| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Marley & Me | $24,050,000 | $24,263,763 | +$213,763 | +0.9% | 3,505 | $106,510,000 | $106,664,046 | 2 | Twentieth Century Fox | - |
| 2 | 2 | - | Bedtime Stories | $20,317,000 | $20,501,339 | +$184,339 | +0.9% | 3,684 | $85,351,000 | $85,539,168 | 2 | Walt Disney Studios Motion Pictures | - |
| 3 | 3 | - | The Curious Case of Benjamin Button | $18,400,000 | $18,691,248 | +$291,248 | +1.6% | 2,988 | $79,011,000 | $79,297,086 | 2 | Paramount Pictures | - |
| 4 | 4 | - | Valkyrie | $14,042,000 | $14,094,617 | +$52,617 | +0.4% | 2,778 | $60,692,000 | $60,743,921 | 2 | United Artists | - |
| 5 | 5 | - | Yes Man | $13,850,000 | $13,910,477 | +$60,477 | +0.4% | 3,434 | $79,413,000 | $79,507,388 | 3 | Warner Bros. | - |
| 6 | 6 | - | Seven Pounds | $10,000,000 | $10,068,518 | +$68,518 | +0.7% | 2,758 | $60,038,000 | $60,147,298 | 3 | Sony Pictures Releasing | - |
| 7 | 7 | - | The Tale of Despereaux | $7,020,000 | $6,939,295 | -$80,705 | -1.1% | 3,091 | $43,742,000 | $43,661,775 | 3 | Universal Pictures | - |
| 8 | 9 | +1 | Doubt | $5,031,000 | $5,000,893 | -$30,107 | -0.6% | 1,287 | $18,730,000 | $18,705,481 | 4 | Miramax | - |
| 9 | 8 | -1 | The Day the Earth Stood Still | $4,850,000 | $5,049,698 | +$199,698 | +4.1% | 2,337 | $74,299,000 | $74,424,256 | 4 | Twentieth Century Fox | - |
| 10 | 10 | - | Slumdog Millionaire | $4,770,000 | $4,690,769 | -$79,231 | -1.7% | 612 | $28,779,000 | $28,676,598 | 8 | Fox Searchlight Pictures | - |
| 11 | 11 | - | Twilight | $4,530,000 | $4,648,642 | +$118,642 | +2.6% | 1,888 | $176,815,000 | $176,922,850 | 7 | Summit Entertainment | - |
| 12 | 12 | - | Bolt | $3,271,000 | $3,291,944 | +$20,944 | +0.6% | 1,729 | $109,897,000 | $109,917,145 | 7 | Walt Disney Studios Motion Pictures | - |
| 13 | 13 | - | The Spirit | $3,270,000 | $3,259,898 | -$10,102 | -0.3% | 2,508 | $17,754,000 | $17,743,738 | 2 | Lionsgate | - |
| 14 | 15 | +1 | Four Christmases | $2,870,000 | $2,811,390 | -$58,610 | -2% | 2,307 | $118,254,000 | $118,189,834 | 6 | Warner Bros. | - |
| 15 | 14 | -1 | Gran Torino | $2,820,000 | $2,936,423 | +$116,423 | +4.1% | 84 | $9,700,000 | $9,820,554 | 4 | Warner Bros. | - |
| 16 | 16 | - | Milk | $1,860,000 | $1,888,510 | +$28,510 | +1.5% | 309 | $17,124,000 | $17,157,994 | 6 | Focus Features | - |
| 17 | 17 | - | The Reader | $1,620,000 | $1,598,472 | -$21,528 | -1.3% | 398 | $3,575,000 | $3,553,578 | 4 | The Weinstein Company | - |
| 18 | 18 | - | Frost/Nixon | $1,441,000 | $1,400,484 | -$40,516 | -2.8% | 205 | $6,330,000 | $6,291,176 | 5 | Universal Pictures | - |
| 19 | 19 | - | Australia | $1,150,000 | $1,163,169 | +$13,169 | +1.1% | 765 | $46,694,000 | $46,686,713 | 6 | Twentieth Century Fox | - |
| 20 | 20 | - | Quantum of Solace | $1,100,000 | $1,130,055 | +$30,055 | +2.7% | 891 | $166,800,000 | $166,820,413 | 8 | Sony Pictures Releasing | - |
| 21 | 21 | - | Revolutionary Road | $979,000 | $985,961 | +$6,961 | +0.7% | 38 | $1,369,000 | $1,375,749 | 2 | Paramount Vantage | - |
| 22 | 22 | - | Madagascar: Escape 2 Africa | $920,000 | $958,397 | +$38,397 | +4.2% | 707 | $176,934,000 | $177,016,810 | 9 | DreamWorks | - |
| 23 | 23 | - | The Wrestler | $432,000 | $437,815 | +$5,815 | +1.3% | 18 | $1,756,000 | $1,762,043 | 3 | Fox Searchlight Pictures | - |
| 24 | 26 | +2 | Role Models | $236,000 | $247,050 | +$11,050 | +4.7% | 270 | $66,688,000 | $66,703,740 | 9 | Universal Pictures | - |
| 25 | 28 | +3 | Cadillac Records | $210,000 | $205,855 | -$4,145 | -2% | 180 | $8,138,000 | $8,134,217 | 5 | Sony Pictures Releasing | - |
| 26 | 29 | +3 | Rachel Getting Married | $186,000 | $166,733 | -$19,267 | -10.4% | 67 | $10,326,000 | $10,307,424 | 14 | Sony Pictures Classics | - |
| 27 | 30 | +3 | Nothing Like the Holidays | $158,000 | $155,967 | -$2,033 | -1.3% | 308 | $7,405,000 | $7,405,784 | 4 | Overture Films | - |
| 28 | 32 | +4 | Defiance | $121,000 | $123,513 | +$2,513 | +2.1% | 2 | $198,000 | $200,614 | 1 | Paramount Vantage | - |
| 29 | 33 | +4 | Last Chance Harvey | $107,000 | $102,206 | -$4,794 | -4.5% | 6 | $356,000 | $350,947 | 2 | Overture Films | - |
| 30 | 36 | +6 | I've Loved You So Long | $105,000 | $89,378 | -$15,622 | -14.9% | 42 | $2,372,000 | $2,355,979 | 11 | Sony Pictures Classics | - |
| 31 | 38 | +7 | Changeling | $82,000 | $80,040 | -$1,960 | -2.4% | 125 | $35,694,000 | $35,707,327 | 11 | Universal Pictures | - |
| 32 | 41 | +9 | Zack and Miri Make a Porno | $67,000 | $67,517 | +$517 | +0.8% | 102 | $31,301,000 | $31,300,810 | 10 | The Weinstein Company | - |
| 33 | 47 | +14 | Waltz with Bashir | $54,400 | $53,564 | -$836 | -1.5% | 5 | $160,000 | $220,441 | 2 | Sony Pictures Classics | - |
| 34 | 51 | +17 | Synecdoche, New York | $52,000 | $44,825 | -$7,175 | -13.8% | 39 | $2,713,000 | $2,705,849 | 11 | Sony Pictures Classics | - |
| 35 | 54 | +19 | Vicky Cristina Barcelona | $44,000 | $40,424 | -$3,576 | -8.1% | 25 | $22,835,000 | $22,830,692 | 21 | Metro-Goldwyn-Mayer (MGM) | - |
| 36 | 56 | +20 | Che: Part One/Che: Part Two | $35,600 | $35,484 | -$116 | -0.3% | 2 | $215,000 | $218,470 | 4 | IFC Films | - |
| 37 | 58 | +21 | Wendy and Lucy | $26,800 | $24,938 | -$1,862 | -6.9% | 4 | $112,000 | $111,329 | 4 | Oscilloscope | - |
