| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Slumdog Millionaire | $2,256,473 | +72.6% | 250 | +51 | $9,025 | $6,127,851 | 3 | Filmax | false | false |
| 2 | - | The Pink Panther 2 | $2,001,555 | - | 397 | - | $5,041 | $2,001,555 | 1 | Sony Pictures Releasing | true | false |
| 3 | 1 | The Curious Case of Benjamin Button | $1,390,200 | -27.8% | 449 | -12 | $3,096 | $13,610,867 | 4 | Warner Bros. | false | false |
| 4 | 5 | The Reader | $894,079 | -3.2% | 210 | - | $4,257 | $3,560,517 | 3 | On Pictures | false | false |
| 5 | 4 | Beverly Hills Chihuahua | $875,231 | -10.9% | 300 | - | $2,917 | $6,678,269 | 4 | Walt Disney Pictures | false | false |
| 6 | 3 | Push | $777,492 | -30.8% | 276 | - | $2,817 | $2,186,305 | 2 | - | false | false |
| 7 | - | In the Name of the King: A Dungeon Siege Tale | $678,818 | - | 218 | - | $3,113 | $678,818 | 1 | New World Pictures | true | false |
| 8 | - | Che: Part Two | $496,885 | - | 249 | - | $1,995 | $496,885 | 1 | 20th Century Fox International | true | false |
| 9 | 7 | The Wrestler | $247,538 | -46.2% | 155 | - | $1,597 | $836,752 | 2 | United International Pictures | false | false |
| 10 | 6 | Valkyrie | $235,819 | -50.4% | 249 | -115 | $947 | $7,560,684 | 5 | 20th Century Fox International | false | false |
| 11 | 9 | Seven Pounds | $230,587 | -35.7% | 223 | -68 | $1,034 | $13,216,892 | 7 | Sony Pictures Releasing | false | false |
| 12 | 10 | Doubt | $218,955 | -17% | 125 | -7 | $1,751 | $2,935,815 | 5 | Walt Disney Pictures | false | false |
| 13 | 8 | Friday the 13th | $204,931 | -45.8% | 207 | -23 | $990 | $1,736,857 | 3 | Paramount Pictures International | false | false |
| 14 | 12 | Welcome to the Sticks | $124,432 | -30.3% | 109 | -29 | $1,141 | $4,167,702 | 8 | Wanda Visión S.A. | false | false |
| 15 | 11 | Revolutionary Road | $116,402 | -48.4% | 125 | -126 | $931 | $5,172,343 | 6 | Paramount Pictures International | false | false |
| 16 | 25 | Milk | $83,899 | +223% | 99 | +19 | $847 | $1,639,103 | 8 | United International Pictures | false | false |
| 17 | - | Ghost Town | $81,026 | - | 60 | - | $1,350 | $81,029 | 1 | Paramount Pictures International | true | false |
| 18 | - | Let it Rain | $68,154 | - | 29 | - | $2,350 | $68,154 | 1 | - | true | false |
| 19 | 16 | The Class | $58,568 | -24.2% | 53 | -12 | $1,105 | $1,513,946 | 7 | Golem Distribución | false | false |
| 20 | 23 | Bolt | $42,382 | +6.4% | 58 | -34 | $730 | $10,507,078 | 13 | Walt Disney Pictures | false | false |
| 21 | 20 | The Milk of Sorrow | $38,430 | -25.3% | 26 | -3 | $1,478 | $146,259 | 3 | Wanda Visión S.A. | false | false |
| 22 | 19 | Waltz with Bashir | $38,233 | -31.1% | 31 | -3 | $1,233 | $1,203,156 | 2 | Golem Distribución | false | false |
| 23 | - | Julia | $37,741 | - | 30 | - | $1,258 | $37,741 | 1 | Vértigo Films | true | false |
| 24 | 40 | Vicky Cristina Barcelona | $36,899 | +373.5% | 49 | +28 | $753 | $9,842,526 | 24 | Warner Bros. | false | false |
| 25 | 24 | The Missing Lynx | $36,201 | +28.1% | 58 | -27 | $624 | $1,443,084 | 10 | - | false | false |
| 26 | 14 | Mediterranean Food | $32,070 | -61.4% | 47 | -87 | $682 | $811,820 | 4 | Alta Films | false | false |
| 27 | 13 | Transporter 3 | $31,967 | -64.4% | 60 | -87 | $532 | $3,591,848 | 6 | DeAPlaneta | false | false |
| 28 | 15 | Role Models | $28,633 | -63.8% | 57 | -82 | $502 | $1,692,311 | 5 | Universal Pictures International (UPI) | false | false |
| 29 | 18 | The Way | $24,084 | -60.4% | 37 | -61 | $650 | $2,165,960 | 20 | Alta Films | false | false |
| 30 | 17 | Bride Wars | $23,527 | -61.6% | 52 | -73 | $452 | $3,308,870 | 7 | 20th Century Fox International | false | false |
| 31 | 21 | Australia | $23,522 | -51.8% | 36 | -39 | $653 | $14,442,004 | 10 | 20th Century Fox International | false | false |
| 32 | 31 | Madagascar: Escape 2 Africa | $13,644 | -13.6% | 39 | -27 | $349 | $20,012,631 | 14 | Paramount Pictures International | false | false |
| 33 | 22 | Frost/Nixon | $13,496 | -68.9% | 24 | -52 | $562 | $424,010 | 4 | Universal Pictures International (UPI) | false | false |
| 34 | 34 | El Zorro de San Adrian | $12,915 | +16.5% | 14 | -1 | $922 | $76,269 | 4 | Barton Films | false | false |
| 35 | 33 | The Tale of Despereaux | $12,635 | -2.7% | 23 | -14 | $549 | $3,814,617 | 11 | Universal Pictures International (UPI) | false | false |
| 36 | 28 | The Hanged Man | $9,941 | -55.9% | 16 | -37 | $621 | $424,488 | 5 | Sony Pictures Releasing | false | false |
| 37 | - | The Broken | $9,815 | - | 9 | - | $1,090 | $9,815 | 1 | Independent Films | true | false |
| 38 | 37 | El libro de las aguas | $9,225 | +3.5% | 6 | +1 | $1,537 | $141,958 | 16 | Independent Films | false | false |
| 39 | 26 | Big Stan | $7,723 | -68.9% | 20 | -41 | $386 | $1,445,767 | 6 | - | false | false |
| 40 | 27 | The Unborn | $7,641 | -66.7% | 26 | -42 | $293 | $3,390,575 | 7 | Universal Pictures International (UPI) | false | false |
| 41 | 30 | Changeling | $7,376 | -62.3% | 13 | -42 | $567 | $10,932,126 | 11 | Universal Pictures International (UPI) | false | false |
| 42 | 42 | In Search of a Midnight Kiss | $5,827 | +10.1% | 3 | -1 | $1,942 | $431,072 | 13 | Sherlock Films | false | false |
| 43 | 46 | El ratón Pérez 2 | $5,598 | +30.3% | 10 | -9 | $559 | $1,140,470 | 12 | Filmax | false | false |
| 44 | 38 | Twilight | $5,330 | -39.9% | 17 | -6 | $313 | $16,160,531 | 13 | - | false | false |
| 45 | 29 | Cadillac Records | $5,285 | -74.1% | 15 | -15 | $352 | $35,253 | 2 | Sony Pictures Releasing | false | false |
| 46 | 44 | Winx Club: The Secret of the Lost Kingdom | $4,226 | -7.9% | 18 | -6 | $234 | $467,399 | 11 | Filmax | false | false |
| 47 | 35 | The Secret of the Grain | $3,680 | -64.5% | 5 | -6 | $736 | $188,687 | 5 | Vértigo Films | false | false |
| 48 | 32 | The One-Handed Trick | $3,289 | -78.5% | 8 | -17 | $411 | $497,308 | 7 | Alta Films | false | false |
| 49 | - | The Last Deadly Mission | $3,134 | - | 8 | - | $391 | $3,134 | 1 | Versus Entertainment | true | false |
| 50 | 36 | Easy Virtue | $2,400 | -74.1% | 3 | -7 | $800 | $1,904,205 | 9 | DeAPlaneta | false | false |
| 51 | 47 | Yes Man | $2,010 | -37.2% | 8 | -1 | $251 | $6,098,000 | 11 | Warner Bros. | false | false |
| 52 | 50 | My Blueberry Nights | $1,982 | -3.6% | 2 | - | $991 | $1,158,822 | 12 | Vértigo Films | false | false |
| 53 | 39 | The Wave | $1,540 | -82% | 6 | -11 | $256 | $1,708,134 | 14 | - | false | false |
| 54 | 48 | City of Ember | $1,465 | -54.2% | 9 | -6 | $162 | $1,595,399 | 9 | N/A | false | false |
| 55 | 53 | Gomorrah | $1,259 | +33.2% | 6 | - | $209 | $3,280,410 | 16 | Alta Films | false | false |
| 56 | 51 | Rachel Getting Married | $962 | -21.4% | 2 | -1 | $481 | $283,109 | 18 | Sony Pictures Releasing | false | false |
| 57 | 41 | Forever Waiting | $878 | -88% | 7 | -19 | $125 | $11,893 | 2 | Barton Films | false | false |
| 58 | 60 | The Anarchist's Wife | $735 | +116.8% | 1 | - | $735 | $253,484 | 6 | Alta Films | false | false |
| 59 | 43 | A Complete History of My Sexual Failures | $583 | -88.3% | 5 | -12 | $116 | $43,338 | 3 | Avalon | false | false |
| 60 | 54 | Quarantine | $579 | -33.3% | 2 | -1 | $289 | $1,268,045 | 8 | Filmax | false | false |
| 61 | 52 | RocknRolla | $551 | -46.6% | 6 | - | $91 | $1,382,975 | 9 | Warner Bros. | false | false |
| 62 | 45 | Defiance | $534 | -87.7% | 2 | -12 | $267 | $3,260,190 | 8 | - | false | false |
| 63 | 57 | Il Divo | $392 | -40.2% | 1 | -1 | $392 | $352,198 | 12 | Wanda Visión S.A. | false | false |
| 64 | 59 | Lemon Tree | $380 | -8.2% | 2 | - | $190 | $548,354 | 22 | Golem Distribución | false | false |
| 65 | 49 | Nick and Norah's Infinite Playlist | $230 | -90.1% | 2 | -13 | $115 | $25,189 | 3 | Sony Pictures Releasing | false | false |
| 66 | 62 | Lissi und der wilde Kaiser | $99 | -66.4% | 1 | -1 | $99 | $922,955 | 12 | Warner Bros. | false | false |
| 67 | 65 | Estomago: A Gastronomic Story | $46 | -61.3% | 1 | - | $46 | $262,827 | 11 | Alta Films | false | false |
| 68 | 55 | Pride and Glory | $17 | -97.8% | 1 | -2 | $17 | $3,501,092 | 9 | TriPictures | false | false |
