| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Curious Case of Benjamin Button | $3,077,168 | -20.5% | 502 | +25 | $6,129 | $8,581,923 | 2 | Warner Bros. | false | false |
| 2 | 2 | Ex | $1,495,666 | -48% | 391 | -180 | $3,825 | $11,339,653 | 3 | 01 Distribution | false | false |
| 3 | - | Inkheart | $1,186,936 | - | 269 | - | $4,412 | $1,187,820 | 1 | Eagle Pictures | true | false |
| 4 | - | Bride Wars | $867,124 | - | 285 | - | $3,042 | $868,447 | 1 | 20th Century Fox International | true | false |
| 5 | 3 | Questo piccolo grande amore | $845,507 | -64.6% | 419 | -48 | $2,017 | $4,246,415 | 2 | Medusa Distribuzione | false | false |
| 6 | - | The Reader | $689,170 | - | 161 | - | $4,280 | $689,815 | 1 | 01 Distribution | true | false |
| 7 | - | Underworld: Rise of the Lycans | $623,409 | - | 119 | - | $5,238 | $625,097 | 1 | Sony Pictures Releasing | true | false |
| 8 | 4 | Friday the 13th | $363,312 | -56.2% | 168 | -30 | $2,162 | $1,439,235 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | 6 | Valkyrie | $216,947 | -61.7% | 126 | -115 | $1,721 | $5,671,571 | 4 | 01 Distribution | false | false |
| 10 | 7 | Journey to the Center of the Earth | $199,863 | -56.1% | 81 | -61 | $2,467 | $9,838,715 | 6 | 01 Distribution | false | false |
| 11 | 5 | Italians | $186,674 | -69.6% | 101 | -140 | $1,848 | $15,467,736 | 5 | Filmauro | false | false |
| 12 | 8 | Revolutionary Road | $161,698 | -63.3% | 88 | -118 | $1,837 | $4,283,772 | 4 | Universal Pictures International (UPI) | false | false |
| 13 | 9 | Doubt | $154,707 | -38.5% | 114 | -31 | $1,357 | $2,129,664 | 4 | Walt Disney Pictures | false | false |
| 14 | - | Eagle Eye | $136,980 | - | 51 | - | $2,685 | $137,379 | 1 | Universal Pictures International (UPI) | true | false |
| 15 | 16 | Slumdog Millionaire | $131,162 | +26.2% | 61 | +15 | $2,150 | $4,352,770 | 12 | Lucky Red | false | false |
| 16 | 13 | Milk | $91,205 | -36.4% | 44 | -23 | $2,072 | $2,703,595 | 5 | BIM Distribuzione | false | false |
| 17 | 15 | I've Loved You So Long | $62,672 | -44.7% | 37 | -17 | $1,693 | $410,969 | 3 | Mikado Film | false | false |
| 18 | 12 | Beverly Hills Chihuahua | $50,853 | -64.9% | 95 | -49 | $535 | $4,895,349 | 6 | Walt Disney Pictures | false | false |
| 19 | 10 | Space Chimps | $48,972 | -70.2% | 101 | -56 | $484 | $681,280 | 3 | Medusa Distribuzione | false | false |
| 20 | 14 | Frost/Nixon | $48,952 | -64.5% | 27 | -100 | $1,813 | $760,497 | 3 | Universal Pictures International (UPI) | false | false |
| 21 | - | Hotel for Dogs | $45,213 | - | 49 | - | $922 | $45,317 | 1 | Universal Pictures International (UPI) | true | false |
| 22 | 18 | Easy Virtue | $42,711 | -31.2% | 18 | -8 | $2,372 | $3,027,006 | 7 | Eagle Pictures | false | false |
| 23 | - | Waiting for the sun | $35,211 | - | 43 | - | $818 | $35,211 | 1 | Mikado Film | true | false |
| 24 | 21 | Empties | $30,542 | -4.7% | 18 | - | $1,696 | $337,474 | 6 | Fandango | false | false |
| 25 | 23 | Waltz with Bashir | $26,739 | -4.8% | 22 | +2 | $1,215 | $931,596 | 7 | Lucky Red | false | false |
| 26 | 17 | Yes Man | $24,088 | -74.5% | 16 | -23 | $1,505 | $10,301,767 | 7 | Warner Bros. | false | false |
| 27 | - | Márió, a varázsló | $20,245 | - | 4 | - | $5,061 | $120,546 | 13 | L'Altrofilm | false | false |
| 28 | 20 | Religulous | $19,081 | -48% | 7 | -15 | $2,725 | $74,710 | 2 | Eagle Pictures | false | false |
| 29 | 27 | Mar nero | $14,295 | +0.7% | 10 | +3 | $1,429 | $81,035 | 4 | N/A | false | false |
| 30 | 19 | Australia | $13,247 | -76.1% | 15 | -16 | $883 | $6,499,040 | 6 | 20th Century Fox International | false | false |
| 31 | 11 | Horsemen | $12,714 | -91.9% | 8 | -106 | $1,589 | $941,773 | 3 | Moviemax | false | false |
| 32 | 30 | Katyn | $10,982 | +9.5% | 11 | +3 | $998 | $26,646 | 2 | N/A | false | false |
| 33 | 24 | Home | $9,137 | -55.6% | 7 | -10 | $1,305 | $151,540 | 4 | Teodora Film | false | false |
| 34 | 32 | The Boy in the Striped Pajamas | $8,457 | +25.9% | 10 | - | $845 | $3,332,726 | 10 | Walt Disney Pictures | false | false |
| 35 | 26 | Lemon Tree | $8,206 | -48.4% | 5 | -4 | $1,641 | $1,311,260 | 11 | Teodora Film | false | false |
| 36 | 25 | The Visitor | $8,109 | -50% | 5 | -3 | $1,621 | $1,822,343 | 12 | Bolero Film | false | false |
| 37 | 22 | Seven Pounds | $5,670 | -80% | 6 | -10 | $945 | $14,404,170 | 7 | Sony Pictures Releasing | false | false |
| 38 | 31 | Appaloosa | $5,457 | -37.1% | 4 | -2 | $1,364 | $343,549 | 6 | 01 Distribution | false | false |
| 39 | 41 | Let the Right One In | $4,194 | +78.5% | 4 | +2 | $1,048 | $650,374 | 7 | Bolero Film | false | false |
| 40 | 34 | Madagascar: Escape 2 Africa | $3,444 | -27.7% | 6 | -8 | $574 | $34,915,869 | 10 | Universal Pictures International (UPI) | false | false |
| 41 | 42 | WALL·E | $3,158 | +34.8% | 3 | -3 | $1,052 | $12,210,993 | 19 | Walt Disney Pictures | false | false |
| 42 | 37 | Tony Manero | $2,923 | -20% | 3 | -3 | $974 | $171,645 | 6 | Ripley's Film | false | false |
| 43 | - | Maria Venera | $2,608 | - | 4 | - | $652 | $2,608 | 1 | N/A | true | false |
| 44 | 35 | We Can Do That | $1,245 | -73.2% | 3 | -2 | $415 | $2,371,568 | 17 | Warner Bros. | false | false |
| 45 | - | Lissi und der wilde Kaiser | $1,216 | - | 2 | - | $608 | $597,954 | 8 | Moviemax | false | false |
| 46 | 39 | Bolt | $1,125 | -57.1% | 3 | -4 | $375 | $7,410,399 | 13 | Walt Disney Pictures | false | false |
| 47 | 28 | Beket | $1,103 | -91.2% | 1 | -1 | $1,103 | $6,482 | 5 | N/A | false | false |
| 48 | 44 | Defiance | $951 | -9.9% | 2 | -3 | $475 | $1,142,546 | 5 | Medusa Distribuzione | false | false |
| 49 | - | Charlotte's Web | $889 | - | 1 | - | $889 | $86,446 | 103 | Universal Pictures International (UPI) | false | false |
| 50 | - | Comme les autres | $719 | - | 2 | - | $359 | $194,742 | 10 | Archibald | false | false |
| 51 | 29 | Nick and Norah's Infinite Playlist | $446 | -96.1% | 2 | -9 | $223 | $15,228 | 2 | Sony Pictures Releasing | false | false |
| 52 | 51 | Quarantine | $253 | +31.1% | 3 | +2 | $84 | $63,140 | 4 | Sony Pictures Releasing | false | false |
