| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Bolt | $634,157 | - | 92 | - | $6,893 | $635,905 | 1 | Walt Disney Pictures | true | false |
| 2 | - | Yes Man | $261,353 | - | 50 | - | $5,227 | $261,353 | 1 | Warner Bros. | true | false |
| 3 | 1 | The Day the Earth Stood Still | $209,963 | -41.8% | 122 | - | $1,721 | $1,689,668 | 3 | 20th Century Fox International | false | false |
| 4 | 2 | Twilight | $198,106 | -30.2% | 87 | +10 | $2,277 | $1,351,023 | 3 | Alfa Films | false | false |
| 5 | 3 | Australia | $139,279 | -37.7% | 60 | - | $2,321 | $458,989 | 2 | 20th Century Fox International | false | false |
| 6 | - | Doubt | $128,808 | - | 26 | - | $4,954 | $128,808 | 1 | Walt Disney Pictures | true | false |
| 7 | 4 | Madagascar: Escape 2 Africa | $116,499 | -44% | 106 | -37 | $1,099 | $5,273,076 | 7 | Paramount Pictures International | false | false |
| 8 | 6 | Rudo y Cursi | $61,483 | -47% | 45 | - | $1,366 | $235,927 | 2 | United International Pictures | false | false |
| 9 | - | Bangkok Dangerous | $50,089 | - | 31 | - | $1,615 | $50,089 | 1 | Distribution Company | true | false |
| 10 | 5 | El ratón Pérez 2 | $48,387 | -62.9% | 98 | +9 | $493 | $621,365 | 3 | Walt Disney Pictures | false | false |
| 11 | - | W. | $32,680 | - | 13 | - | $2,513 | $32,680 | 1 | Impacto Cine | true | false |
| 12 | 8 | Four Christmases | $14,613 | -48.5% | 24 | -10 | $608 | $398,625 | 5 | Distribution Company | false | false |
| 13 | 9 | Body of Lies | $12,917 | -45.2% | 32 | -8 | $403 | $911,277 | 8 | Warner Bros. | false | false |
| 14 | 10 | The Duchess | $9,095 | -30.6% | 10 | -4 | $909 | $231,754 | 6 | United International Pictures | false | false |
| 15 | 26 | Planet Terror | $4,426 | +257.2% | 11 | +3 | $402 | $87,663 | 6 | Pachamama Cine | false | false |
| 16 | 13 | Che: Part One | $4,106 | -45.9% | 6 | -3 | $684 | $663,354 | 10 | Alfa Films | false | false |
| 17 | - | Bug | $3,988 | - | 3 | - | $1,329 | $3,988 | 1 | Alfa Films | true | false |
| 18 | 20 | Late Bloomers | $3,707 | +13.8% | 4 | +1 | $926 | $68,242 | 8 | Primer Plano Film Group | false | false |
| 19 | 14 | High School Musical 3: Senior Year | $3,694 | -50% | 8 | -9 | $461 | $1,195,577 | 8 | Walt Disney Pictures | false | false |
| 20 | 11 | Quarantine | $3,528 | -57.4% | 8 | -16 | $441 | $329,268 | 7 | Sony Pictures Releasing | false | false |
| 21 | 17 | The Pope's Toilet | $3,285 | -36.7% | 4 | -2 | $821 | $24,626 | 3 | Primer Plano Film Group | false | false |
| 22 | 12 | Righteous Kill | $2,697 | -66% | 7 | -10 | $385 | $563,690 | 9 | CDI Films | false | false |
| 23 | 35 | RocknRolla | $2,460 | +300.7% | 3 | - | $820 | $78,556 | 6 | Warner Bros. | false | false |
| 24 | 7 | Asterix at the Olympic Games | $2,170 | -92.5% | 11 | -23 | $197 | $45,371 | 2 | Distribution Company | false | false |
| 25 | 16 | The Tracker 2008 Re-release | $1,546 | -77% | 3 | -2 | $515 | $45,699 | 4 | IFA | false | false |
| 26 | 19 | Quantum of Solace | $1,333 | -68.1% | 2 | -4 | $666 | $1,160,033 | 11 | Sony Pictures Releasing | false | false |
| 27 | 21 | Death Sentence | $1,271 | -49.7% | 3 | -3 | $423 | $186,600 | 7 | Distribution Company | false | false |
| 28 | 43 | Saw V | $970 | +410.5% | 2 | - | $485 | $1,048,993 | 12 | Walt Disney Pictures | false | false |
| 29 | 51 | Ira & Abby | $970 | +2,752.9% | 1 | - | $970 | $44,301 | 6 | CDI Films | false | false |
| 30 | 33 | Beverly Hills Chihuahua | $958 | +23.6% | 3 | -1 | $319 | $1,558,888 | 15 | Walt Disney Pictures | false | false |
| 31 | 27 | Elegy | $753 | -35.5% | 1 | -3 | $753 | $173,859 | 9 | Distribution Company | false | false |
| 32 | 30 | Flawless | $674 | -29.4% | 2 | - | $337 | $254,653 | 11 | Distribution Company | false | false |
| 33 | 32 | Aniceto | $664 | -24.9% | 2 | -1 | $332 | $132,602 | 32 | Primer Plano Film Group | false | false |
| 34 | 37 | The Boy in the Striped Pajamas | $533 | +2.7% | 2 | -1 | $266 | $77,317 | 7 | Walt Disney Pictures | false | false |
| 35 | 23 | Tear This Heart Out | $480 | -76.6% | 3 | -4 | $160 | $53,903 | 8 | 20th Century Fox International | false | false |
| 36 | 36 | Fados | $472 | -18.5% | 1 | - | $472 | $34,423 | 8 | Distribution Company | false | false |
| 37 | 34 | Manual of Love 2008 Re-release | $442 | -31.6% | 2 | - | $221 | $135,120 | 17 | Notro Films | false | false |
| 38 | 41 | Four Minutes | $283 | +9.7% | 1 | - | $283 | $158,951 | 21 | Alfa Films | false | false |
| 39 | 39 | Burn After Reading | $271 | -15.3% | 1 | - | $271 | $852,081 | 13 | United International Pictures | false | false |
| 40 | 28 | Ben X | $268 | -73.8% | 4 | -1 | $67 | $26,465 | 3 | Distribution Company | false | false |
| 41 | 47 | The Magic Flute | $222 | +85% | 2 | +1 | $111 | $26,845 | 13 | Distribution Company | false | false |
| 42 | - | Nights in Rodanthe | $182 | - | 1 | - | $182 | $879,399 | 16 | Warner Bros. | false | false |
| 43 | 22 | Bella | $162 | -93.4% | 1 | -5 | $162 | $49,112 | 4 | CDI Films | false | false |
| 44 | 46 | Days of Darkness | $144 | +0.7% | 1 | - | $144 | $15,594 | 14 | Alfa Films | false | false |
| 45 | 42 | My Brother is an Only Child | $133 | -44.6% | 1 | - | $133 | $221,718 | 18 | Alfa Films | false | false |
| 46 | 44 | Shara | $121 | -15.4% | 1 | - | $121 | $43,759 | 12 | Zeta Films | false | false |
| 47 | 25 | The Bank Job | $113 | -91.7% | 1 | -3 | $113 | $625,583 | 14 | Alfa Films | false | false |
| 48 | 49 | Café de los maestros | $109 | +118% | 1 | - | $109 | $96,202 | 30 | Alfa Films | false | false |
| 49 | 45 | Mamma Mia! | $104 | -27.3% | 1 | - | $104 | $1,446,496 | 22 | United International Pictures | false | false |
| 50 | 31 | Max Payne | $61 | -93.2% | 1 | -4 | $61 | $166,631 | 9 | 20th Century Fox International | false | false |
| 51 | 50 | Two Friends and a Burglar | $58 | +45% | 1 | - | $58 | $9,425 | 8 | Primer Plano Film Group | false | false |
| 52 | 18 | Fly Me to the Moon 3D | $39 | -99.2% | 1 | -7 | $39 | $130,412 | 5 | Distribution Company | false | false |
