| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Bedtime Stories | $379,182 | +1.2% | 59 | - | $6,426 | $1,253,231 | 2 | Walt Disney Pictures | false | false |
| 2 | - | Valkyrie | $266,077 | - | 60 | - | $4,434 | $294,748 | 1 | N/A | true | false |
| 3 | 3 | The Curious Case of Benjamin Button | $188,381 | +3.3% | 38 | -2 | $4,957 | $1,043,662 | 3 | N/A | false | false |
| 4 | - | The Pink Panther 2 | $182,248 | - | 46 | - | $3,961 | $182,248 | 1 | Sony Pictures Releasing | true | false |
| 5 | 2 | Yes Man | $168,699 | -24.9% | 52 | -3 | $3,244 | $2,708,403 | 5 | Warner Bros. | false | false |
| 6 | 4 | Friday the 13th | $98,606 | -30.6% | 40 | +2 | $2,465 | $367,922 | 2 | N/A | false | false |
| 7 | 5 | Bride Wars | $79,091 | -42.6% | 27 | -12 | $2,929 | $737,155 | 3 | N/A | false | false |
| 8 | - | Wild Child | $50,342 | - | 20 | - | $2,517 | $50,342 | 1 | N/A | true | false |
| 9 | 7 | Over Her Dead Body | $34,620 | -42.4% | 19 | - | $1,822 | $134,617 | 2 | N/A | false | false |
| 10 | 9 | Vicky Cristina Barcelona | $30,631 | +7% | 7 | -1 | $4,375 | $86,912 | 2 | N/A | false | false |
| 11 | 6 | Hotel for Dogs | $27,870 | -54.2% | 27 | -13 | $1,032 | $1,061,284 | 5 | N/A | false | false |
| 12 | 8 | Seven Pounds | $13,982 | -75.7% | 12 | -15 | $1,165 | $1,274,854 | 6 | N/A | false | false |
| 13 | 11 | Changeling | $7,110 | -59.2% | 3 | -11 | $2,370 | $315,302 | 5 | N/A | false | false |
| 14 | 10 | The Spirit | $4,344 | -75.6% | 10 | -12 | $434 | $135,328 | 3 | N/A | false | false |
| 15 | 13 | Revolutionary Road | $3,764 | -73.1% | 8 | -7 | $470 | $216,357 | 4 | N/A | false | false |
| 16 | 15 | The Marsh | $3,739 | -63.2% | 4 | -3 | $934 | $336,655 | 7 | N/A | false | false |
| 17 | 12 | Marley & Me | $2,450 | -83.5% | 3 | -12 | $816 | $1,126,566 | 6 | N/A | false | false |
| 18 | 20 | Bolt | $2,210 | -58.1% | 6 | -11 | $368 | $2,236,184 | 10 | N/A | false | false |
| 19 | 14 | Mad Money | $1,753 | -85.2% | 6 | -1 | $292 | $190,288 | 4 | N/A | false | false |
| 20 | 19 | Twilight | $1,008 | -82.8% | 2 | -3 | $504 | $2,764,194 | 10 | N/A | false | false |
| 21 | 21 | Lonely Hearts | $733 | -80.3% | 2 | -5 | $366 | $109,520 | 4 | N/A | false | false |
| 22 | 22 | Madagascar: Escape 2 Africa | $700 | -68.4% | 3 | -6 | $233 | $5,444,477 | 11 | N/A | false | false |
| 23 | 16 | Quarantine | $335 | -96.2% | 2 | -10 | $167 | $268,301 | 5 | N/A | false | false |
