| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Monsters vs. Aliens | $58,200,000 | $59,321,095 | +$1,121,095 | +1.9% | 4,104 | $58,200,000 | $59,321,095 | 1 | DreamWorks | - |
| 2 | 2 | - | The Haunting in Connecticut | $23,010,000 | $23,004,765 | -$5,235 | <0.1% | 2,732 | $23,010,000 | $23,004,765 | 1 | Lionsgate | - |
| 3 | 3 | - | Knowing | $14,705,000 | $14,702,187 | -$2,813 | <0.1% | 3,337 | $46,220,000 | $46,217,199 | 2 | Summit Entertainment | - |
| 4 | 4 | - | I Love You, Man | $12,600,000 | $12,671,533 | +$71,533 | +0.6% | 2,717 | $37,007,000 | $37,078,306 | 2 | DreamWorks | - |
| 5 | 5 | - | Duplicity | $7,556,000 | $7,672,485 | +$116,485 | +1.5% | 2,579 | $25,639,000 | $25,754,865 | 2 | Universal Pictures | - |
| 6 | 6 | - | Race to Witch Mountain | $5,637,000 | $5,801,775 | +$164,775 | +2.9% | 3,268 | $53,295,000 | $53,459,752 | 3 | Walt Disney Studios Motion Pictures | - |
| 7 | 7 | - | 12 Rounds | $5,300,000 | $5,329,240 | +$29,240 | +0.6% | 2,331 | $5,300,000 | $5,329,240 | 1 | Twentieth Century Fox | - |
| 8 | 8 | - | Watchmen | $2,755,000 | $2,732,439 | -$22,561 | -0.8% | 2,010 | $103,296,000 | $103,273,462 | 4 | Warner Bros. | - |
| 9 | 9 | - | Taken | $2,700,000 | $2,695,342 | -$4,658 | -0.2% | 1,961 | $137,074,000 | $137,068,886 | 9 | Twentieth Century Fox | - |
| 10 | 10 | - | The Last House on the Left | $2,611,000 | $2,644,295 | +$33,295 | +1.3% | 2,251 | $28,459,000 | $28,492,330 | 3 | Universal Pictures | - |
| 11 | 11 | - | Sunshine Cleaning | $1,344,000 | $1,274,007 | -$69,993 | -5.2% | 167 | $2,548,000 | $2,477,704 | 3 | Overture Films | - |
| 12 | 12 | - | Slumdog Millionaire | $1,135,000 | $1,164,903 | +$29,903 | +2.6% | 840 | $139,312,000 | $139,341,484 | 20 | Fox Searchlight Pictures | - |
| 13 | 13 | - | Madea Goes to Jail | $1,090,000 | $1,133,085 | +$43,085 | +4% | 1,128 | $89,024,000 | $89,067,436 | 6 | Lionsgate | - |
| 14 | 14 | - | Paul Blart: Mall Cop | $825,000 | $840,596 | +$15,596 | +1.9% | 1,082 | $142,488,000 | $142,503,850 | 11 | Sony Pictures Releasing | - |
| 15 | 15 | - | He's Just Not That Into You | $470,000 | $473,269 | +$3,269 | +0.7% | 506 | $92,508,000 | $92,510,829 | 8 | Warner Bros. | - |
| 16 | 16 | - | Gran Torino | $430,000 | $438,481 | +$8,481 | +2% | 478 | $145,807,000 | $145,815,056 | 16 | Warner Bros. | - |
| 17 | 18 | +1 | The Cross | $327,000 | $309,455 | -$17,545 | -5.4% | 221 | $327,000 | $309,455 | 1 | 8x Entertainment | - |
| 18 | 19 | +1 | The Reader | $310,000 | $308,495 | -$1,505 | -0.5% | 324 | $33,486,000 | $33,484,347 | 16 | The Weinstein Company | - |
| 19 | 17 | -2 | Hotel for Dogs | $303,000 | $314,942 | +$11,942 | +3.9% | 381 | $71,342,000 | $71,353,470 | 11 | DreamWorks | - |
| 20 | 20 | - | Coraline | $301,000 | $305,114 | +$4,114 | +1.4% | 360 | $73,926,000 | $73,929,936 | 8 | Focus Features | - |
| 21 | 22 | +1 | The Curious Case of Benjamin Button | $196,000 | $208,157 | +$12,157 | +6.2% | 246 | $127,011,000 | $127,023,019 | 14 | Paramount Pictures | - |
| 22 | 25 | +3 | The Class | $196,000 | $181,697 | -$14,303 | -7.3% | 123 | $3,078,000 | $3,064,397 | 15 | Sony Pictures Classics | - |
| 23 | 32 | +9 | Push | $88,000 | $92,307 | +$4,307 | +4.9% | 123 | $31,152,000 | $31,156,387 | 8 | Summit Entertainment | - |
| 24 | 34 | +10 | Doubt | $78,000 | $82,339 | +$4,339 | +5.6% | 115 | $33,332,000 | $33,337,239 | 16 | Miramax | - |
| 25 | 35 | +10 | The Uninvited | $71,000 | $74,688 | +$3,688 | +5.2% | 170 | $28,570,000 | $28,573,173 | 9 | DreamWorks | - |
| 26 | 36 | +10 | Sin Nombre | $68,500 | $70,167 | +$1,667 | +2.4% | 6 | $184,000 | $185,874 | 2 | Focus Features | - |
| 27 | 38 | +11 | Revolutionary Road | $62,000 | $63,113 | +$1,113 | +1.8% | 142 | $22,877,000 | $22,877,808 | 14 | Paramount Vantage | - |
| 28 | 41 | +13 | Defiance | $47,000 | $48,982 | +$1,982 | +4.2% | 80 | $28,470,000 | $28,471,672 | 13 | Paramount Vantage | - |
| 29 | 43 | +14 | Twilight | $44,000 | $42,434 | -$1,566 | -3.6% | 150 | $191,451,000 | $191,449,475 | 19 | Summit Entertainment | - |
| 30 | 47 | +17 | Goodbye Solo | $40,500 | $38,042 | -$2,458 | -6.1% | 3 | $40,500 | $38,042 | 1 | Roadside Attractions | - |
| 31 | 48 | +17 | Crossing Over | $38,000 | $36,095 | -$1,905 | -5% | 42 | $404,000 | $402,469 | 5 | The Weinstein Company | - |
| 32 | 59 | +27 | Shall We Kiss? | $31,000 | $28,680 | -$2,320 | -7.5% | 4 | $31,000 | $28,680 | 1 | Music Box Films | - |
| 33 | 57 | +24 | Wendy and Lucy | $30,500 | $30,328 | -$172 | -0.6% | 32 | $746,000 | $745,566 | 16 | Oscilloscope | - |
| 34 | 56 | +22 | Valentino: The Last Emperor | $30,000 | $31,106 | +$1,106 | +3.7% | 2 | $88,400 | $89,527 | 2 | Truly Indie | - |
| 35 | 64 | +29 | Play the Game | $13,600 | $14,830 | +$1,230 | +9% | 13 | $216,000 | $217,290 | 5 | Slowhand Cinema Releasing | - |
| 36 | 66 | +30 | Valkyrie | $13,000 | $11,877 | -$1,123 | -8.6% | 32 | $83,068,000 | $83,066,918 | 14 | United Artists | - |
| 37 | 67 | +30 | Fanboys | $9,450 | $10,193 | +$743 | +7.9% | 28 | $622,000 | $622,879 | 8 | The Weinstein Company | - |
