| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Curious Case of Benjamin Button | $355,098 | -51% | - | - | - | $1,708,101 | 2 | Warner Bros. | false | false |
| 2 | - | Marley & Me | $205,165 | - | - | - | - | $411,905 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | He's Just Not That Into You | $169,163 | -53.1% | - | - | - | $900,269 | 2 | ARM Distribution | false | false |
| 4 | - | Coming Soon | $161,040 | - | - | - | - | $229,259 | 1 | N/A | true | false |
| 5 | 3 | Valkyrie | $107,297 | -60.4% | - | - | - | $600,674 | 2 | 20th Century Fox International | false | false |
| 6 | - | The International | $80,378 | - | - | - | - | $101,230 | 1 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | true | false |
| 7 | - | Confessions of a Shopaholic | $59,253 | - | - | - | - | $77,541 | - | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | - | false |
| 8 | - | Milk | $24,394 | - | - | - | - | $24,394 | 1 | N/A | true | false |
| 9 | 4 | Yes Man | $23,097 | -84% | - | - | - | $2,920,409 | 5 | Warner Bros. | false | false |
| 10 | 7 | Revolutionary Road | $9,430 | -79.7% | - | - | - | $412,278 | 3 | United International Pictures | false | false |
| 11 | - | The Wrestler | $8,214 | - | - | - | - | $10,100 | 1 | N/A | true | false |
| 12 | 6 | Seven Pounds | $7,532 | -88.6% | - | - | - | $432,512 | 3 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | false | false |
| 13 | - | Doubt | $6,841 | - | - | - | - | $8,680 | 1 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | true | false |
| 14 | - | The Class | $5,426 | - | - | - | - | $6,672 | 1 | N/A | true | false |
| 15 | 8 | Red Cliff II | $4,560 | -90.1% | - | - | - | $4,491,399 | 6 | 20th Century Fox International | false | false |
| 16 | 9 | Madagascar: Escape 2 Africa | $4,201 | -82.9% | - | - | - | $1,509,391 | 5 | United International Pictures | false | false |
| 17 | 13 | Frost/Nixon | $2,669 | -70.6% | - | - | - | $17,404 | 2 | United International Pictures | false | false |
| 18 | 16 | Elsa & Fred | $1,322 | -58.2% | - | - | - | $7,657 | 2 | N/A | false | false |
| 19 | 14 | Detroit Metal City | $770 | -86.5% | - | - | - | $403,564 | 6 | N/A | false | false |
| 20 | 12 | Ponyo | $690 | -95% | - | - | - | $1,072,756 | 5 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | false | false |
| 21 | 19 | Man on Wire | $591 | +20.9% | - | - | - | $5,956 | 3 | N/A | false | false |
| 22 | 11 | Bride Wars | $464 | -96.7% | - | - | - | $1,186,291 | 5 | 20th Century Fox International | false | false |
| 23 | 15 | Naruto Shippuden: The Movie - Bonds | $353 | -92.1% | - | - | - | $226,585 | 4 | N/A | false | false |
| 24 | 10 | Inkheart | $201 | -99.1% | - | - | - | $1,815,019 | 5 | ARM Distribution | false | false |
