| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Curious Case of Benjamin Button | $684,481 | - | 70 | - | $9,778 | $698,638 | 1 | Warner Bros. | true | false |
| 2 | 1 | Valkyrie | $367,134 | -41.6% | 75 | +5 | $4,895 | $1,049,203 | 2 | 20th Century Fox International | false | false |
| 3 | - | LOL (Laughing Out Loud) | $165,624 | - | 14 | - | $11,830 | $165,625 | 1 | Alternative Films | true | false |
| 4 | 2 | Revolutionary Road | $143,002 | -41.3% | 43 | - | $3,325 | $777,071 | 3 | Universal Pictures International (UPI) | false | false |
| 5 | 3 | Yes Man | $141,918 | -35.2% | 35 | -20 | $4,054 | $1,971,459 | 6 | Warner Bros. | false | false |
| 6 | - | Role Models | $135,605 | - | 24 | - | $5,650 | $135,605 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 4 | Slumdog Millionaire | $135,550 | -26.2% | 23 | +1 | $5,893 | $737,569 | 4 | Cinéart | false | false |
| 8 | 5 | Twilight | $123,260 | -25.7% | 54 | - | $2,282 | $2,933,474 | 11 | Belga Films | false | false |
| 9 | 6 | De l'autre côté du lit | $108,050 | -33.7% | 28 | - | $3,858 | $1,035,608 | 5 | Belga Films | false | false |
| 10 | 8 | Madagascar: Escape 2 Africa | $97,663 | -23.3% | 80 | -8 | $1,220 | $6,203,858 | 10 | Universal Pictures International (UPI) | false | false |
| 11 | 7 | Seven Pounds | $85,197 | -45.6% | 30 | - | $2,839 | $838,367 | 4 | Sony Pictures Releasing | false | false |
| 12 | 11 | Loft | $48,578 | -20.4% | 30 | -5 | $1,619 | $9,361,300 | 16 | Independent Films | false | false |
| 13 | 9 | The Women | $41,922 | -43.8% | 17 | - | $2,466 | $162,889 | 2 | Belga Films | false | false |
| 14 | 10 | Dirty Mind | $41,551 | -40.4% | 18 | - | $2,308 | $119,645 | 2 | Kinepolis Film Distribution (KFD) | false | false |
| 15 | 12 | Australia | $29,612 | -51.1% | 40 | -10 | $740 | $1,707,843 | 8 | 20th Century Fox International | false | false |
| 16 | 14 | The Flight Before Christmas | $29,589 | -26.6% | 31 | - | $954 | $643,291 | 8 | Kinepolis Film Distribution (KFD) | false | false |
| 17 | 13 | Burn After Reading | $26,441 | -42.2% | 17 | -5 | $1,555 | $1,481,773 | 9 | Universal Pictures International (UPI) | false | false |
| 18 | 18 | Trouble at Timpetill | $22,851 | -25% | 15 | +1 | $1,523 | $520,570 | 8 | Alternative Films | false | false |
| 19 | 16 | The Duchess | $22,041 | -43.6% | 23 | -1 | $958 | $429,083 | 5 | Cinéart | false | false |
| 20 | 17 | Bedtime Stories | $20,727 | -40.1% | 25 | -10 | $829 | $957,444 | 7 | Walt Disney Pictures | false | false |
| 21 | 19 | Piet Piraat en het zwaard van Zilvertand | $19,147 | -28.6% | 24 | -4 | $797 | $588,534 | 9 | Kinepolis Film Distribution (KFD) | false | false |
| 22 | 15 | Beauties at War | $17,694 | -55.9% | 16 | -1 | $1,105 | $250,529 | 4 | Belga Films | false | false |
| 23 | 23 | Two Lovers | $15,019 | -20% | 10 | - | $1,501 | $448,971 | 7 | Cinéart | false | false |
| 24 | 22 | Transporter 3 | $10,859 | -52.9% | 8 | -16 | $1,357 | $1,282,285 | 9 | Belga Films | false | false |
| 25 | 21 | Eden Lake | $10,670 | -56.5% | 6 | -1 | $1,778 | $80,109 | 3 | Benelux Film Distributors | false | false |
| 26 | - | King Guillaume | $10,238 | - | 8 | - | $1,279 | $10,238 | 1 | Les Films de l'Elysée | true | false |
| 27 | 25 | Frost/Nixon | $9,285 | -40.7% | 11 | -1 | $844 | $127,343 | 4 | Universal Pictures International (UPI) | false | false |
| 28 | 24 | Private Lessons | $9,012 | -45.4% | 9 | +1 | $1,001 | $62,600 | 3 | Cinéart | false | false |
| 29 | 20 | Special Correspondents | $8,648 | -65.9% | 10 | -5 | $864 | $87,862 | 3 | Victory Productions | false | false |
| 30 | 30 | Il Divo | $7,479 | -26.6% | 6 | -2 | $1,246 | $75,922 | 4 | ABC Distribution | false | false |
| 31 | 34 | Winter in Wartime | $7,449 | -13% | 10 | -4 | $744 | $337,749 | 10 | Benelux Film Distributors | false | false |
| 32 | 38 | High School Musical 3: Senior Year | $6,857 | +4.7% | 4 | - | $1,714 | $2,845,100 | 15 | Walt Disney Pictures | false | false |
| 33 | 36 | Pride and Glory | $6,743 | -13.9% | 2 | - | $3,371 | $216,959 | 10 | Kinepolis Film Distribution (KFD) | false | false |
| 34 | 37 | Changeling | $5,703 | -13.6% | 5 | -3 | $1,140 | $964,609 | 13 | Universal Pictures International (UPI) | false | false |
| 35 | 45 | The Baader Meinhof Complex | $5,602 | +45.7% | 6 | - | $933 | $15,315 | 2 | A-Film Distribution | false | false |
| 36 | 26 | Afterwards | $5,381 | -60% | 11 | - | $489 | $88,415 | 4 | Victory Productions | false | false |
| 37 | 33 | Blinker en de blixvaten | $5,259 | -39.2% | 11 | -3 | $478 | $270,375 | 8 | Kinepolis Film Distribution (KFD) | false | false |
| 38 | 27 | The Heir Apparent: Largo Winch | $4,576 | -64.4% | 7 | -9 | $653 | $614,300 | 8 | Cinéart | false | false |
| 39 | 35 | Quantum of Solace | $3,987 | -50.1% | 1 | - | $3,987 | $4,745,885 | 14 | Sony Pictures Releasing | false | false |
| 40 | 42 | Stella | $2,692 | -40.2% | 4 | -2 | $673 | $22,241 | 4 | Benelux Film Distributors | false | false |
| 41 | - | The Joy of Singing | $2,682 | - | 2 | - | $1,341 | $2,682 | 1 | Les Films de l'Elysée | true | false |
| 42 | 32 | The Class | $2,624 | -70% | 7 | -4 | $374 | $895,100 | 19 | Cinéart | false | false |
| 43 | 39 | Welcome to the Sticks | $2,323 | -61.7% | 3 | -3 | $774 | $10,707,893 | 50 | Alternative Films | false | false |
| 44 | 31 | Elite Squad | $1,523 | -83.9% | 2 | -7 | $761 | $48,792 | 3 | Benelux Film Distributors | false | false |
| 45 | 49 | Modern Life | $1,394 | -12.3% | 2 | - | $697 | $52,285 | 14 | Benelux Film Distributors | false | false |
| 46 | 52 | Elegy | $1,355 | +105.6% | 4 | +1 | $338 | $177,622 | 16 | Kinepolis Film Distribution (KFD) | false | false |
| 47 | 43 | Appaloosa | $1,165 | -72% | 4 | - | $291 | $87,261 | 5 | Paradiso Entertainment | false | false |
| 48 | 46 | Wild Child | $1,151 | -69.6% | 3 | -3 | $383 | $196,472 | 7 | Universal Pictures International (UPI) | false | false |
| 49 | 50 | Moscow, Belgium | $1,107 | -6.6% | 1 | -3 | $1,107 | $1,888,300 | 54 | Kinepolis Film Distribution (KFD) | false | false |
| 50 | - | La influencia | $863 | - | 1 | - | $863 | $863 | 1 | N/A | true | false |
| 51 | 48 | Anubis en het Pad der 7 Zonden | $718 | -73% | 2 | -1 | $359 | $1,510,876 | 17 | Kinepolis Film Distribution (KFD) | false | false |
| 52 | 54 | The Wave | $676 | +34.9% | 3 | +1 | $225 | $55,560 | 16 | Paradiso Entertainment | false | false |
| 53 | 28 | The Day the Earth Stood Still | $582 | -95.4% | 3 | -7 | $194 | $1,939,964 | 9 | 20th Century Fox International | false | false |
| 54 | - | I Want to See | $509 | - | 2 | - | $254 | $509 | 1 | Les Films de l'Elysée | true | false |
| 55 | - | Bottle Shock | $384 | - | 6 | - | $64 | $384 | 1 | N/A | true | false |
| 56 | 29 | Diamond 13 | $379 | -97% | 2 | -7 | $189 | $15,925 | 2 | Les Films de l'Elysée | false | false |
| 57 | 53 | Hunger | $339 | -44.5% | 3 | -1 | $113 | $38,753 | 13 | Paradiso Entertainment | false | false |
| 58 | - | Religulous | $212 | - | 2 | - | $106 | $5,365 | 3 | A-Film Distribution | false | false |
| 59 | 47 | Christmas in Paris | $190 | -93.1% | 2 | -1 | $95 | $229,487 | 8 | Kinepolis Film Distribution (KFD) | false | false |
