| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Curious Case of Benjamin Button | $3,120,218 | -37.8% | 461 | +2 | $6,768 | $9,251,220 | 2 | Warner Bros. | false | false |
| 2 | 2 | Beverly Hills Chihuahua | $1,727,348 | -27.7% | 300 | - | $5,757 | $4,341,355 | 2 | Walt Disney Pictures | false | false |
| 3 | - | Slumdog Millionaire | $1,302,275 | - | 177 | - | $7,357 | $1,311,465 | 1 | Filmax | true | false |
| 4 | - | The Reader | $1,057,541 | - | 209 | - | $5,060 | $1,057,541 | 1 | On Pictures | true | false |
| 5 | - | Friday the 13th | $949,732 | - | 230 | - | $4,129 | $949,732 | 1 | Paramount Pictures International | true | false |
| 6 | 3 | Valkyrie | $889,039 | -47.6% | 380 | -17 | $2,339 | $6,533,846 | 3 | 20th Century Fox International | false | false |
| 7 | 4 | Seven Pounds | $638,509 | -35.4% | 309 | -2 | $2,066 | $12,426,410 | 5 | Sony Pictures Releasing | false | false |
| 8 | 5 | Doubt | $357,789 | -40.6% | 132 | +4 | $2,710 | $2,239,988 | 3 | Walt Disney Pictures | false | false |
| 9 | 6 | Revolutionary Road | $333,490 | -42.3% | 256 | -5 | $1,302 | $4,652,462 | 4 | Paramount Pictures International | false | false |
| 10 | 9 | Welcome to the Sticks | $247,777 | -29.3% | 150 | -1 | $1,651 | $3,728,951 | 6 | Wanda Visión S.A. | false | false |
| 11 | 8 | Transporter 3 | $214,855 | -42.8% | 202 | -51 | $1,063 | $3,416,921 | 4 | DeAPlaneta | false | false |
| 12 | 7 | Role Models | $200,802 | -51.4% | 180 | -39 | $1,115 | $1,538,740 | 3 | Universal Pictures International (UPI) | false | false |
| 13 | 10 | Mediterranean Food | $186,734 | -44.6% | 201 | -5 | $929 | $619,655 | 2 | Alta Films | false | false |
| 14 | 12 | The Way | $125,428 | -28.3% | 128 | +4 | $979 | $2,006,628 | 18 | Alta Films | false | false |
| 15 | 11 | Bride Wars | $113,960 | -50.4% | 175 | -73 | $651 | $3,188,509 | 5 | 20th Century Fox International | false | false |
| 16 | 16 | The Class | $93,427 | -35.8% | 62 | -1 | $1,506 | $1,312,305 | 5 | Golem Distribución | false | false |
| 17 | 14 | Australia | $83,042 | -47.8% | 103 | -81 | $806 | $14,340,708 | 8 | 20th Century Fox International | false | false |
| 18 | 13 | Frost/Nixon | $82,923 | -51.7% | 86 | -1 | $964 | $314,874 | 2 | Universal Pictures International (UPI) | false | false |
| 19 | 17 | Big Stan | $60,290 | -51.2% | 98 | -55 | $615 | $1,395,028 | 4 | - | false | false |
| 20 | 19 | Bolt | $54,153 | -38.4% | 114 | -38 | $475 | $10,412,184 | 11 | Walt Disney Pictures | false | false |
| 21 | 15 | The Unborn | $51,531 | -65.9% | 82 | -66 | $628 | $3,388,421 | 5 | Universal Pictures International (UPI) | false | false |
| 22 | 23 | The Missing Lynx | $39,006 | -17.2% | 91 | -10 | $428 | $1,373,780 | 8 | - | false | false |
| 23 | 21 | Milk | $36,077 | -38.2% | 74 | -7 | $487 | $1,491,923 | 6 | United International Pictures | false | false |
| 24 | 18 | Changeling | $35,720 | -59.6% | 69 | -51 | $517 | $10,881,055 | 9 | Universal Pictures International (UPI) | false | false |
| 25 | 20 | The Hanged Man | $32,738 | -59.6% | 107 | -11 | $305 | $378,977 | 3 | Sony Pictures Releasing | false | false |
| 26 | 22 | The One-Handed Trick | $29,635 | -43.9% | 39 | -17 | $759 | $466,011 | 5 | Alta Films | false | false |
| 27 | - | A Complete History of My Sexual Failures | $25,175 | - | 34 | - | $740 | $25,175 | 1 | Avalon | true | false |
| 28 | 24 | Madagascar: Escape 2 Africa | $24,622 | -47.2% | 77 | -31 | $319 | $19,975,673 | 12 | Paramount Pictures International | false | false |
| 29 | - | The Milk of Sorrow | $19,273 | - | 9 | - | $2,141 | $19,273 | 1 | Wanda Visión S.A. | true | false |
| 30 | 25 | The Secret of the Grain | $17,700 | -58.8% | 17 | -7 | $1,041 | $163,792 | 3 | Vértigo Films | false | false |
| 31 | - | Nick and Norah's Infinite Playlist | $17,427 | - | 30 | - | $580 | $17,427 | 1 | Sony Pictures Releasing | true | false |
| 32 | 28 | Easy Virtue | $16,946 | -34.4% | 14 | -4 | $1,210 | $1,882,969 | 7 | DeAPlaneta | false | false |
| 33 | 26 | The Tale of Despereaux | $15,828 | -57.7% | 57 | -24 | $277 | $3,782,851 | 9 | Universal Pictures International (UPI) | false | false |
| 34 | 29 | Twilight | $15,733 | -30.2% | 33 | -12 | $476 | $16,136,923 | 11 | - | false | false |
| 35 | 27 | Defiance | $15,507 | -50.1% | 30 | -30 | $516 | $3,249,400 | 6 | - | false | false |
| 36 | 31 | El Zorro de San Adrian | $13,695 | -2.6% | 15 | +2 | $913 | $35,232 | 2 | Barton Films | false | false |
| 37 | 37 | El libro de las aguas | $9,601 | +1.6% | 5 | - | $1,920 | $122,169 | 14 | Independent Films | false | false |
| 38 | 30 | The Wave | $9,139 | -56.1% | 19 | -7 | $481 | $1,691,174 | 12 | - | false | false |
| 39 | 32 | In Search of a Midnight Kiss | $8,224 | -41.3% | 6 | -2 | $1,370 | $413,374 | 11 | Sherlock Films | false | false |
| 40 | 35 | City of Ember | $7,453 | -33.3% | 20 | -15 | $372 | $1,488,537 | 7 | N/A | false | false |
| 41 | 36 | El ratón Pérez 2 | $6,844 | -29.4% | 20 | -27 | $342 | $1,128,736 | 10 | Filmax | false | false |
| 42 | 34 | Vicky Cristina Barcelona | $6,329 | -48.1% | 18 | -8 | $351 | $9,789,307 | 22 | Warner Bros. | false | false |
| 43 | 38 | My Blueberry Nights | $5,596 | -19.7% | 5 | -1 | $1,119 | $1,149,849 | 10 | Vértigo Films | false | false |
| 44 | 33 | Yes Man | $5,164 | -62.3% | 18 | -14 | $286 | $6,090,573 | 9 | Warner Bros. | false | false |
| 45 | 39 | Winx Club: The Secret of the Lost Kingdom | $3,181 | -42% | 21 | -12 | $151 | $456,828 | 9 | Filmax | false | false |
| 46 | 40 | RocknRolla | $3,070 | -35.8% | 7 | -8 | $438 | $1,380,155 | 7 | Warner Bros. | false | false |
| 47 | 47 | Pride and Glory | $3,049 | +10.1% | 7 | -5 | $435 | $3,498,529 | 7 | TriPictures | false | false |
| 48 | 49 | Rachel Getting Married | $1,614 | -35.5% | 3 | +1 | $538 | $278,479 | 16 | Sony Pictures Releasing | false | false |
| 49 | 42 | Mejor que nunca | $1,401 | -68.2% | 2 | -1 | $700 | $20,773 | 3 | - | false | false |
| 50 | 45 | Il Divo | $1,399 | -57% | 3 | -2 | $466 | $350,347 | 10 | Wanda Visión S.A. | false | false |
| 51 | 41 | Gomorrah | $1,395 | -68.7% | 8 | -1 | $174 | $3,004,266 | 14 | Alta Films | false | false |
| 52 | 44 | The Anarchist's Wife | $1,283 | -61.1% | 13 | - | $98 | $251,786 | 4 | Alta Films | false | false |
| 53 | - | Then She Found Me | $1,103 | - | 7 | - | $157 | $492,399 | 6 | Paramount Pictures International | false | false |
| 54 | 46 | Lemon Tree | $1,072 | -65.4% | 3 | +1 | $357 | $546,529 | 20 | Golem Distribución | false | false |
| 55 | 50 | Lissi und der wilde Kaiser | $854 | -62.4% | 4 | -3 | $213 | $922,106 | 10 | Warner Bros. | false | false |
| 56 | 48 | Cartas para Jenny | $786 | -69.6% | 2 | -9 | $393 | $34,825 | 3 | N/A | false | false |
| 57 | 52 | Bella | $777 | -43.2% | 2 | - | $388 | $2,507,983 | 15 | E.D. Distribution | false | false |
| 58 | 56 | La banda en la isla de la magia | $424 | -43.7% | 4 | - | $106 | $29,713 | 9 | - | false | false |
| 59 | 59 | Quarantine | $342 | -3.9% | 1 | -7 | $342 | $1,266,332 | 6 | Filmax | false | false |
| 60 | 43 | Arropiero, el vagabundo de la muerte | $218 | -94.1% | 2 | -1 | $109 | $56,355 | 4 | Baditri | false | false |
| 61 | 53 | Estomago: A Gastronomic Story | $152 | -88.8% | 2 | -4 | $76 | $262,553 | 9 | Alta Films | false | false |
| 62 | 55 | Heartbeat Detector | $132 | -86% | 1 | - | $132 | $108,950 | 14 | - | false | false |
| 63 | 61 | Quantum of Solace | $121 | -7.6% | 1 | -1 | $121 | $11,959,155 | 13 | Sony Pictures Releasing | false | false |
| 64 | 51 | The Blind Sunflowers | $82 | -95.1% | 1 | -5 | $82 | $5,744,235 | 25 | Alta Films | false | false |
| 65 | - | Roman Polanski: Wanted and Desired | $39 | - | 1 | - | $39 | $39 | 1 | N/A | true | false |
| 66 | - | Burn After Reading | $27 | - | 1 | - | $27 | $9,898,714 | 19 | Universal Pictures International (UPI) | false | false |
