| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Four Christmases | $144,686 | - | 50 | - | $2,893 | $144,686 | 1 | NuMetro Distribution | true | false |
| 2 | 1 | Yes Man | $112,629 | -55% | 60 | - | $1,877 | $491,578 | 2 | NuMetro Distribution | false | false |
| 3 | 2 | Mr. Bones 2: Back from the Past | $96,918 | -37.5% | 82 | -11 | $1,181 | $3,210,825 | 7 | United International Pictures | false | false |
| 4 | 3 | Bolt | $77,473 | -29.2% | 68 | -6 | $1,139 | $734,514 | 3 | Ster-Kinekor Pictures | false | false |
| 5 | 4 | Madagascar: Escape 2 Africa | $68,864 | -36.5% | 79 | -15 | $871 | $1,956,389 | 6 | United International Pictures | false | false |
| 6 | - | Burn After Reading | $63,997 | - | 22 | - | $2,908 | $63,997 | 1 | Ster-Kinekor Pictures | true | false |
| 7 | 8 | Twilight | $59,863 | -17.2% | 46 | - | $1,301 | $564,229 | 4 | NuMetro Distribution | false | false |
| 8 | 7 | Australia | $50,586 | -32% | 57 | -6 | $887 | $403,686 | 3 | NuMetro Distribution | false | false |
| 9 | 5 | The Tale of Despereaux | $46,799 | -52% | 49 | - | $955 | $205,758 | 2 | United International Pictures | false | false |
| 10 | - | City of Ember | $32,088 | - | 30 | - | $1,069 | $32,088 | 1 | NuMetro Distribution | true | false |
| 11 | 6 | Pride and Glory | $30,725 | -64.2% | 40 | - | $768 | $155,680 | 2 | NuMetro Distribution | false | false |
| 12 | 9 | Quantum of Solace | $24,307 | -43% | 31 | -17 | $784 | $1,984,009 | 8 | Ster-Kinekor Pictures | false | false |
| 13 | 12 | The Day the Earth Stood Still | $18,788 | -43.6% | 39 | -3 | $481 | $643,025 | 5 | NuMetro Distribution | false | false |
| 14 | 10 | Vicky Cristina Barcelona | $18,418 | -50.1% | 17 | - | $1,083 | $74,443 | 2 | United International Pictures | false | false |
| 15 | 11 | Vaatjie Sien sy Gat | $17,882 | -46.6% | 23 | -9 | $777 | $179,740 | 3 | Ster-Kinekor Pictures | false | false |
| 16 | 13 | Make It Happen | $12,019 | -46.6% | 32 | -7 | $375 | $265,842 | 4 | United International Pictures | false | false |
| 17 | 14 | The Women | $8,074 | -35.9% | 16 | - | $504 | $364,570 | 6 | Ster-Kinekor Pictures | false | false |
| 18 | 15 | Rab Ne Bana Di Jodi | $7,875 | -27.7% | 8 | +1 | $984 | $151,184 | 5 | NuMetro Distribution | false | false |
| 19 | 16 | Wild Child | $4,432 | -46.7% | 13 | -5 | $340 | $467,478 | 9 | United International Pictures | false | false |
| 20 | 20 | Boy A | $2,579 | -9.3% | 3 | - | $859 | $14,561 | 3 | Ster-Kinekor Pictures | false | false |
| 21 | 21 | The Boy in the Striped Pajamas | $2,481 | -8.9% | 4 | - | $620 | $39,707 | 6 | Ster-Kinekor Pictures | false | false |
| 22 | 24 | Nick and Norah's Infinite Playlist | $2,208 | +7.4% | 5 | -1 | $441 | $45,298 | 4 | Ster-Kinekor Pictures | false | false |
| 23 | 19 | How to Lose Friends & Alienate People | $531 | -84% | 1 | -2 | $531 | $39,651 | 4 | United International Pictures | false | false |
| 24 | 25 | Fugitive Pieces | $451 | -58.6% | 1 | -1 | $451 | $23,048 | 11 | United International Pictures | false | false |
