| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Gran Torino | $29,025,000 | $29,484,388 | +$459,388 | +1.6% | 2,808 | $40,065,000 | $40,524,518 | 5 | Warner Bros. | - |
| 2 | 2 | - | Bride Wars | $21,500,000 | $21,058,173 | -$441,827 | -2.1% | 3,226 | $21,500,000 | $21,058,173 | 1 | Twentieth Century Fox | - |
| 3 | 3 | - | The Unborn | $21,095,000 | $19,810,585 | -$1,284,415 | -6.1% | 2,357 | $21,095,000 | $19,810,585 | 1 | Universal Pictures | - |
| 4 | 4 | - | Marley & Me | $11,350,000 | $11,391,425 | +$41,425 | +0.4% | 3,478 | $123,710,000 | $123,751,596 | 3 | Twentieth Century Fox | - |
| 5 | 5 | - | The Curious Case of Benjamin Button | $9,450,000 | $9,212,515 | -$237,485 | -2.5% | 2,947 | $94,330,000 | $94,092,395 | 3 | Paramount Pictures | - |
| 6 | 6 | - | Bedtime Stories | $8,550,000 | $8,802,120 | +$252,120 | +2.9% | 3,511 | $97,180,000 | $97,432,093 | 3 | Walt Disney Studios Motion Pictures | - |
| 7 | 7 | - | Valkyrie | $6,662,000 | $6,617,065 | -$44,935 | -0.7% | 2,838 | $71,509,000 | $71,464,448 | 3 | United Artists | - |
| 8 | 8 | - | Yes Man | $6,155,000 | $6,032,337 | -$122,663 | -2% | 2,955 | $89,410,000 | $89,288,024 | 4 | Warner Bros. | - |
| 9 | 9 | - | Not Easily Broken | $5,600,000 | $5,314,278 | -$285,722 | -5.1% | 724 | $5,600,000 | $5,314,278 | 1 | Screen Gems | - |
| 10 | 10 | - | Seven Pounds | $3,900,000 | $3,818,230 | -$81,770 | -2.1% | 2,456 | $66,830,000 | $66,748,686 | 4 | Sony Pictures Releasing | - |
| 11 | 11 | - | Slumdog Millionaire | $3,730,000 | $3,782,340 | +$52,340 | +1.4% | 601 | $34,075,000 | $34,127,195 | 9 | Fox Searchlight Pictures | - |
| 12 | 12 | - | Twilight | $2,789,000 | $2,841,852 | +$52,852 | +1.9% | 1,466 | $181,396,000 | $181,448,642 | 8 | Summit Entertainment | - |
| 13 | 13 | - | The Tale of Despereaux | $2,642,000 | $2,733,585 | +$91,585 | +3.5% | 2,297 | $47,492,000 | $47,584,450 | 4 | Universal Pictures | - |
| 14 | 14 | - | Doubt | $2,503,000 | $2,521,118 | +$18,118 | +0.7% | 1,287 | $22,941,000 | $22,959,422 | 5 | Miramax | - |
| 15 | 15 | - | The Day the Earth Stood Still | $1,550,000 | $1,550,629 | +$629 | <0.1% | 1,512 | $77,330,000 | $77,330,238 | 5 | Twentieth Century Fox | - |
| 16 | 16 | - | Revolutionary Road | $1,440,000 | $1,427,744 | -$12,256 | -0.9% | 135 | $3,170,000 | $3,158,054 | 3 | Paramount Vantage | - |
| 17 | 18 | +1 | The Reader | $1,352,000 | $1,346,742 | -$5,258 | -0.4% | 507 | $5,516,000 | $5,510,453 | 5 | The Weinstein Company | - |
| 18 | 17 | -1 | Bolt | $1,346,000 | $1,370,487 | +$24,487 | +1.8% | 1,161 | $111,783,000 | $111,806,897 | 8 | Walt Disney Studios Motion Pictures | - |
| 19 | 19 | - | Milk | $1,251,000 | $1,296,051 | +$45,051 | +3.6% | 295 | $19,125,000 | $19,163,996 | 7 | Focus Features | - |
| 20 | 20 | - | Frost/Nixon | $912,000 | $891,627 | -$20,373 | -2.2% | 205 | $7,652,000 | $7,631,181 | 6 | Universal Pictures | - |
| 21 | 21 | - | The Wrestler | $874,000 | $848,410 | -$25,590 | -2.9% | 60 | $2,848,000 | $2,822,431 | 4 | Fox Searchlight Pictures | - |
| 22 | 22 | - | Australia | $600,000 | $617,314 | +$17,314 | +2.9% | 543 | $47,747,000 | $47,764,206 | 7 | Twentieth Century Fox | - |
| 23 | 23 | - | The Spirit | $560,000 | $558,480 | -$1,520 | -0.3% | 1,088 | $19,448,000 | $19,446,189 | 3 | Lionsgate | - |
| 24 | 25 | +1 | Four Christmases | $415,000 | $373,436 | -$41,564 | -10% | 777 | $119,250,000 | $119,209,383 | 7 | Warner Bros. | - |
| 25 | 26 | +1 | Madagascar: Escape 2 Africa | $305,000 | $319,301 | +$14,301 | +4.7% | 375 | $177,481,000 | $177,495,492 | 10 | DreamWorks | - |
| 26 | 28 | +2 | Rachel Getting Married | $205,000 | $179,805 | -$25,195 | -12.3% | 96 | $10,379,000 | $10,558,970 | 15 | Sony Pictures Classics | - |
| 27 | 29 | +2 | Role Models | $157,000 | $168,175 | +$11,175 | +7.1% | 251 | $66,960,000 | $66,971,710 | 10 | Universal Pictures | - |
| 28 | 30 | +2 | Last Chance Harvey | $151,000 | $141,671 | -$9,329 | -6.2% | 16 | $541,000 | $531,825 | 3 | Overture Films | - |
| 29 | 34 | +5 | Waltz with Bashir | $80,900 | $70,737 | -$10,163 | -12.6% | 8 | $364,000 | $374,325 | 3 | Sony Pictures Classics | - |
| 30 | 35 | +5 | Defiance | $66,000 | $68,183 | +$2,183 | +3.3% | 2 | $307,000 | $309,017 | 2 | Paramount Vantage | - |
| 31 | 39 | +8 | I've Loved You So Long | $48,300 | $52,340 | +$4,040 | +8.4% | 33 | $2,458,000 | $2,462,429 | 12 | Sony Pictures Classics | - |
| 32 | 41 | +9 | Synecdoche, New York | $47,400 | $48,362 | +$962 | +2% | 41 | $2,780,000 | $2,780,920 | 12 | Sony Pictures Classics | - |
| 33 | 42 | +9 | Zack and Miri Make a Porno | $46,000 | $47,878 | +$1,878 | +4.1% | 103 | $31,381,000 | $31,382,624 | 11 | The Weinstein Company | - |
| 34 | 47 | +13 | Che: Part One/Che: Part Two | $37,500 | $37,613 | +$113 | +0.3% | 5 | $294,000 | $293,708 | 5 | IFC Films | - |
| 35 | 46 | +11 | Vicky Cristina Barcelona | $36,000 | $38,628 | +$2,628 | +7.3% | 38 | $22,883,000 | $22,886,033 | 22 | Metro-Goldwyn-Mayer (MGM) | - |
| 36 | 50 | +14 | Nothing Like the Holidays | $22,000 | $22,227 | +$227 | +1% | 62 | $7,478,000 | $7,478,384 | 5 | Overture Films | - |
| 37 | 58 | +21 | Wendy and Lucy | $17,500 | $16,822 | -$678 | -3.9% | 5 | $141,000 | $140,520 | 5 | Oscilloscope | - |
