| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Fast & Furious | $528,470 | - | 45 | - | $11,743 | $528,470 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | - | Esperando la carroza 2: Se acabó la fiesta | $421,882 | - | 88 | - | $4,794 | $421,882 | 1 | Primer Plano Film Group | true | false |
| 3 | - | Monsters vs. Aliens | $421,173 | - | 91 | - | $4,628 | $421,173 | 1 | Paramount Pictures International | true | false |
| 4 | - | Knowing | $313,154 | - | 49 | - | $6,390 | $313,154 | 1 | Alfa Films | true | false |
| 5 | 1 | Música en espera | $130,393 | +9.6% | 38 | -1 | $3,431 | $555,025 | 3 | Distribution Company | false | false |
| 6 | 2 | The International | $71,811 | -17.7% | 30 | - | $2,393 | $190,978 | 2 | Sony Pictures Releasing | false | false |
| 7 | 4 | Slumdog Millionaire | $71,321 | +3.6% | 43 | - | $1,658 | $1,385,213 | 8 | Distribution Company | false | false |
| 8 | 5 | He's Just Not That Into You | $67,169 | +2.2% | 33 | +2 | $2,035 | $706,729 | 5 | Distribution Company | false | false |
| 9 | 3 | Gran Torino | $66,055 | -9.8% | 50 | -1 | $1,321 | $776,613 | 5 | Warner Bros. | false | false |
| 10 | 6 | Confessions of a Shopaholic | $45,058 | -22.3% | 44 | -2 | $1,024 | $280,987 | 3 | Walt Disney Pictures | false | false |
| 11 | 7 | Transporter 3 | $30,006 | -29.5% | 39 | -3 | $769 | $350,591 | 4 | - | false | false |
| 12 | 8 | Bedtime Stories | $28,424 | -31.7% | 44 | -27 | $646 | $2,070,113 | 9 | Walt Disney Pictures | false | false |
| 13 | - | Rumba | $26,523 | - | 8 | - | $3,315 | $26,523 | 1 | Distribution Company | true | false |
| 14 | 14 | The Edge of Heaven | $24,635 | +4.9% | 12 | -1 | $2,052 | $111,778 | 3 | Alfa Films | false | false |
| 15 | 11 | Hotel for Dogs | $24,154 | -18.2% | 41 | - | $589 | $592,453 | 7 | Paramount Pictures International | false | false |
| 16 | 15 | Paris | $19,349 | -9.1% | 11 | -5 | $1,759 | $182,757 | 4 | Impacto Cine | false | false |
| 17 | 12 | Gomorrah | $15,922 | -34.9% | 18 | -15 | $884 | $235,200 | 4 | Alfa Films | false | false |
| 18 | 10 | The Curious Case of Benjamin Button | $13,806 | -58.7% | 34 | -31 | $406 | $2,034,973 | 9 | Warner Bros. | false | false |
| 19 | 9 | Push | $12,425 | -66.1% | 15 | -10 | $828 | $60,626 | 2 | Alfa Films | false | false |
| 20 | 13 | Bonneville | $10,751 | -55.2% | 11 | -3 | $977 | $40,989 | 2 | Impacto Cine | false | false |
| 21 | 17 | Bride Wars | $10,057 | -49.5% | 20 | -17 | $502 | $384,383 | 6 | 20th Century Fox International | false | false |
| 22 | 21 | Seven Pounds | $7,018 | -39.1% | 12 | -4 | $584 | $255,866 | 6 | Sony Pictures Releasing | false | false |
| 23 | 18 | Coraline | $6,724 | -65.2% | 11 | -13 | $611 | $126,177 | 4 | Universal Pictures International (UPI) | false | false |
| 24 | 19 | Fireflies in the Garden 2008 Re-release | $5,346 | -71% | 11 | -3 | $486 | $29,579 | 2 | - | false | false |
| 25 | 22 | Mundo alas | $5,154 | -42.2% | 8 | - | $644 | $17,309 | 2 | Distribution Company | false | false |
| 26 | 28 | Unfair Competition 2009 Re-release | $4,617 | +11.7% | 3 | -1 | $1,539 | $37,308 | 5 | Primer Plano Film Group | false | false |
| 27 | 20 | Vicky Cristina Barcelona | $4,605 | -66.6% | 17 | -22 | $270 | $768,894 | 9 | Pachamama Cine | false | false |
| 28 | 24 | Friday the 13th | $4,038 | -27.1% | 11 | -10 | $367 | $391,821 | 8 | Paramount Pictures International | false | false |
| 29 | 30 | Doubt | $1,445 | -53.3% | 6 | -8 | $240 | $535,039 | 12 | Walt Disney Pictures | false | false |
| 30 | 23 | Be Kind Rewind | $1,389 | -81% | 3 | -10 | $463 | $50,631 | 4 | Distribution Company | false | false |
| 31 | 43 | Madagascar: Escape 2 Africa | $1,099 | +198.6% | 3 | -1 | $366 | $5,065,472 | 18 | Paramount Pictures International | false | false |
| 32 | 37 | Milk | $963 | +14.9% | 4 | -4 | $240 | $236,471 | 8 | Universal Pictures International (UPI) | false | false |
| 33 | 40 | Bolt | $947 | +63% | 7 | +1 | $135 | $2,117,693 | 12 | Walt Disney Pictures | false | false |
| 34 | 16 | Watchmen | $848 | -96% | 5 | -36 | $169 | $428,444 | 5 | Paramount Pictures International | false | false |
| 35 | 32 | The Window | $778 | -70.3% | 3 | -6 | $259 | $31,738 | 4 | Distribution Company | false | false |
| 36 | 27 | The Pink Panther 2 | $722 | -82.6% | 7 | -7 | $103 | $240,887 | 7 | Sony Pictures Releasing | false | false |
| 37 | 26 | The Secret Life of Bees | $526 | -87.9% | 3 | -7 | $175 | $16,992 | 4 | 20th Century Fox International | false | false |
| 38 | - | The Tracker 2008 Re-release | $492 | - | 1 | - | $492 | $168,175 | 15 | IFA | false | false |
| 39 | - | Palabra por palabra | $456 | - | 1 | - | $456 | $4,880 | 52 | Primer Plano Film Group | false | false |
| 40 | 34 | Changeling | $407 | -77.9% | 3 | -5 | $135 | $888,980 | 11 | Universal Pictures International (UPI) | false | false |
| 41 | 29 | Death Proof | $401 | -88.2% | 2 | -5 | $200 | $47,515 | 6 | Pachamama Cine | false | false |
| 42 | 33 | Lovely Loneliness | $292 | -87.1% | 1 | -6 | $292 | $47,234 | 5 | Pachamama Cine | false | false |
| 43 | 36 | Revolutionary Road | $221 | -75.4% | 2 | -4 | $110 | $289,433 | 10 | Paramount Pictures International | false | false |
| 44 | - | High School Musical 3: Senior Year | $181 | - | 1 | - | $181 | $1,314,788 | 19 | Walt Disney Pictures | false | false |
| 45 | 47 | Am Ende kommen Touristen | $163 | +10.1% | 1 | - | $163 | $14,943 | 7 | Alfa Films | false | false |
| 46 | 49 | The Tale of Despereaux | $145 | +107.1% | 2 | +1 | $72 | $176,256 | 9 | United International Pictures | false | false |
| 47 | 25 | Valkyrie | $133 | -97.1% | 4 | -17 | $33 | $727,580 | 8 | 20th Century Fox International | false | false |
| 48 | 45 | Hielos míticos | $130 | -34% | 1 | - | $130 | $709 | 3 | N/A | false | false |
| 49 | 31 | The Wrestler | $76 | -97.4% | 1 | -11 | $76 | $191,360 | 7 | Distribution Company | false | false |
| 50 | 51 | Emma's Bliss | $65 | +51.2% | 1 | - | $65 | $26,523 | 10 | Primer Plano Film Group | false | false |
| 51 | 46 | Back to Fortin Olmos | $58 | -64% | 1 | -1 | $58 | $1,820 | 5 | Primer Plano Film Group | false | false |
| 52 | 42 | Underworld: Rise of the Lycans | $35 | -92.4% | 1 | -3 | $35 | $375,423 | 9 | Sony Pictures Releasing | false | false |
| 53 | 52 | Cartas a Malvinas | $34 | +17.2% | 1 | - | $34 | $281 | 3 | N/A | false | false |
| 54 | 44 | Blame it on Fidel | $27 | -92.2% | 1 | -2 | $27 | $38,824 | 11 | Zeta Films | false | false |
| 55 | 53 | Saw V | $9 | -47.1% | 1 | - | $9 | $1,076,755 | 23 | Walt Disney Pictures | false | false |
