| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Gran Torino | $1,672,192 | -13.1% | 323 | -9 | $5,177 | $7,501,202 | 3 | Warner Bros. | false | false |
| 2 | - | The New Monsters Today | $1,416,596 | - | 406 | - | $3,489 | $1,416,596 | 1 | Warner Bros. | true | false |
| 3 | 1 | La matassa | $1,133,715 | -52.2% | 318 | -180 | $3,565 | $8,852,116 | 3 | Medusa Distribuzione | false | false |
| 4 | 3 | Different from Whom | $1,092,855 | -22.3% | 358 | -6 | $3,052 | $3,032,952 | 2 | United International Pictures | false | false |
| 5 | - | Push | $957,979 | - | 197 | - | $4,862 | $957,979 | 1 | Eagle Pictures | true | false |
| 6 | 4 | He's Just Not That Into You | $889,546 | -34.5% | 298 | -25 | $2,985 | $2,752,034 | 2 | 01 Distribution | false | false |
| 7 | - | The Case of Unfaithful Klara | $621,216 | - | 262 | - | $2,371 | $621,216 | 1 | Medusa Distribuzione | true | false |
| 8 | - | Bedtime Stories | $502,583 | - | 87 | - | $5,776 | $502,583 | 1 | Walt Disney Pictures | true | false |
| 9 | 5 | The International | $383,612 | -34.8% | 160 | -10 | $2,397 | $1,173,432 | 2 | Sony Pictures Releasing | false | false |
| 10 | - | Two Lovers | $355,899 | - | 108 | - | $3,295 | $355,899 | 1 | BIM Distribuzione | true | false |
| 11 | 6 | Ponyo | $313,857 | -2.4% | 169 | -15 | $1,857 | $737,574 | 2 | Lucky Red | false | false |
| 12 | - | Fort Apache Napoli | $254,262 | - | 112 | - | $2,270 | $436,551 | 1 | 01 Distribution | true | false |
| 13 | 9 | Slumdog Millionaire | $146,975 | -37.2% | 70 | -37 | $2,099 | $7,835,288 | 17 | Lucky Red | false | false |
| 14 | 7 | Confessions of a Shopaholic | $96,101 | -68.2% | 58 | -99 | $1,656 | $6,078,853 | 5 | Walt Disney Pictures | false | false |
| 15 | 13 | The Reader | $71,976 | -43.8% | 29 | -35 | $2,481 | $3,126,861 | 6 | 01 Distribution | false | false |
| 16 | 8 | Watchmen | $71,926 | -75.4% | 42 | -121 | $1,712 | $3,628,771 | 4 | Universal Pictures International (UPI) | false | false |
| 17 | - | Cenci in Cina | $70,077 | - | 6 | - | $11,679 | $83,822 | 1 | N/A | true | false |
| 18 | 10 | The Wrestler | $60,219 | -72.7% | 39 | -96 | $1,544 | $2,732,519 | 4 | Lucky Red | false | false |
| 19 | - | Trappola d'autore | $56,556 | - | 9 | - | $6,284 | $58,729 | 1 | N/A | true | false |
| 20 | - | Teza | $55,685 | - | 21 | - | $2,651 | $55,685 | 1 | Ripley's Film | true | false |
| 21 | 12 | Due partite | $52,362 | -65.8% | 37 | -74 | $1,415 | $1,952,366 | 4 | 01 Distribution | false | false |
| 22 | 11 | The Curious Case of Benjamin Button | $48,416 | -69.9% | 25 | -52 | $1,936 | $14,419,696 | 7 | Warner Bros. | false | false |
| 23 | 25 | Journey to the Center of the Earth | $41,480 | +11.9% | 13 | -3 | $3,190 | $10,655,011 | 11 | 01 Distribution | false | false |
| 24 | 19 | The Wave | $31,932 | -37.5% | 18 | -13 | $1,774 | $527,514 | 5 | BIM Distribuzione | false | false |
| 25 | 21 | Frozen River | $29,306 | -33.4% | 13 | -7 | $2,254 | $150,065 | 3 | Archibald | false | false |
| 26 | 16 | The Pink Panther 2 | $27,825 | -74.9% | 30 | -69 | $927 | $1,339,271 | 4 | Sony Pictures Releasing | false | false |
| 27 | 22 | Inkheart | $16,535 | -59.3% | 18 | -21 | $918 | $3,238,280 | 6 | Eagle Pictures | false | false |
| 28 | 18 | The Unborn | $12,316 | -81.6% | 9 | -33 | $1,368 | $2,470,810 | 5 | Universal Pictures International (UPI) | false | false |
| 29 | 34 | Easy Virtue | $12,091 | +81.4% | 4 | -3 | $3,022 | $3,241,067 | 12 | Eagle Pictures | false | false |
| 30 | 20 | Giulia Doesn't Date at Night | $11,605 | -76.5% | 9 | -22 | $1,289 | $1,090,541 | 5 | 01 Distribution | false | false |
| 31 | 30 | Márió, a varázsló | $11,326 | +1.7% | 4 | +1 | $2,831 | $238,776 | 18 | L'Altrofilm | false | false |
| 32 | 17 | L'ultimo Crodino | $9,733 | -86.3% | 8 | -93 | $1,216 | $100,711 | 2 | Mikado Film | false | false |
| 33 | 27 | Milk | $9,730 | -51.5% | 6 | -7 | $1,621 | $3,238,238 | 10 | BIM Distribuzione | false | false |
| 34 | 37 | Eden Is West | $9,421 | +49.6% | 11 | - | $856 | $537,816 | 4 | Medusa Distribuzione | false | false |
| 35 | 14 | Mesrine: Killer Instinct | $9,058 | -92.4% | 8 | -98 | $1,132 | $704,920 | 3 | Eagle Pictures | false | false |
| 36 | 23 | Live! | $8,839 | -78% | 6 | -26 | $1,473 | $570,304 | 4 | Moviemax | false | false |
| 37 | 24 | Ex | $8,448 | -78.1% | 6 | -15 | $1,408 | $14,699,993 | 8 | 01 Distribution | false | false |
| 38 | 38 | Revolutionary Road | $8,285 | +31.8% | 4 | -4 | $2,071 | $4,753,518 | 9 | Universal Pictures International (UPI) | false | false |
| 39 | 32 | Katyn | $7,031 | -24.5% | 7 | -4 | $1,004 | $83,151 | 7 | N/A | false | false |
| 40 | 33 | Lemon Tree | $4,756 | -35.4% | 4 | -2 | $1,189 | $1,436,445 | 16 | Teodora Film | false | false |
| 41 | - | Empties | $4,754 | - | 5 | - | $950 | $419,055 | 11 | Fandango | false | false |
| 42 | 39 | Impy's Wonderland | $4,516 | -27.6% | 14 | -11 | $322 | $273,774 | 5 | Mediafilm | false | false |
| 43 | - | The First Day of Winter | $4,109 | - | 4 | - | $1,027 | $4,109 | 1 | N/A | true | false |
| 44 | 41 | I've Loved You So Long | $3,796 | -32% | 5 | +1 | $759 | $554,704 | 8 | Mikado Film | false | false |
| 45 | 51 | Hotel for Dogs | $3,709 | +332.8% | 6 | +4 | $618 | $98,529 | 6 | Universal Pictures International (UPI) | false | false |
| 46 | 42 | The Sicilian Girl | $3,185 | -42% | 5 | -4 | $637 | $183,995 | 5 | Istituto Luce | false | false |
| 47 | 29 | Underworld: Rise of the Lycans | $3,034 | -77.7% | 5 | -15 | $606 | $1,592,463 | 6 | Sony Pictures Releasing | false | false |
| 48 | 43 | Mar nero | $1,875 | -51.2% | 2 | -1 | $937 | $121,630 | 9 | N/A | false | false |
| 49 | 35 | The Boy in the Striped Pajamas | $1,609 | -75.7% | 4 | -3 | $402 | $3,528,256 | 15 | Walt Disney Pictures | false | false |
| 50 | 26 | Iago | $1,449 | -93.8% | 2 | -26 | $724 | $2,678,424 | 5 | Medusa Distribuzione | false | false |
| 51 | - | Appaloosa | $1,153 | - | 1 | - | $1,153 | $387,450 | 11 | 01 Distribution | false | false |
