| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Bedtime Stories | $2,421,651 | - | 600 | - | $4,036 | $3,264,574 | 1 | Walt Disney Pictures | true | false |
| 2 | 2 | Rudo y Cursi | $1,027,074 | -24.2% | 423 | +16 | $2,428 | $5,997,610 | 3 | Universal Pictures International (UPI) | false | false |
| 3 | 1 | Bolt | $881,852 | -43.4% | 633 | -67 | $1,393 | $6,169,422 | 3 | Walt Disney Pictures | false | false |
| 4 | 5 | Australia | $751,965 | -20.4% | 393 | +24 | $1,913 | $2,690,432 | 2 | 20th Century Fox International | false | false |
| 5 | 3 | Madagascar: Escape 2 Africa | $662,006 | -42% | 426 | -8 | $1,554 | $15,575,472 | 5 | Paramount Pictures International | false | false |
| 6 | 4 | The Day the Earth Stood Still | $555,001 | -43.4% | 400 | -21 | $1,387 | $8,605,788 | 4 | 20th Century Fox International | false | false |
| 7 | 7 | Volverte a ver | $422,221 | +7.6% | 337 | +3 | $1,252 | $1,301,972 | 2 | Videocine | false | false |
| 8 | 6 | The Tale of Despereaux | $403,949 | -44.2% | 414 | -126 | $975 | $1,838,878 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | 8 | Four Christmases | $259,720 | -31.8% | 288 | +3 | $901 | $1,597,526 | 3 | Gussi Films | false | false |
| 10 | 9 | Twilight | $182,258 | -22.8% | 169 | -19 | $1,078 | $9,565,133 | 7 | Corazón Films | false | false |
| 11 | 11 | The Boy in the Striped Pajamas | $43,937 | +35.1% | 24 | +2 | $1,830 | $464,701 | 6 | Walt Disney Pictures | false | false |
| 12 | 12 | Vicky Cristina Barcelona | $34,223 | +17.2% | 22 | -1 | $1,555 | $695,359 | 5 | Gussi Films | false | false |
| 13 | 10 | Free Style | $30,018 | -64.2% | 180 | -18 | $166 | $194,534 | 2 | 20th Century Fox International | false | false |
| 14 | 13 | Saw V | $17,419 | -35.5% | 23 | -13 | $757 | $994,554 | 10 | Walt Disney Pictures | false | false |
| 15 | 15 | The Duchess | $16,713 | +6.5% | 12 | -1 | $1,392 | $328,560 | 7 | Paramount Pictures International | false | false |
| 16 | 14 | Body of Lies | $8,083 | -50.9% | 18 | -6 | $449 | $2,101,065 | 6 | Warner Bros. | false | false |
| 17 | 19 | Frozen River | $5,954 | +56.4% | 3 | - | $1,984 | $50,080 | 9 | Sony Pictures Releasing | false | false |
| 18 | 17 | Solstice | $5,499 | -42% | 10 | -4 | $549 | $415,633 | 5 | Videocine | false | false |
| 19 | 16 | Disaster Movie | $3,337 | -75.5% | 8 | -11 | $417 | $584,125 | 6 | Gussi Films | false | false |
| 20 | 20 | Nick and Norah's Infinite Playlist | $1,845 | -30.4% | 3 | - | $615 | $97,366 | 5 | Sony Pictures Releasing | false | false |
| 21 | 23 | Quantum of Solace | $922 | -2.2% | 8 | -1 | $115 | $5,979,855 | 8 | Sony Pictures Releasing | false | false |
| 22 | 21 | X-mas, Inc. | $877 | -49.9% | 8 | -8 | $109 | $3,584,671 | 8 | Warner Bros. | false | false |
| 23 | 18 | Lakeview Terrace | $824 | -85.7% | 3 | -5 | $274 | $120,097 | 7 | Sony Pictures Releasing | false | false |
| 24 | 25 | The House Bunny | $318 | -53.1% | 3 | - | $106 | $1,333,183 | 11 | Sony Pictures Releasing | false | false |
| 25 | 31 | Pineapple Express | $202 | +29.5% | 1 | - | $202 | $143,440 | 13 | Sony Pictures Releasing | false | false |
| 26 | 29 | Impy's Island | $138 | -23.8% | 1 | -5 | $138 | $264,092 | 8 | Gussi Films | false | false |
