| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Hannah Montana: The Movie | $36,949,154 | - | 3,118 | - | $11,850 | $36,949,154 | 1 | Walt Disney Studios Motion Pictures | true | false |
| 2 | - | Fast & Furious | $29,893,985 | - | 3,472 | - | $8,610 | $119,153,175 | 2 | Universal Pictures | false | false |
| 3 | - | Monsters vs. Aliens | $25,191,075 | - | 4,136 | - | $6,090 | $143,582,621 | 3 | DreamWorks | false | false |
| 4 | - | Observe and Report | $12,119,347 | - | 2,727 | - | $4,444 | $12,119,347 | 1 | Warner Bros. | true | false |
| 5 | - | Knowing | $7,159,317 | - | 2,925 | - | $2,447 | $68,495,434 | 4 | Summit Entertainment | false | false |
| 6 | - | I Love You, Man | $6,979,595 | - | 2,643 | - | $2,640 | $59,564,024 | 4 | DreamWorks | false | false |
| 7 | - | The Haunting in Connecticut | $6,602,878 | - | 2,721 | - | $2,426 | $47,190,243 | 3 | Lionsgate Films | false | false |
| 8 | - | Dragonball Evolution | $5,278,423 | - | 2,181 | - | $2,420 | $5,278,423 | 1 | Twentieth Century Fox | true | false |
| 9 | - | Adventureland | $3,754,832 | - | 1,876 | - | $2,001 | $11,772,123 | 2 | Miramax | false | false |
| 10 | - | Duplicity | $3,280,775 | - | 1,965 | - | $1,669 | $37,132,370 | 4 | Universal Pictures | false | false |
| 11 | - | Race to Witch Mountain | $2,239,571 | - | 2,172 | - | $1,031 | $62,295,034 | 5 | Walt Disney Studios Motion Pictures | false | false |
| 12 | - | Sunshine Cleaning | $1,895,544 | - | 598 | - | $3,169 | $7,314,801 | 5 | Overture Films | false | false |
| 13 | - | Taken | $1,195,885 | - | 872 | - | $1,371 | $141,220,642 | 11 | Twentieth Century Fox | false | false |
| 14 | - | 12 Rounds | $887,165 | - | 908 | - | $977 | $10,847,829 | 3 | Twentieth Century Fox | false | false |
| 15 | - | The Last House on the Left | $651,035 | - | 623 | - | $1,045 | $31,794,770 | 5 | Universal Pictures | false | false |
| 16 | - | Watchmen | $620,756 | - | 453 | - | $1,370 | $106,484,772 | 6 | Warner Bros. | false | false |
| 17 | - | Paul Blart: Mall Cop | $596,019 | - | 514 | - | $1,159 | $143,956,523 | 13 | Sony Pictures Releasing | false | false |
| 18 | - | Under the Sea 3D | $372,934 | - | 43 | - | $8,672 | $5,412,286 | 9 | Warner Bros. | false | false |
| 19 | - | Sin Nombre | $362,768 | - | 65 | - | $5,581 | $836,262 | 4 | Focus Features | false | false |
| 20 | - | Slumdog Millionaire | $316,961 | - | 306 | - | $1,035 | $140,785,786 | 22 | - | false | false |
| 21 | - | Hotel for Dogs | $274,396 | - | 347 | - | $790 | $72,010,015 | 13 | DreamWorks | false | false |
| 22 | - | Gran Torino | $239,996 | - | 237 | - | $1,012 | $146,586,608 | 18 | Warner Bros. | false | false |
| 23 | - | Madea Goes to Jail | $227,682 | - | 326 | - | $698 | $90,323,311 | 8 | Lionsgate Films | false | false |
| 24 | - | Coraline | $206,817 | - | 233 | - | $887 | $74,574,118 | 10 | Focus Features | false | false |
| 25 | - | He's Just Not That Into You | $157,560 | - | 156 | - | $1,010 | $93,158,098 | 10 | Warner Bros. | false | false |
| 26 | - | The Reader | $116,735 | - | 132 | - | $884 | $34,018,145 | 18 | The Weinstein Company | false | false |
| 27 | - | Push | $114,781 | - | 162 | - | $708 | $31,518,112 | 10 | Summit Entertainment | false | false |
| 28 | - | The Curious Case of Benjamin Button | $92,998 | - | 156 | - | $596 | $127,403,901 | 16 | Paramount Pictures | false | false |
| 29 | - | Goodbye Solo | $71,379 | - | 11 | - | $6,489 | $165,574 | 3 | Roadside Attractions | false | false |
| 30 | - | The Wrestler | $50,381 | - | 78 | - | $645 | $26,142,362 | 17 | - | false | false |
| 31 | - | Friday the 13th | $49,021 | - | 112 | - | $437 | $64,964,815 | 9 | Warner Bros. | false | false |
| 32 | - | Bride Wars | $42,326 | - | 66 | - | $641 | $58,643,657 | 14 | Twentieth Century Fox | false | false |
| 33 | - | Last Chance Harvey | $38,835 | - | 35 | - | $1,109 | $14,844,518 | 16 | Overture Films | false | false |
| 34 | - | Defiance | $32,563 | - | 47 | - | $692 | $28,555,778 | 15 | Paramount Vantage | false | false |
| 35 | - | Street Fighter: The Legend of Chun-Li | $32,368 | - | 34 | - | $952 | $8,697,304 | 7 | Twentieth Century Fox | false | false |
| 36 | - | Royal Kill | $28,149 | - | 5 | - | $5,629 | $28,149 | 1 | 21st Century Film Production | true | false |
| 37 | - | Marley & Me | $23,548 | - | 48 | - | $490 | $143,129,024 | 16 | Twentieth Century Fox | false | false |
| 38 | - | Fanboys | $17,125 | - | 32 | - | $535 | $673,406 | 10 | The Weinstein Company | false | false |
| 39 | - | Enlighten Up! | $11,071 | - | 1 | - | $11,071 | $72,413 | 31 | Balcony Releasing | false | false |
| 40 | - | Alien Trespass | $10,717 | - | 22 | - | $487 | $72,870 | 2 | Roadside Attractions | false | false |
| 41 | - | Crossing Over | $10,453 | - | 21 | - | $497 | $447,065 | 7 | The Weinstein Company | false | false |
| 42 | - | Milk | $10,422 | - | 13 | - | $801 | $31,838,727 | 20 | Focus Features | false | false |
| 43 | - | Bart Got a Room | $9,249 | - | 4 | - | $2,312 | $51,443 | 2 | Anchor Bay Films | false | false |
| 44 | - | Miss March | $5,336 | - | 14 | - | $381 | $4,535,395 | 5 | - | false | false |
| 45 | - | Between Love & Goodbye | $1,989 | - | 2 | - | $994 | $16,783 | 11 | Embrem Entertainment | false | false |
| 46 | - | Throw Down Your Heart | $1,671 | - | 1 | - | $1,671 | $14,166 | 5 | Argot Pictures | false | false |
| 47 | - | Were the World Mine | $1,374 | - | 1 | - | $1,374 | $122,219 | 24 | - | false | false |
| 48 | - | Valkyrie | $818 | - | 7 | - | $116 | $83,077,586 | 16 | United Artists | false | false |
| 49 | - | Made in U.S.A | $686 | - | 1 | - | $686 | $80,579 | 14 | Rialto Pictures | false | false |
