| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Knowing | $24,814,000 | $24,604,751 | -$209,249 | -0.8% | 3,332 | $24,814,000 | $24,604,751 | 1 | Summit Entertainment | - |
| 2 | 2 | - | I Love You, Man | $18,005,000 | $17,810,270 | -$194,730 | -1.1% | 2,711 | $18,005,000 | $17,810,270 | 1 | DreamWorks | - |
| 3 | 3 | - | Duplicity | $14,402,000 | $13,965,110 | -$436,890 | -3% | 2,574 | $14,402,000 | $13,965,110 | 1 | Universal Pictures | - |
| 4 | 4 | - | Race to Witch Mountain | $13,004,000 | $12,786,041 | -$217,959 | -1.7% | 3,187 | $44,715,000 | $44,496,593 | 2 | Walt Disney Studios Motion Pictures | - |
| 5 | 5 | - | Watchmen | $6,725,000 | $6,801,114 | +$76,114 | +1.1% | 3,510 | $98,065,000 | $98,140,886 | 3 | Warner Bros. | - |
| 6 | 6 | - | The Last House on the Left | $5,921,000 | $5,776,160 | -$144,840 | -2.4% | 2,402 | $24,047,000 | $23,902,420 | 2 | Universal Pictures | - |
| 7 | 7 | - | Taken | $4,100,000 | $4,057,695 | -$42,305 | -1% | 2,661 | $133,139,000 | $133,096,403 | 8 | Twentieth Century Fox | - |
| 8 | 8 | - | Slumdog Millionaire | $2,700,000 | $2,676,369 | -$23,631 | -0.9% | 2,067 | $137,202,000 | $137,178,177 | 19 | Fox Searchlight Pictures | - |
| 9 | 9 | - | Madea Goes to Jail | $2,510,000 | $2,566,535 | +$56,535 | +2.3% | 1,835 | $87,208,000 | $87,264,219 | 5 | Lionsgate | - |
| 10 | 10 | - | Coraline | $2,143,000 | $2,130,746 | -$12,254 | -0.6% | 1,431 | $72,803,000 | $72,841,173 | 7 | Focus Features | - |
| 11 | 11 | - | Paul Blart: Mall Cop | $1,875,000 | $1,842,984 | -$32,016 | -1.7% | 1,762 | $141,084,000 | $141,052,214 | 10 | Sony Pictures Releasing | - |
| 12 | 12 | - | He's Just Not That Into You | $1,270,000 | $1,250,201 | -$19,799 | -1.6% | 1,302 | $91,564,000 | $91,544,583 | 7 | Warner Bros. | - |
| 13 | 13 | - | Confessions of a Shopaholic | $761,000 | $741,893 | -$19,107 | -2.5% | 917 | $42,948,000 | $42,928,251 | 6 | Walt Disney Studios Motion Pictures | - |
| 14 | 15 | +1 | Fired Up! | $750,000 | $701,639 | -$48,361 | -6.4% | 1,209 | $16,803,000 | $16,755,117 | 5 | Screen Gems | - |
| 15 | 14 | -1 | Gran Torino | $735,000 | $740,137 | +$5,137 | +0.7% | 825 | $145,090,000 | $145,095,330 | 15 | Warner Bros. | - |
| 16 | 16 | - | Sunshine Cleaning | $705,000 | $671,618 | -$33,382 | -4.7% | 64 | $994,000 | $960,041 | 2 | Overture Films | - |
| 17 | 17 | - | Miss March | $680,000 | $664,351 | -$15,649 | -2.3% | 1,742 | $4,137,000 | $4,121,295 | 2 | Fox Searchlight Pictures | - |
| 18 | 18 | - | The Reader | $545,000 | $535,983 | -$9,017 | -1.7% | 704 | $32,909,000 | $32,900,557 | 15 | The Weinstein Company | - |
| 19 | 19 | - | Hotel for Dogs | $407,000 | $403,092 | -$3,908 | -1% | 522 | $70,910,000 | $70,906,136 | 10 | DreamWorks | - |
| 20 | 21 | +1 | Under the Sea 3D | $386,000 | $353,634 | -$32,366 | -8.4% | 54 | - | $3,869,888 | 6 | Warner Bros. | - |
| 21 | 20 | -1 | Jonas Brothers: The 3D Concert Experience | $360,000 | $362,694 | +$2,694 | +0.7% | 468 | $19,022,000 | $19,024,826 | 4 | Walt Disney Studios Motion Pictures | - |
| 22 | 22 | - | The Class | $224,000 | $206,232 | -$17,768 | -7.9% | 126 | $2,809,000 | $2,792,008 | 14 | Sony Pictures Classics | - |
| 23 | 24 | +1 | Push | $183,000 | $196,398 | +$13,398 | +7.3% | 290 | $30,978,000 | $30,991,061 | 7 | Summit Entertainment | - |
| 24 | 27 | +3 | The Uninvited | $177,000 | $178,418 | +$1,418 | +0.8% | 282 | $28,435,000 | $28,436,011 | 8 | DreamWorks | - |
| 25 | 29 | +4 | Doubt | $147,000 | $149,360 | +$2,360 | +1.6% | 218 | $33,171,000 | $33,172,718 | 15 | Miramax | - |
| 26 | 33 | +7 | Twilight | $133,000 | $132,914 | -$86 | <0.1% | 247 | $191,368,000 | $191,368,384 | 18 | Summit Entertainment | - |
| 27 | 35 | +8 | The Curious Case of Benjamin Button | $123,000 | $123,045 | +$45 | <0.1% | 206 | $126,759,000 | $126,759,635 | 13 | Paramount Pictures | - |
| 28 | 39 | +11 | Revolutionary Road | $109,000 | $111,319 | +$2,319 | +2.1% | 202 | $22,752,000 | $22,754,434 | 13 | Paramount Vantage | - |
| 29 | 41 | +12 | Sin Nombre | $77,400 | $81,446 | +$4,046 | +5.2% | 6 | $77,400 | $81,446 | 1 | Focus Features | - |
| 30 | 42 | +12 | Milk | $77,300 | $79,518 | +$2,218 | +2.9% | 111 | $31,726,000 | $31,716,847 | 17 | Focus Features | - |
| 31 | 43 | +12 | New in Town | $70,000 | $71,205 | +$1,205 | +1.7% | 158 | $16,698,000 | $16,699,684 | 8 | Lionsgate | - |
| 32 | 45 | +13 | Frost/Nixon | $67,000 | $62,225 | -$4,775 | -7.1% | 131 | $18,597,000 | $18,593,156 | 16 | Universal Pictures | - |
| 33 | 44 | +11 | Defiance | $63,000 | $67,367 | +$4,367 | +6.9% | 118 | $28,387,000 | $28,390,983 | 12 | Paramount Vantage | - |
| 34 | 49 | +15 | Wendy and Lucy | $39,700 | $38,425 | -$1,275 | -3.2% | 40 | $702,000 | $700,720 | 15 | Oscilloscope | - |
| 35 | 51 | +16 | Tokyo! | $34,000 | $36,247 | +$2,247 | +6.6% | 11 | $105,000 | $106,888 | 3 | Liberation Entertainment | - |
| 36 | 58 | +22 | Waltz with Bashir | $32,600 | $24,435 | -$8,165 | -25% | 62 | $2,189,000 | $2,180,986 | 13 | Sony Pictures Classics | - |
| 37 | 54 | +17 | Crossing Over | $31,700 | $34,864 | +$3,164 | +10% | 39 | $344,000 | $347,004 | 4 | The Weinstein Company | - |
| 38 | 57 | +19 | Valkyrie | $25,000 | $25,875 | +$875 | +3.5% | 57 | $83,042,000 | $83,043,123 | 13 | United Artists | - |
| 39 | 60 | +21 | Valentino: The Last Emperor | $20,300 | $21,762 | +$1,462 | +7.2% | 1 | $31,700 | $33,170 | 1 | Truly Indie | - |
| 40 | 69 | +29 | Fanboys | $10,300 | $10,387 | +$87 | +0.8% | 26 | $606,000 | $605,840 | 7 | The Weinstein Company | - |
| 41 | 76 | +35 | Mancora | $5,800 | $7,675 | +$1,875 | +32.3% | 2 | $5,800 | $7,675 | 1 | Maya Entertainment | - |
