| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Curious Case of Benjamin Button | $679,643 | - | 88 | - | $7,723 | $704,504 | 1 | Warner Bros. | true | false |
| 2 | 1 | Valkyrie | $660,106 | -27.2% | 96 | - | $6,876 | $1,787,021 | 2 | Warner Bros. | false | false |
| 3 | 2 | Yes Man | $359,443 | -25.5% | 88 | +1 | $4,084 | $2,737,172 | 4 | Warner Bros. | false | false |
| 4 | 3 | Winter in Wartime | $201,665 | -26.8% | 100 | - | $2,016 | $6,932,997 | 10 | Benelux Film Distributors | false | false |
| 5 | 4 | Australia | $198,407 | -26.9% | 96 | -4 | $2,066 | $3,673,649 | 7 | Warner Bros. | false | false |
| 6 | 5 | Revolutionary Road | $131,933 | -30.3% | 44 | - | $2,998 | $383,849 | 2 | Universal Pictures International (UPI) | false | false |
| 7 | 7 | Madagascar: Escape 2 Africa | $126,542 | -14.4% | 111 | -12 | $1,140 | $7,886,332 | 11 | Universal Pictures International (UPI) | false | false |
| 8 | - | Gomorrah | $117,299 | - | 23 | - | $5,099 | $126,656 | 1 | Cinemien | true | false |
| 9 | 6 | Seven Pounds | $96,752 | -38.1% | 41 | - | $2,359 | $620,050 | 3 | Sony Pictures Releasing | false | false |
| 10 | 8 | The Silent Army | $87,500 | -25% | 80 | -4 | $1,093 | $2,672,720 | 8 | Independent Films | false | false |
| 11 | 10 | High School Musical 3: Senior Year | $69,947 | -11.1% | 98 | -3 | $713 | $2,650,138 | 8 | Walt Disney Pictures | false | false |
| 12 | 9 | Zack and Miri Make a Porno | $56,557 | -41.2% | 55 | - | $1,028 | $210,498 | 2 | Benelux Film Distributors | false | false |
| 13 | 12 | Milk | $52,334 | -18% | 21 | - | $2,492 | $147,878 | 2 | A-Film Distribution | false | false |
| 14 | 11 | Righteous Kill | $44,571 | -31.4% | 19 | -4 | $2,345 | $424,887 | 4 | Moonlight Films | false | false |
| 15 | 13 | Vicky Cristina Barcelona | $40,261 | -33.4% | 22 | +2 | $1,830 | $967,663 | 8 | Cinéart | false | false |
| 16 | 14 | Bedtime Stories | $37,770 | -30.3% | 57 | -3 | $662 | $1,337,412 | 6 | Walt Disney Pictures | false | false |
| 17 | 15 | The Boy in the Striped Pajamas | $29,574 | -12.4% | 27 | -1 | $1,095 | $232,569 | 4 | Walt Disney Pictures | false | false |
| 18 | - | The Goal of My Life | $24,657 | - | - | - | - | $34,054 | 1 | N/A | true | false |
| 19 | 19 | Piet Piraat en het zwaard van Zilvertand | $20,158 | -10.5% | 66 | -4 | $305 | $484,913 | 7 | Independent Films | false | false |
| 20 | - | The Flight Before Christmas | $19,019 | - | 53 | - | $358 | $708,440 | 7 | RCV Film Distribution | false | false |
| 21 | 20 | Bride Flight | $16,715 | -23% | 28 | -2 | $596 | $3,466,891 | 16 | A-Film Distribution | false | false |
| 22 | 22 | Quantum of Solace | $8,205 | -33.4% | 9 | -10 | $911 | $8,887,279 | 13 | Sony Pictures Releasing | false | false |
| 23 | - | Can Go Through Skin | $6,675 | - | 7 | - | $953 | $7,359 | 1 | Benelux Film Distributors | true | false |
| 24 | - | The Ramen Girl | $6,675 | - | 7 | - | $953 | $7,782 | 1 | N/A | true | false |
| 25 | - | Burn After Reading | $5,629 | - | 5 | - | $1,125 | $1,820,048 | 14 | Universal Pictures International (UPI) | false | false |
| 26 | - | Vinyan | $1,057 | - | 5 | - | $211 | $2,894 | 1 | Moonlight Films | true | false |
