Millionaire | $14,231 | -36.7% | 23 | -2 | $618 | $3,599,382 | 20 | Cinéart | false | false |
| 19 | 19 | Je l'aimais | $13,219 | -16% | 14 | +3 | $944 | $130,151 | 4 | N/A | false | false |
| 20 | - | Vengeance | $10,397 | - | 16 | - | $649 | $11,439 | 1 | N/A | true | false |
| 21 | 17 | OSS 117: Lost in Rio | $9,628 | -53.5% | 12 | -1 | $802 | $723,104 | 7 | Belga Films | false | false |
| 22 | 21 | The Boy in the Striped Pajamas | $9,280 | -10.3% | 11 | - | $843 | $114,840 | 5 | Walt Disney Pictures | false | false |
| 23 | 20 | S&M Judge | $6,577 | -38.3% | 12 | - | $548 | $1,070,669 | 12 | Kinepolis Film Distribution (KFD) | false | false |
| 24 | 22 | In the Electric Mist | $5,023 | -50.6% | 5 | -8 | $1,004 | $231,503 | 6 | Benelux Film Distributors | false | false |
| 25 | 23 | The Boat That Rocked | $4,160 | -24.7% | 5 | -7 | $832 | $77,188 | 4 | Universal Pictures International (UPI) | false | false |
| 26 | 32 | Duplicity | $3,052 | <0.1% | 2 | - | $1,526 | $914,014 | 10 | Universal Pictures International (UPI) | false | false |
| 27 | 25 | London River | $2,999 | -36.8% | 10 | - | $299 | $66,244 | 5 | ABC Distribution | false | false |
| 28 | - | Eden Is West | $2,858 | - | 3 | - | $952 | $2,858 | 1 | Alternative Films | true | false |
| 29 | 24 | The Reader | $2,434 | -50.4% | 9 | -4 | $270 | $842,429 | 13 | Benelux Film Distributors | false | false |
| 30 | 26 | Tokyo Sonata | $2,202 | -50.2% | 2 | - | $1,101 | $10,105 | 2 | A-Film Distribution | false | false |
| 31 | 30 | Gran Torino | $2,075 | -40.8% | 11 | +6 | $188 | $1,126,546 | 14 | Warner Bros. | false | false |
| 32 | 27 | Ponyo | $2,010 | -52.8% | 7 | -1 | $287 | $99,491 | 8 | Cinéart | false | false |
| 33 | 34 | Synecdoche, New York | $1,744 | -35.6% | 3 | -1 | $581 | $12,484 | 3 | Paradiso Entertainment | false | false |
| 34 | 33 | Bolt | $1,621 | -40.8% | 4 | +2 | $405 | $3,148,785 | 16 | Walt Disney Pictures | false | false |
| 35 | 31 | Make It Happen | $1,415 | -56.5% | 6 | -9 | $235 | $330,975 | 8 | Benelux Film Distributors | false | false |
| 36 | 39 | Chéri | $1,062 | -11.9% | 6 | -4 | $177 | $246,271 | 8 | Benelux Film Distributors | false | false |
| 37 | 29 | Hotel for Dogs | $1,040 | -70.5% | 4 | -6 | $260 | $1,240,649 | 15 | Universal Pictures International (UPI) | false | false |
| 38 | 28 | Jonas Brothers: The 3D Concert Experience | $987 | -72.7% | 9 | - | $109 | $12,913 | 3 | Walt Disney Pictures | false | false |
