| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Confessions of a Shopaholic | $2,056,487 | - | 369 | - | $5,573 | $2,115,992 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | The Curious Case of Benjamin Button | $1,875,214 | -39.1% | 451 | -51 | $4,157 | $11,396,135 | 3 | Warner Bros. | false | false |
| 3 | - | Iago | $1,221,317 | - | 378 | - | $3,230 | $1,226,422 | 1 | Medusa Distribuzione | true | false |
| 4 | - | The Unborn | $982,852 | - | 179 | - | $5,490 | $982,852 | 1 | Universal Pictures International (UPI) | true | false |
| 5 | 15 | Slumdog Millionaire | $862,706 | +557.7% | 159 | +98 | $5,425 | $5,386,228 | 13 | Lucky Red | false | false |
| 6 | 2 | Ex | $806,341 | -46.1% | 236 | -155 | $3,416 | $12,482,618 | 4 | 01 Distribution | false | false |
| 7 | 3 | Inkheart | $799,809 | -32.6% | 249 | -20 | $3,212 | $2,369,069 | 2 | Eagle Pictures | false | false |
| 8 | 6 | The Reader | $670,062 | -2.8% | 161 | - | $4,161 | $1,696,779 | 2 | 01 Distribution | false | false |
| 9 | - | Giulia Doesn't Date at Night | $435,740 | - | 179 | - | $2,434 | $437,061 | 1 | 01 Distribution | true | false |
| 10 | 7 | Underworld: Rise of the Lycans | $374,530 | -39.9% | 119 | - | $3,147 | $1,220,533 | 2 | Sony Pictures Releasing | false | false |
| 11 | 4 | Bride Wars | $344,450 | -60.3% | 223 | -62 | $1,544 | $1,511,891 | 2 | 20th Century Fox International | false | false |
| 12 | 5 | Questo piccolo grande amore | $156,841 | -81.5% | 138 | -281 | $1,136 | $4,595,722 | 3 | Medusa Distribuzione | false | false |
| 13 | - | Impy's Wonderland | $150,000 | - | 143 | - | $1,048 | $150,000 | 1 | Mediafilm | true | false |
| 14 | - | The Wave | $122,314 | - | 57 | - | $2,145 | $122,314 | 1 | BIM Distribuzione | true | false |
| 15 | 16 | Milk | $115,427 | +26.6% | 51 | +7 | $2,263 | $2,849,711 | 6 | BIM Distribuzione | false | false |
| 16 | 10 | Journey to the Center of the Earth | $112,201 | -43.9% | 36 | -45 | $3,116 | $9,904,780 | 7 | 01 Distribution | false | false |
| 17 | 12 | Revolutionary Road | $89,797 | -44.5% | 46 | -42 | $1,952 | $4,390,938 | 5 | Universal Pictures International (UPI) | false | false |
| 18 | - | The Sicilian Girl | $80,570 | - | 53 | - | $1,520 | $80,570 | 1 | Istituto Luce | true | false |
| 19 | 13 | Doubt | $58,887 | -61.9% | 33 | -81 | $1,784 | $2,224,640 | 5 | Walt Disney Pictures | false | false |
| 20 | 9 | Valkyrie | $34,501 | -84.1% | 31 | -95 | $1,112 | $5,711,578 | 5 | 01 Distribution | false | false |
| 21 | 8 | Friday the 13th | $31,736 | -91.3% | 35 | -133 | $906 | $1,559,704 | 3 | Universal Pictures International (UPI) | false | false |
| 22 | 11 | Italians | $30,591 | -83.6% | 22 | -79 | $1,390 | $15,577,295 | 6 | Filmauro | false | false |
| 23 | 17 | I've Loved You So Long | $25,592 | -59.2% | 15 | -22 | $1,706 | $464,884 | 4 | Mikado Film | false | false |
| 24 | 20 | Frost/Nixon | $22,974 | -53.1% | 10 | -17 | $2,297 | $806,772 | 4 | Universal Pictures International (UPI) | false | false |
| 25 | 21 | Hotel for Dogs | $20,464 | -54.7% | 39 | -10 | $524 | $84,355 | 2 | Universal Pictures International (UPI) | false | false |
| 26 | 22 | Easy Virtue | $20,453 | -52.1% | 12 | -6 | $1,704 | $3,073,184 | 8 | Eagle Pictures | false | false |
| 27 | 18 | Beverly Hills Chihuahua | $18,867 | -62.9% | 26 | -69 | $725 | $4,935,387 | 7 | Walt Disney Pictures | false | false |
| 28 | 14 | Eagle Eye | $17,909 | -86.9% | 10 | -41 | $1,790 | $198,970 | 2 | Universal Pictures International (UPI) | false | false |
| 29 | 27 | Márió, a varázsló | $13,242 | -34.6% | 3 | -1 | $4,414 | $141,971 | 14 | L'Altrofilm | false | false |
| 30 | 25 | Waltz with Bashir | $11,948 | -55.3% | 9 | -13 | $1,327 | $959,524 | 8 | Lucky Red | false | false |
| 31 | 24 | Empties | $11,453 | -62.5% | 6 | -12 | $1,908 | $360,661 | 7 | Fandango | false | false |
| 32 | 30 | Australia | $10,860 | -18% | 7 | -8 | $1,551 | $6,525,726 | 7 | 20th Century Fox International | false | false |
| 33 | 28 | Religulous | $10,263 | -46.2% | 6 | -1 | $1,710 | $95,638 | 3 | Eagle Pictures | false | false |
| 34 | 19 | Space Chimps | $9,760 | -80.1% | 20 | -81 | $488 | $706,297 | 4 | Medusa Distribuzione | false | false |
| 35 | 34 | The Boy in the Striped Pajamas | $9,332 | +10.3% | 14 | +4 | $666 | $3,363,993 | 11 | Walt Disney Pictures | false | false |
| 36 | 36 | The Visitor | $6,521 | -19.6% | 4 | -1 | $1,630 | $1,817,508 | 13 | Bolero Film | false | false |
| 37 | 23 | Waiting for the sun | $5,846 | -83.4% | 9 | -34 | $649 | $54,505 | 2 | Mikado Film | false | false |
| 38 | 35 | Lemon Tree | $5,182 | -36.9% | 3 | -2 | $1,727 | $1,311,627 | 12 | Teodora Film | false | false |
| 39 | 38 | Appaloosa | $4,575 | -16.2% | 3 | -1 | $1,525 | $374,980 | 7 | 01 Distribution | false | false |
| 40 | 32 | Katyn | $4,542 | -58.6% | 5 | -6 | $908 | $35,906 | 3 | N/A | false | false |
| 41 | 33 | Home | $4,464 | -51.1% | 4 | -3 | $1,116 | $159,990 | 5 | Teodora Film | false | false |
| 42 | 29 | Mar nero | $4,092 | -71.4% | 4 | -6 | $1,023 | $89,680 | 5 | N/A | false | false |
| 43 | - | In the Name of the King: A Dungeon Siege Tale | $3,677 | - | 3 | - | $1,225 | $3,677 | 1 | One Movie | true | false |
| 44 | - | Giovanna's Father | $3,456 | - | 1 | - | $3,456 | $4,861,031 | 25 | Medusa Distribuzione | false | false |
| 45 | - | The Dark Knight | $2,985 | - | 7 | - | $426 | $13,871,401 | 32 | Warner Bros. | false | false |
| 46 | 26 | Yes Man | $2,791 | -88.4% | 4 | -12 | $697 | $10,187,158 | 8 | Warner Bros. | false | false |
| 47 | 37 | Seven Pounds | $2,498 | -55.9% | 7 | +1 | $356 | $16,021,697 | 8 | Sony Pictures Releasing | false | false |
| 48 | 39 | Let the Right One In | $2,454 | -41.5% | 2 | -2 | $1,227 | $647,112 | 8 | Bolero Film | false | false |
| 49 | - | Puccini and the Girl | $2,334 | - | 1 | - | $2,334 | $2,334 | 1 | N/A | true | false |
| 50 | 44 | We Can Do That | $2,235 | +79.5% | 5 | +2 | $447 | $2,375,993 | 18 | Warner Bros. | false | false |
| 51 | - | Gomorrah | $1,717 | - | 1 | - | $1,717 | $17,665,830 | 42 | 01 Distribution | false | false |
