| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Seven Pounds | $5,248,059 | - | 553 | - | $9,490 | $5,248,059 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | Yes Man | $3,402,505 | - | 349 | - | $9,749 | $3,402,505 | 1 | Warner Bros. | true | false |
| 3 | 1 | Madagascar: Escape 2 Africa | $1,372,435 | -65.1% | 421 | -150 | $3,259 | $32,405,808 | 4 | Universal Pictures International (UPI) | false | false |
| 4 | 2 | Natale a Rio | $917,377 | -76% | 337 | -211 | $2,722 | $35,720,934 | 4 | Filmauro | false | false |
| 5 | - | Easy Virtue | $820,973 | - | 126 | - | $6,515 | $820,973 | 1 | Eagle Pictures | true | false |
| 6 | 4 | Nights in Rodanthe | $494,720 | -63.2% | 253 | -63 | $1,955 | $8,136,293 | 4 | Warner Bros. | false | false |
| 7 | 5 | The Strangers | $460,302 | -65% | 162 | -3 | $2,841 | $2,510,754 | 2 | Universal Pictures International (UPI) | false | false |
| 8 | 3 | Il cosmo sul comò | $440,470 | -76.8% | 238 | -221 | $1,850 | $19,168,357 | 4 | Medusa Distribuzione | false | false |
| 9 | - | Let the Right One In | $321,859 | - | 132 | - | $2,438 | $321,859 | 1 | Bolero Film | true | false |
| 10 | 7 | The Boy in the Striped Pajamas | $281,278 | -47.4% | 101 | -2 | $2,784 | $2,638,862 | 4 | Walt Disney Pictures | false | false |
| 11 | 10 | Slumdog Millionaire | $235,488 | -31.4% | 87 | +17 | $2,706 | $2,802,425 | 6 | Lucky Red | false | false |
| 12 | 6 | The Duchess | $190,174 | -65.7% | 142 | -60 | $1,339 | $2,602,107 | 3 | BIM Distribuzione | false | false |
| 13 | 13 | The Visitor | $180,758 | -21.6% | 57 | +9 | $3,171 | $1,463,998 | 6 | Bolero Film | false | false |
| 14 | 15 | Lemon Tree | $151,728 | -21.9% | 47 | +4 | $3,228 | $889,224 | 5 | Teodora Film | false | false |
| 15 | - | Waltz with Bashir | $131,428 | - | 21 | - | $6,258 | $131,428 | 1 | Lucky Red | true | false |
| 16 | 12 | Lissi und der wilde Kaiser | $108,509 | -60% | 107 | -49 | $1,014 | $579,494 | 2 | Moviemax | false | false |
| 17 | 9 | As God Commands | $75,818 | -79.4% | 64 | -103 | $1,184 | $4,473,606 | 5 | 01 Distribution | false | false |
| 18 | 8 | The Spirit | $64,655 | -87.8% | 67 | -136 | $965 | $2,912,672 | 3 | Sony Pictures Releasing | false | false |
| 19 | 17 | Happy-Go-Lucky | $43,323 | -57.4% | 21 | -9 | $2,063 | $1,135,661 | 6 | Mikado Film | false | false |
| 20 | 19 | Stella | $38,415 | -30.8% | 15 | -4 | $2,561 | $367,808 | 6 | Sacher Distribuzione | false | false |
| 21 | 18 | Bolt | $28,782 | -66% | 27 | -45 | $1,066 | $7,043,584 | 7 | Walt Disney Pictures | false | false |
| 22 | 20 | We Can Do That | $26,883 | -38.1% | 13 | -1 | $2,067 | $2,360,739 | 11 | Warner Bros. | false | false |
| 23 | 14 | The Life Before Her Eyes | $26,006 | -88.5% | 38 | -44 | $684 | $392,276 | 2 | Mediafilm | false | false |
| 24 | 11 | The Day the Earth Stood Still | $24,417 | -91.6% | 16 | -99 | $1,526 | $6,118,031 | 5 | 20th Century Fox International | false | false |
| 25 | 23 | Changeling | $20,652 | -18.2% | 12 | +3 | $1,721 | $7,009,925 | 9 | Universal Pictures International (UPI) | false | false |
| 26 | 21 | Comme les autres | $19,630 | -36.3% | 17 | +2 | $1,154 | $188,250 | 4 | Archibald | false | false |
| 27 | 25 | Welcome to the Sticks | $17,364 | -23.9% | 9 | -1 | $1,929 | $4,118,455 | 11 | Medusa Distribuzione | false | false |
| 28 | 16 | City of Ember | $16,963 | -88.9% | 29 | -65 | $584 | $1,608,130 | 4 | Eagle Pictures | false | false |
| 29 | 24 | Mamma Mia! | $14,270 | -41.2% | 5 | -2 | $2,854 | $12,033,602 | 15 | United International Pictures | false | false |
| 30 | 22 | Twilight | $8,551 | -66.3% | 7 | -5 | $1,221 | $15,349,809 | 8 | Eagle Pictures | false | false |
| 31 | 26 | Just a Father | $5,958 | -66.7% | 7 | -5 | $851 | $2,966,118 | 7 | Warner Bros. | false | false |
| 32 | 31 | The Class | $4,611 | +3.5% | 2 | - | $2,305 | $2,220,818 | 14 | Mikado Film | false | false |
| 33 | 29 | The Early Bird Catches the Worm | $4,488 | -27% | 1 | - | $4,488 | $1,540,001 | 46 | Medusa Distribuzione | false | false |
| 34 | 33 | W. | $4,071 | +11.4% | 3 | +2 | $1,357 | $25,086 | 4 | N/A | false | false |
| 35 | - | Journey to the Center of the Earth | $3,595 | - | 3 | - | $1,198 | $3,595 | - | 01 Distribution | - | false |
| 36 | 30 | The Duchess of Langeais | $3,526 | -24.9% | 2 | +1 | $1,763 | $201,487 | 79 | Mikado Film | false | false |
| 37 | 27 | A Christmas Tale | $2,860 | -68.8% | 3 | -4 | $953 | $229,621 | 6 | BIM Distribuzione | false | false |
| 38 | - | Márió, a varázsló | $2,639 | - | 2 | - | $1,319 | $60,393 | 7 | L'Altrofilm | false | false |
| 39 | - | The Wind Blows Round | $2,633 | - | 2 | - | $1,316 | $680,197 | 89 | Aranciafilm | false | false |
| 40 | 28 | Body of Lies | $2,101 | -68.5% | 2 | -1 | $1,050 | $6,091,895 | 8 | Warner Bros. | false | false |
| 41 | 32 | WALL·E | $1,219 | -71.7% | 1 | -4 | $1,219 | $12,197,884 | 13 | Walt Disney Pictures | false | false |
| 42 | - | Vicky Cristina Barcelona | $1,092 | - | 1 | - | $1,092 | $8,120,300 | 13 | Medusa Distribuzione | false | false |
| 43 | - | Hoodwinked! | $762 | - | 1 | - | $762 | $1,768,995 | 137 | 01 Distribution | false | false |
| 44 | 35 | Galantuomini | $738 | -73.7% | 1 | -1 | $738 | $756,215 | 8 | 01 Distribution | false | false |
| 45 | - | Giovanna's Father | $678 | - | 1 | - | $678 | $4,802,039 | 18 | Medusa Distribuzione | false | false |
| 46 | - | In Bruges | $617 | - | 1 | - | $617 | $772,903 | 35 | Mikado Film | false | false |
| 47 | - | Donkey Xote | $609 | - | 1 | - | $609 | $70,295 | 11 | N/A | false | false |
| 48 | - | Mid-August Lunch | $579 | - | 1 | - | $579 | $2,802,555 | 19 | Fandango | false | false |
| 49 | - | High School Musical 3: Senior Year | $550 | - | 1 | - | $550 | $12,738,501 | 11 | Walt Disney Pictures | false | false |
| 50 | - | The Fox and the Child | $459 | - | 2 | - | $229 | $2,395,773 | 43 | Lucky Red | false | false |
| 51 | 36 | Rachel Getting Married | $268 | -29.1% | 3 | +1 | $89 | $266,908 | 8 | Sony Pictures Releasing | false | false |
